A5003826023- Lipoproteins and Cardiovascular Health
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Cancer, Lipids, and Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Immune cells in cancer
- Hormonal Regulation and Hypertension
- Chromosomal and Genetic Variations
- Ion Transport and Channel Regulation
- Antioxidant Activity and Oxidative Stress
- Liver Disease and Transplantation
- Pancreatic and Hepatic Oncology Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Plant Virus Research Studies
- COVID-19 Clinical Research Studies
- Electrolyte and hormonal disorders
- Cerebrovascular and Carotid Artery Diseases
- Liver Diseases and Immunity
- Neuropeptides and Animal Physiology
- Eicosanoids and Hypertension Pharmacology
- Vitamin K Research Studies
- Inhalation and Respiratory Drug Delivery
Medical University of Silesia
2015-2025
University of Silesia in Katowice
2023
Górnośląskie Centrum Medyczne
2021
Abstract The aim of this study was to assess the influence cisplatin and an extremely low frequency electromagnetic field (ELF‐EMF) on antioxidant enzyme activity lipid peroxidation ratio, as well level DNA damage reactive oxygen species (ROS) production in AT478 carcinoma cells. Cells were cultured for 24 72 h culture medium with cisplatin. Additionally, cells irradiated 50 Hz/1 mT ELF‐EMF 16 min using a solenoid source ELF‐EMF. amount ROS, superoxide dismutase (SOD) isoenzyme activity,...
Obesity is associated with an increased risk of certain types cancer, including colon cancer. Adipose tissue endocrine organ that produces biologically active substances, such as leptin and ghrelin. Recent research has suggested adipose-derived hormones may be mechanisms linked to tumorigenesis cancer progression. Furthermore, previous studies have demonstrated pineal gland-derived melatonin possesses important oncostatic antioxidant properties. The present study aimed determine the effects...
Cholangitis and biliary sepsis are severe infectious diseases, which often observed in patients with choledocholithiasis. The antimicrobial therapy is effective if started as soon the diagnosis made. Therefore, profile of bile pathogens its susceptibility to a number antibiotics were evaluated.Bile cultures antibiograms from 92 hospitalized between January 2006 December 2008 tertiary referral center for treatment pancreatic diseases (Central Teaching Hospital, Medical University Silesia)...
Macrophages are dominant cells in the pathogenesis of atherosclerosis. They also a major source reactive oxygen species (ROS). Oxidative stress, which is particularly high subjects with diabetes, responsible for accelerated Novel antidiabetic drugs (e.g., glucagon-like peptide-1 (GLP-1) agonists) were shown to reduce ROS level. Therefore, we conceived study evaluate influence exenatide, GLP-1 agonist, on redox status human monocytes/macrophages cultured vitro, may explain beneficial effects...
Monocytes are key elements in pathogenesis of atherosclerosis and inflammation. The data regarding associations between antihypertensive treatment monocytes' function still lacking. aim this study was to evaluate the influence drugs (bisoprolol, perindopril or both) patients suffering from mild moderate hypertension.The population consisted 67 divided into 3 groups (2 with Grade I essential hypertension one II hypertension). At baseline 1 month after we performed 24-h ambulatory noninvasive...
Concerns regarding worsening insulin sensitivity associated with statin treatment have recently emerged. Therefore the aim of this study was to assess and compare effects 90-day monotherapies fenofibrate atorvastatin, as well combined therapy, on fasting plasma glucose, resistance index, adipokines (leptin, resistin, adiponectin) levels proinflammatory cytokines (TNF-α, IL-6) in patients impaired glucose (IFG) mixed hyperlipidemia.67 were randomly assigned four arms: monotherapy fenofibrate,...
Proprotein convertase subtilisin/kexin 9 (PCSK9) is a protein that plays key role in the metabolism of low-density lipoprotein (LDL) cholesterol. The gain-of-function mutations PCSK9 gene lead to reduced number surface LDL receptors by binding them, eventually leading endosomal degradation. This, turn, culprit hypercholesterolemia, resulting accelerated atherogenesis. modern treatment for hypercholesterolemia encompasses use biological drugs against PCSK9, like monoclonal antibodies and...