A5046626030- Mosquito-borne diseases and control
- Parasites and Host Interactions
- Travel-related health issues
- Malaria Research and Control
- Global Maternal and Child Health
- Parasite Biology and Host Interactions
- COVID-19 epidemiological studies
- Stroke Rehabilitation and Recovery
- Research on Leishmaniasis Studies
- Viral Infections and Vectors
- Palliative Care and End-of-Life Issues
- Hepatitis Viruses Studies and Epidemiology
- Cerebral Palsy and Movement Disorders
- Trypanosoma species research and implications
- Clinical practice guidelines implementation
- Sinusitis and nasal conditions
- Acute Ischemic Stroke Management
- Parasitic infections in humans and animals
- Viral gastroenteritis research and epidemiology
- Parasitic Diseases Research and Treatment
- HIV/AIDS Research and Interventions
- Balance, Gait, and Falls Prevention
- Amoebic Infections and Treatments
- Childhood Cancer Survivors' Quality of Life
- Historical and Architectural Studies
Film Independent
2024
University of Alabama at Birmingham
2022-2024
Hospital for Tropical Diseases
2009-2022
University College London Hospitals NHS Foundation Trust
2017-2022
University College London
2004-2022
Northern Sydney Local Health District
2002-2021
Mortimer Market Centre
2003-2019
University College Hospital
2018-2019
Fundação Getulio Vargas
2016-2018
University of New Mexico
2018
Background. Diagnosis of malaria relies on parasite detection by microscopy or antigen detection; both fail to detect low-density infections. New tests providing rapid, sensitive diagnosis with minimal need for training would enhance and control activities. We determined the diagnostic accuracy a new loop-mediated amplification (LAMP) kit in febrile returned travelers.
Schistosomiasis is found in a significant proportion of returning travellers and immigrants to Britain. This study retrospective review 1107 consecutive cases schistosomiasis from Africa diagnosed by microscopy or serology presenting the Hospital for Tropical Diseases, London, UK. 50.4% were asymptomatic. The most common symptom which resolved on treatment was tiredness. Serology positive 951 (86%), ova seen 45%. Urine dipstick testing blood 21% protein 15%, with eosinophilia 44%. In this...
Summary Objectives To assess whether the clinical and laboratory methods for diagnosing Strongyloides stercoralis infection in non‐endemic countries is different between those who are chronically exposed travel. Methods Analysis of data from 204 patients having S. at Hospital Tropical Diseases, London. Results Sixty‐four travellers 128 immigrants endemic had laboratory‐proven strongyloides. In with microscopically proven disease, serology was 73% sensitive 98% ( P < 0.001). There no...
Abstract Background Malaria is the commonest imported infection in UK. requiring ICU admission has a reported mortality of up to 25%. The relationship between ethnicity, immunity, and risk malaria complex. Score for Adults (MSA) Coma Acidosis (CAM) score have recently been proposed stratify patients with malaria. Methods Retrospective study WHO severe falciparum admitted at Hospital Tropical Diseases, London, clinical variables death or prolonged stay were examined logistic regression....
Our current knowledge of the clinical characteristics enteric fever is drawn mainly from population-based studies in disease-endemic countries, and there are limited data published on cases returning travelers. We report 92 travelers to London, United Kingdom. Salmonella typhi S. paratyphi resulted an almost indistinguishable picture. Rose spots relative bradycardia were found only a few patients. A total 91% patients had normal leukocyte count, which was associated with markedly increased...
This study reviewed all patients diagnosed with imported cutaneous leishmaniasis (CL) at the Hospital for Tropical Diseases in London, United Kingdom, over an 11-year period. Diagnostic and epidemiologic information was collected prospectively CL to this hospital during 1998–2009. A total of 223 were given a diagnosis CL. Ninety Old World CL, which caused most commonly by Leishmania donovani complex (n = 20). 71% tourists Mediterranean region, 36% migrants or visiting friends relatives, 17%...
All of the pathologic and bacteriologic work mentioned herein was done by Doctor Armstrong, pathologist for head specialties in University Hospital.. The importance sinusitis infants young children is always made plain to us reviewing some our cases.We think first case that responsible this subject.It a boy eight years age who had multiple arthritis; he confined bed; could not feed himself.In January, 1917, I removed his tonsils adenoids examined nasal sinuses, reported no condition...
