A5014041155- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging and Pathology Studies
- Lymphoma Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Cutaneous Melanoma Detection and Management
- Cancer, Hypoxia, and Metabolism
- Neuroblastoma Research and Treatments
- Genomics and Chromatin Dynamics
- Monoclonal and Polyclonal Antibodies Research
- CAR-T cell therapy research
- Hematological disorders and diagnostics
- CNS Lymphoma Diagnosis and Treatment
- RNA Research and Splicing
- Adrenal and Paraganglionic Tumors
- Immune Cell Function and Interaction
- Viral Infectious Diseases and Gene Expression in Insects
- Hepatitis B Virus Studies
- NF-κB Signaling Pathways
- Lung Cancer Diagnosis and Treatment
- Cutaneous lymphoproliferative disorders research
- Advanced Radiotherapy Techniques
- Advanced X-ray and CT Imaging
- Digital Radiography and Breast Imaging
Friedrich-Alexander-Universität Erlangen-Nürnberg
2016-2022
Universitätsklinikum Erlangen
2016
University Hospital Bonn
2004-2012
Klinik und Poliklinik für Nuklearmedizin
2004-2006
University of Bonn
2002-2004
Hospital of the University of Pennsylvania
2000-2002
University of Pennsylvania
2000
University of Göttingen
1994
St George's, University of London
1992
To assess the diagnostic performance of positron emission tomography/computed tomography (PET/CT) using (18)F-fluorodeoxyglucose (FDG) for N- and M-staging cutaneous melanoma.This is a retrospective blinded study 250 consecutive patients (105 women, 145 men; age 58 +/- 16 years) who underwent FDG-PET/CT staging melanoma at different time points in course disease. Whole-body was performed 101 21 minutes postinjection 371 41 MBq FDG. Diagnostic accuracy determined CT alone, PET PET/CT.PET/CT...
Due to the critical impact of active AP-1 transcription factors in melanoma, it is important define their target genes and identify ultimately inhibit oncogenic signals. Here we mapped genome-wide occupancy family member c-Jun different melanoma cells correlated binding with transcriptome data detect regulated by c-Jun. Our analysis shows that supports malignant phenotype deregulating cancer-relevant signaling pathways, such as mitogen-activated protein kinase (MAPK)...
Abstract The effect of glucose stimulation (25 mM for 5 min) on the phospholipid and neutral lipid composition isolated pancreatic islets was studied to find out whether there is a change in mass potential mediators or modulators insulin secretion. For comparison, compositions homogenates subcellular fractions from RINm5F insulin‐secreting tumor cells glucose‐stimulated streptozotocin/nicotinamide‐induced islet cell tumors were analyzed. After separation extract into an acidic fraction by...
Modifications in nuclear structures of cells are implicated several diseases including cancer. They result changes activity, structural dynamics and cell signalling. However, the role lamina related proteins malignant melanoma is still unknown. Its molecular characterisation might lead to a deeper understanding development new therapy approaches. In this study, we analysed functional effects dysregulated lamin B1 (LMNB1) its receptor (LBR). According their cellular localisation function,...
The neural crest transcription factor BRN3A is essential for the proliferation and survival of melanoma cells. It frequently expressed in but not normal melanocytes or benign nevi. mechanisms underlying aberrant expression are unknown. Here, we investigated epigenetic regulation cell lines treated with DNA methyltransferase (DNMT), histone acetyltransferase (HAT), deacetylase (HDAC) inhibitors. DNMT HAT inhibition did significantly alter levels, whereas panHDAC by trichostatin A led to...
Abstract Dendritic cells (DCs) are considered to be the major APCs with potent activity for priming of naive CD4 and CD8 T cells. However, cell can also achieved by other including macrophages, B cells, or even nonhematopoietic types. Systemic low-dose infection mice lymphocytic choriomeningitis virus (LCMV) results in massive expansion virus-specific To determine role DCs as source type I IFNs this model, we used ΔDC which constitutively ablated because expression diphtheria toxin α subunit...
Alginate hydrogels have been used as a biomaterial for 3D culturing several years. Here, gene expression patterns in melanoma cells cultivated alginate are compared to 2D cultures. It is well-known that cell culture not resembling the complex vivo situation well. However, use of very intricate models does allow performing high-throughput screening and analysis highly complex. strategies will better mimic while they maintain feasibility large-scale analysis. As an easy-to-use material due its...
Percutaneous Ethanol Ablation of an Adrenal TumorDaniel D. Maki1, Ziv J. Haskal1 2, Alexander Matthies1, Jill Langer1, Harvey L. Nisenbaum1, David Vaughn3 and Abass Alavi1Audio Available | Share
Abstract The pathogenesis of Hodgkin's disease (HD) is associated with the accumulation functionally anergic T cells in near vicinity malignant Hodgkin/Reed‐Sternberg (H/RS) cell. To stimulate locally anti‐tumour immunity disease, we generated an anti‐CD30‐antibody‐interleukin‐2 fusion protein (HRS3‐scFv‐Fc‐IL‐2) that binds to CD30 constitutively expressed on H/RS cells. composed a binding domain (HRS3‐scFv) linked via human IgG hinge‐CH2/CH3 IL‐2. HRS3‐scFv‐Fc‐IL‐2 as 140 kDa homodimer, has...
Es liegen zunehmend Belege dafür vor, dass das 18FDG-PET für die Bildgebung des primären Prostatakarzinoms nicht geeignet ist. Ziel der vorliegenden Untersuchung war es, zu überprüfen, ob diesen schlechten Ergebnissen technische Unzulänglichkeiten Untersuchungsmethode Grunde liegen, wie veralterte Bildrekonstruktionstechniken, Akkumulation Radiotracers in Harnblase oder ungeeignete Kontrastdarstellung Rektums. Wir untersuchten drei Patienten mit primärem Prostatakarzinom unter Verwendung...
131I-MIBG therapy for neuroendocrine tumours may be dose limited. The common range of applied cumulative activities is 10-40 GBq. We report the uneventful administration 111 GBq (= 3 Ci) in a patient with metastatic paraganglioma. Ten courses were given within six years, accomplishing symptomatic, hormonal and tumour responses no serious adverse effects. Chemotherapy cisplatin/vinblastine/dacarbazine was final treatment modality temporary control disease, but eventually died progression....
In malignant melanoma, a highly aggressive form of skin cancer, many microRNAs are aberrantly expressed contributing to tumorigenesis and progression. Further, deregulation microRNA processing enzymes, like the miRNA-binding protein Argonaute 2, significantly impacts function. This study characterizes novel splice variant Argonaut AGO2-ex1/3. AGO2-ex1/3 is substantially in different melanoma cell lines patient-derived tissue samples. It mature mRNA, which translated into an N-terminally...
The prognosis of patients with progressive intermediate-grade non-Hodgkin's lymphoma (NHL) after high-dose chemotherapy and autologous peripheral stem-cell transplantation (PSCT) is poor, survival measured in months. advent monoclonal antibody therapy for NHL has created new options effective relatively mild side effects. We report on two PSCT who were treated therapy. Both initially received rituximab (unlabeled anti-CD20 antibody) subsequently 90Y-epratuzumab (yttrium-90—labeled humanized...