A5001406717- Hematopoietic Stem Cell Transplantation
- Multiple Myeloma Research and Treatments
- Cancer Treatment and Pharmacology
- Acute Myeloid Leukemia Research
- T-cell and B-cell Immunology
- Chronic Myeloid Leukemia Treatments
- Neutropenia and Cancer Infections
- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- Protein Degradation and Inhibitors
- COVID-19 Clinical Research Studies
- Immunotherapy and Immune Responses
- Single-cell and spatial transcriptomics
- Mesenchymal stem cell research
- Gene expression and cancer classification
- HIV/AIDS drug development and treatment
- Gene Regulatory Network Analysis
- Genetic and Kidney Cyst Diseases
- Hematological disorders and diagnostics
- Blood disorders and treatments
- Breast Cancer Treatment Studies
- Acute Lymphoblastic Leukemia research
- Long-Term Effects of COVID-19
- Genetic Syndromes and Imprinting
Ospedale Vincenzo Cervello
2025
Ceinge Biotecnologie Avanzate (Italy)
2020-2024
ASL Roma
2021
Azienda ospedaliera "Bianchi-Melacrino-Morelli"
2009-2017
Istituto di Fisiologia Clinica
2015
Weatherford College
2012-2013
University of Reggio Calabria
2009-2012
National Cancer Institute
2006
University of Messina
2001-2003
Abstract In recent months, Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread throughout the world. COVID-19 patients show mild, moderate or symptoms with latter ones requiring access to specialized intensive care. SARS-CoV-2 infections, pathogenesis and progression have not been clearly elucidated yet, thus forcing development of many complementary approaches identify candidate cellular pathways involved in progression. Host...
COVID-19 is a global threat that has spread since the end of 2019, causing severe clinical sequelae and deaths, in context world pandemic. The infection highly pathogenetic infectious SARS-CoV-2 coronavirus been proven to exert systemic effects impacting metabolism. Yet, metabolic pathways involved pathophysiology progression are still unclear. Here, we present results mass spectrometry-based targeted metabolomic analysis on cohort 52 hospitalized patients, classified according disease...
Methylmalonic acidemia (MMA) is a rare inborn error of metabolism caused by deficiency the methylmalonyl-CoA mutase (MUT) enzyme. Downstream MUT deficiency, methylmalonic acid accumulates together with toxic metabolites from propionyl-CoA and other compounds upstream block in enzyme pathway. The presentation life-threatening acidosis, respiratory distress, brain disturbance, hyperammonemia, ketosis. Survivors develop poorly understood multi-organ damage, notably to kidneys. HEK 293 cell line...
Mucopolysaccharidoses (MPSs) are inherited disorders of the glycosaminoglycan (GAG) metabolism. The defective digestion GAGs within intralysosomal compartment affected patients leads to a broad spectrum clinical manifestations ranging from cardiovascular disease neurological impairment. molecular mechanisms underlying progression downstream genetic mutation genes encoding for lysosomal enzymes still remain unclear. Here, we applied targeted metabolomic approach mouse model PS IIIB, using...
ABSTRACT HLA‐C*04:533 differs from C*04:01:01:14 by a single non‐synonymous nucleotide change in codon 216 (ACC>AAC).
ABSTRACT HLA‐C*02:231 differs from C*02:02:02:79 by a single non‐synonymous nucleotide change in codon 124 (ATC>GTC).
Different factors influence the clinical outcome of allogeneic transplants, foremost being good immune recovery.The purpose this study was to evaluate different factors, such as stem cell source, type donor, conditioning regimen and acute graft-versus-host disease, on early lymphocyte recovery after transplantation. We then analyzed impact CD4+ count overall survival, transplant-related mortality disease-related mortality.Univariate analysis with Spearman's rho showed a significant...
Cystic fibrosis is a hereditary metabolic disorder characterized by impaired traffic of chloride ions and water through membranes the respiratory gastrointestinal, that causes inadequate hydration airway surfaces, dehydrated mucous secretions high-sodium sweat. Although classical presentation condition well known, better characterization alterations related need. In particular, composition biological fluids may be influence disease state could captured as putative signature to set targeted...
Background Peripheral blood ( PB ) hematopoietic progenitor cells HPC collected by apheresis are the first‐choice source for allogeneic stem cell transplantation. The target dose is usually considered to be 4 × 10 6 CD 34+ cells/kg of recipient, but higher doses required in reduced‐intensity conditioning and haploidentical transplants. Thus, prolonged stimulation repeated collections or failure reach may occur, increasing risks donors recipients. We carried out a retrospective multicenter...
Methylmalonic acidemia is a rare inborn error of metabolism with severe clinical complications and poor outcome. The present data article related to proteomic investigation conducted on HEK 293 cell line which has been genetically modified using CRISPR-CAS9 system knockout the methylmalonyl-CoA mutase enzyme (MUT-KO). Thus, generated model for methylmalonic was used comparison respect wild type cells performing label-free quantification (LFQ) experiment. A between FASP S-Trap digestion...
Patients with chronic myeloid leukemia relapsing after allogeneic hematopoietic stem cell transplantation may be treated by tyrosine kinase inhibitors and/or donor lymphocyte infusions. The best strategies and timing of administration lymphocytes are unclear. We analyzed 155 patients who relapsed disease detectable only molecular methods subsequently received lymphocytes. Transplants were performed in first phase (n=125) or advanced (n=29) from identical siblings (n=84) unrelated donors...
We reviewed and analyzed safety efficacy data after mobilization with granulocyte colony-stimulating factor (G-CSF) according to healthy donor's (HDs) age as follows: <50 years (HDs-1, n = 161), aged 50 59 (HDs-2, 62), ≥60 or over (HDs-3, 23). Two hundred forty-six HDs were evaluated, their characteristics well balanced among groups: most male, siblings, HLA matched. According group, the median numbers of CD34(+) cells in peripheral blood for HDs-1, HDs-2, HDs-3 were, respectively, 44.5,...
Bardet-Biedl syndrome (BBS) is a rare autosomal recessive ciliopathy resulting in multiple organ dysfunctions, including chronic kidney disease (CKD). Despite the recent progress 'ciliopathy' field, there still little information on mechanisms underlying renal disease. To elucidate these pathomechanisms, we conducted translational study, (i) characterization of urine metabolomic pattern BBS patients and controls pilot confirmation study (ii) proteomic analysis BBS10 interactome, one major...
Chronic kidney disease (CKD) is a major clinical sign of patients with Bardet-Biedl syndrome (BBS), especially in those carrying BBS10 mutations. Twenty-nine BBS and 30 controls underwent serum-targeted metabolomic analysis. In vitro studies were conducted two kidney-derived epithelial cell lines, where Bbs10 was stably deleted (IMCD3-Bbs10-/-cells) over-expressed. The CKD status affected plasmatic metabolite fingerprinting both controls. Specific phosphatidylcholine acylcarnitines...