Summary objectives To examine the utility of different elements screening expatriates and travellers returned from tropics for parasitic disease (exposure history, symptoms, examination laboratory tests). methods In phase 1 (conducted prospectively 1990–91), 1029 asymptomatic returnees had a detailed questionnaire interview on risk‐behaviour, physical tests. 2 (1997–98), 510 consecutive patients referred routine (276 symptomatic 234 asymptomatic) were screened with results Exposure history...
Use of parenteral pentavalent antimonials to treat leishmaniasis is associated with a range cardiological, biochemical and haematological adverse effects. The most serious these the development ventricular tachyarrhythmias prolongation electrocardiographic rate-corrected QT interval (QTc). Whereas some studies have reported that cardiological effects are common often require treatment interruption or discontinuation, others drugs be well tolerated. We conducted detailed retrospective...
We sought to identify chloroquine-resistant Plasmodium falciparum parasites among 66 travellers who presented in the UK with malaria. A multiplex real-time PCR assay was devised wild-type and two distinct chloroquine-resistance-associated alleles of pfcrt gene. Those documented use chloroquine/proguanil prophylaxis were more likely carry resistance-associated than patients had been using antimalarials other chloroquine (92.9% versus 37.5%; P = 0.011). also found evidence that people...
Patients with New World cutaneous leishmaniasis (NWCL) caused by Leishmania Viannia are treated parenteral sodium stibogluconate (SbV) to reduce the risk of development mucocutanous leishmaniasis. Our centre manages patients NWCL on an outpatient-basis. This study was conducted assess safety and efficacy this approach.We reviewed records 67 consecutive patients, aged 17-61 years, as day-cases 20 mg/kg/day SbV for up 28 days at our UK centre. Data had been collected in a standardised format...
Kits for self-diagnosis of malaria by travelers in remote areas have been advocated. Antigen-capture test cards work reliably the laboratory, but there is limited data regarding self-testing ill patients. One hundred and fifty-three symptomatic patients presenting a attempted using these kits. Nine percent failed to perform valid test. Against blood-film proven malaria, specificity was 97% (95% confidence intervals [CI] 93-99%) sensitivity 95% CI 74-99%). Although results are encouraging,...
Malaria is currently diagnosed almost exclusively by microscopy in clinical laboratories. The introduction of rapid diagnostic tests (RDTs) may be useful achieving detection malaria parasites, especially situations where not often seen or staff are inexperienced.To explore the use RDT UK laboratories.The current RDTs was surveyed laboratories subscribing to United Kingdom National External Quality Assessment Scheme blood parasitology and haematology schemes.An overall survey response rate...
This study describes the clinical features of a cohort imported cases strongyloidiasis and performance standard diagnostic techniques for this condition. A total 413 were identified, whom 86 had microscopically proven infection. In cases, 23% normal eosinophil counts, 19% negative Strongyloides -specific serology, 9.3% blood counts seronegative. Serological testing was less sensitive returning travelers (46.2%) than migrants (89.7%). Immunosuppression, including human T-cell lymphotropic...
We report 79 cases of acute schistosomiasis. Most these were young, male travelers who acquired their infection in Lake Malawi. Twelve had a normal eosinophil count at presentation and 11 negative serology, although two neither eosinophilia nor positive serology when first seen. Acute schistosomiasis should be considered any febrile traveler with history fresh water exposure an endemic area once malaria has been excluded.
We retrospectively analyzed the background, clinical features, and treatment response of 50 cases imported loiasis who presented between 2000 2014 to Hospital for Tropical Diseases (HTD), London, United Kingdom. Of them, 29 were migrants from, 21 visitors to, countries where disease is endemic. Clinical features differed these groups. Migrants experienced fewer Calabar swellings (odds ratio [OR] = 0.12), more eye worm (OR 3.4), microfilaremia 3.5), lower filarial antibody levels, eosinophil...
Background Leprosy is rare in the United Kingdom (UK), but migration from endemic countries results new cases being diagnosed each year. We documented clinical presentation of leprosy a non-endemic setting. Methods Demographic and data on all managed Clinic at Hospital for Tropical Diseases, London between 1995 2018 were analysed. Results 157 individuals with median age 34 (range 13–85) years included. 67.5% male. Patients came different most contracted before migrating to UK. Eighty-two...