A5024184287- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Coronary Interventions and Diagnostics
- Cardiovascular Function and Risk Factors
- Aortic Disease and Treatment Approaches
- Cardiac Arrhythmias and Treatments
- Cardiomyopathy and Myosin Studies
- Cardiac Imaging and Diagnostics
- Cardiovascular and Diving-Related Complications
- Atrial Fibrillation Management and Outcomes
- Intracranial Aneurysms: Treatment and Complications
- Cardiac Structural Anomalies and Repair
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac pacing and defibrillation studies
- Acute Myocardial Infarction Research
- Coronary Artery Anomalies
- Traumatic Brain Injury and Neurovascular Disturbances
- Congenital Heart Disease Studies
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Effects of Exercise
- Cardiac and Coronary Surgery Techniques
- Kawasaki Disease and Coronary Complications
- Traumatic Ocular and Foreign Body Injuries
- Mechanical Circulatory Support Devices
- Heart Failure Treatment and Management
CTO Andrea Alesini
2024-2025
IRCCS Policlinico San Donato
2018-2024
Azienda Ospedaliera Sant'Andrea
2017-2024
Sapienza University of Rome
2014-2023
Molecular Medicine Ireland
2015
European Hospital
2014
Columbia University
2013
The ACURATE neo2 (NEO2) and Evolut PRO/PRO+ (PRO) bioprostheses are new-generation self-expanding valves developed for transcatheter aortic valve replacement (TAVR).
A substantial number of patients with severe aortic stenosis (AS) undergoing transcatheter valve implantation (TAVI) experience adverse events after TAVI, health care expenditure. We aimed to investigate cardiac remodeling and long-term outcomes in diabetic AS, left ventricular ejection fraction (LVEF) < 50%, extra-valvular damage (EVCD) TAVI treated sodium-glucose cotransporter-2 inhibitors (SGLT2i) versus other glucose-lowering strategies (no-SGLT2i users). Multicenter international...
<h3>Background</h3> In hypertrophic cardiomyopathy (HCM), most of the factors associated with risk sudden cardiac death (SCD) are also involved in pathophysiology exercise limitation. The present multicentre study investigated possible ability cardiopulmonary test improving contemporary strategies for SCD stratification. <h3>Methods</h3> A total 623 consecutive outpatients HCM, from five tertiary Italian HCM centres, were recruited and prospectively followed, between September 2007 April...
Background:Heart failure (HF) progression and its complications represent major emergent concerns in hypertrophic cardiomyopathy (HCM). We investigated the possible adjunctive role of cardiopulmonary exercise testing (CPET) predicting HF-related events. An exercise-derived risk model, theHYPertrophicExercise-derivedRiskHF(HYPERHF), has been developed.
Transcatheter aortic valve replacement (TAVR) with the ACURATE neo device has been associated a non-negligible incidence of paravalvular regurgitation (AR). The new-generation neo2 designed to mitigate this limitation.The aim study was compare TAVR and devices.The NEOPRO NEOPRO-2 registries retrospectively included patients undergoing transfemoral self-expanding valves at 24 20 centres, respectively. Patients receiving devices (from January 2012 December 2021) were in study. Predischarge...
Interventional cardiologists have recently become increasingly entrusted with the treatment of frail patients complex coronary anatomy. Additionally, calcified lesions (CLs) more common due to continued increase in older population worldwide, increasing need for simpler options such lesions. Hence, numerous debulking tools been developed overcome difficulties associated angioplasty CLs and optimize stent positioning delivery. In addition, bifurcation (BLs) always challenging than other...
Oxygen uptake at the anaerobic threshold (VO2AT), a submaximal exercise-derived variable, independent of patients' motivation, is marker outcome in heart failure (HF). However, previous evidence VO2AT values paradoxically higher HF patients with permanent atrial fibrillation (AF) than those sinus rhythm (SR) raised uncertainties. We tested prognostic role large cohort systolic patients, focusing on possible differences between SR and AF. Altogether 2976 (2578 398 AF) were prospectively...
Abstract Objectives To investigate paravalvular leak (PVL) and devices success rates according to aortic angle (AA) in patients undergoing transcatheter valve implantation (TAVI) with three new‐generation self‐expanding devices. Background The impact of on TAVI device PVL is controversial. Methods This retrospective study included 392 submitted for severe stenosis Portico, Evolut‐R Acurate‐NEO, available AA measurements at computed tomography (CT) angiography. was calculated from the...
Abstract Background The recently introduced intravascular lithotripsy (IVL) appears promising and relatively safer than conventional approaches when dealing with calcified lesions. Although there are published reports on this novel technology, data from the real world limited. In study, we aim to report experience of IVL a real‐world population derived six European centers that undertake high‐volume complex coronary interventions. Methods results We enrolled all patients treated between...
To evaluate the prognostic impact of baseline tricuspid annular plane systolic excursion/pulmonary artery pressure (TAPSE/PASP) ratio, as an expression right ventricle-pulmonary (RV-PA) coupling, in patients with mitral regurgitation (MR) treated MitraClip.Impaired RV to PA coupling is considered a marker dysfunction.From February 2016 2020, total 165 were evaluated and stratified two groups according prespecified value TAPSE/PASP ratio ≤ 0.36.The median patients' age was 79 (men: 62.4%)....
Background: Transcatheter aortic valve replacement (TAVR) has determined a paradigm shift in the treatment of patients with severe stenosis. However, durability bioprostheses is still matter concern, and little known about management degenerated TAV. We sought to evaluate outcomes TAV treated by means second TAVR. Methods: The TRANSIT an international registry that included cases TAVR from 28 centers. Among around 40 000 participating centers, 172 underwent TAVR: 57 (33%) for mainly stenotic...
In the context of primary mitral regurgitation (PMR), selection patients for transcatheter edge-to-edge repair (TEER) does not include a systematic assessment PMR-associated cardiac remodelling.We aimed to investigate epidemiology and prognostic significance different phenotypes extra-mitral valve (MV) involvement in large series with PMR referred TEER.The study included 654 from multicentre Italian GIOTTO registry, stratified into groups according involvement. The endpoint was all-cause...
Abstract OBJECTIVES To compare device success and paravalvular leak rates of 3 new-generation transcatheter aortic valve replacement devices in patients with bicuspid stenosis to test their biomechanical performance a computer-based simulation model root increasing ellipticity. METHODS This retrospective multicentre study included 56 undergoing devices: Lotus/Lotus Edge (N = 15; 27%), Evolut-R 20; 36%) ACURATE neo 21; 37%). Three virtual models index eccentricity (0–0.25–0.5) were...