A5059683638- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Dementia and Cognitive Impairment Research
- Prostate Cancer Treatment and Research
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Renal cell carcinoma treatment
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Chemokine receptors and signaling
- Frailty in Older Adults
- Renal and related cancers
- Peptidase Inhibition and Analysis
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Nutrition and Health in Aging
- HER2/EGFR in Cancer Research
- Lung Cancer Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Cell Adhesion Molecules Research
- Cancer Genomics and Diagnostics
- Occupational and environmental lung diseases
- Sexual function and dysfunction studies
- Radioactive Decay and Measurement Techniques
- S100 Proteins and Annexins
Ospedale di Parma
2013-2024
University of Parma
2012-2024
Regione Lazio
2023
Agenzia Regionale Parchi
2023
Christie's
2023
Radboud University Nijmegen
2021
Radboud University Medical Center
2021
Justus-Liebig-Universität Gießen
2021
Ospedale Maggiore
2007
In January 2020, the coronavirus disease 2019 (COVID-19) outbreak in Italy necessitated rigorous application of more restrictive safety procedures management and treatment patients with cancer to ensure patient staff protection. Identification respiratory syndrome 2 (SARS-CoV-2) infection was a challenge during pandemic owing large number asymptomatic or mildly symptomatic patients.We report 5 unknown SARS-CoV-2 undergoing positron emission tomography (PET)/computed (CT) radiopharmaceuticals...
Glucagon-like peptide 1 receptor (GLP-1R) is preferentially expressed in pancreatic islets, especially β-cells, and highly human insulinomas gastrinomas. In recent years several GLP-1R-avid radioligands have been developed to image insulin-secreting tumors or provide a tentative quantitative vivo biomarker of β-cell mass. Exendin-4, 39-amino acid with high binding affinity GLP-1R, has labeled Ga-68 for imaging positron emission tomography (PET). Preparation conditions may influence the...
Background: Prostate-specific membrane antigen (PSMA) has gained high attention as a useful biomarker in the imaging evaluation of prostate cancer with positron emission tomography (PET) during recent years. [68Ga]-labeled Glu-urea-Lys(Ahx)-HBED-CC ([68Ga]-PSMA-HBED-CC) is novel PSMA inhibitor radiotracer which demonstrated its suitability detecting cancer. Preparation conditions may influence quality and vivo behavior this tracer, no standard procedure for control (QC) available. The aim...
Background: Nowadays, in Nuclear Medicine, clinically applied radiopharmaceuticals must meet quality release criteria such as high radiochemical purity and yield. Many do not have marketing authorization no dedicated monograph within European Pharmacopeia (Ph. Eur.); therefore, general monographs on controls (QCs) to be for clinical application. These require standardization validation labeling preparation, including measurements, according well defined standard operation procedures....
Scintigraphy with 99mTc labelled heat-denatured erythrocyte (DRBC) allows non invasive diagnosis of heterotopic splenic tissue implantation (splenosis) following trauma or surgery. Single-photon emission computed tomography (SPECT) combined (CT) improves diagnostic accuracy planar imaging through a more precise localization functional findings. We report about two cases splenosis occurring many years after splenectomy. 99MTc-DCRBC scintigraphy was used for differential metasttic disease in...
Abstract Background The association between amyloid deposition and cognitive, behavioral physical performance in mild cognitive impairment (MCI) due to Alzheimer’s disease (AD) has been poorly investigated, especially older persons. Methods We studied the vivo correlation at Positron Emission Tomography (amyloid-PET) presence of memory loss, reduced executive function, neuropsychiatric symptoms persons with MCI. Amyloid-PET was performed 18F-flutemetamol quantitatively analyzed. Results...
Chemokine receptor-4 (CXCR4) is involved in tumor growth and progression several types of human cancer. Recently, [68Ga]-DOTA-Pentixafor has been assessed as an excellent imaging probe targeting CXCR4-expression using positron emission tomography (PET). Here we report on the entire production cycle [68Ga]-DOTA-Pentixafor, including quality control development process validation.Synthesis was validated via three independent consecutive runs automated synthesis system. All validation must pass...
Objective: To evaluate the prognostic role of maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) measured by FDG–positron emission tomography (PET)/computed (CT) in patients with primary lung adenocarcinoma undergoing surgical resection. Methods: All consecutive curative surgery for at Thoracic Surgery Unit University Hospital Parma between January 2009 December 2014 were retrospectively analyzed. The cutoff point each continuous PET...
Malignant pleural mesothelioma (MPM) is a rare and aggressive tumor with generally disappointing results in terms of survival, however, there are occasional long-term survivors probably due to the biologic characteristics disease. Standard uptake value (SUV) [ 18 F] Fluorodeoxyglucose (FDG) evaluated by photon emission tomography (PET) now widely accepted as an indicator behavior several malignancies. The aim this study was verify whether SUV max mean inversely associated prognosis patients...
Gallium-68 is a positron emitter for PET applications that can be produced without cyclotron by germanium (Ge-68) chloride/gallium (Ga-68) chloride generator. Short half-life (67.71 min) of Ga-68, matching pharmacokinetic properties small biomolecules, facilitates isotope utilization in compounding radiopharmaceuticals imaging. The increasing cost good manufacturing practice-compliant generators has strengthened the need radionuclide efficient use planning specific radiopharmaceutical...
Recently it has been identified a short peptide that showed allosteric antagonism against C-C motif chemokine receptor 2 (CCR2) expressed on inflammatory monocyte and macrophages. A 7-D-amino acid peptidic CCR2 inhibitor called extracellular loop 1 inverso (ECL1i), d(LGTFLKC) labeled to obtain new probe for positron emission tomography in pulmonary fibrosis, heart injury, abdominal aortic aneurysm inflammation, atherosclerosis, head neck cancer. Our goal was develop, optimize validate an...
Selective imaging of the splenic tissue is obtained with heat-damaged, or heat-denatured, red blood cells (RBCs) patient labeled 99mTc in a variety clinical scenarios. Aim study was to validate process used for labelling heat-damaged "totally vitro", after sample collection, before re-inject RBCs patient. Moreover, we assessed efficacy staff training programme order guarantee repeatibility and method standardization routine.The validation labeling procedure performed three different patients...
Background: Due to its overexpression in a variety of tumor types, the chemokine receptor 4 (CXCR4) represents highly relevant diagnostic and therapeutic target nuclear oncology. Recently, [ 68 Ga]Ga-DOTA-Pentixafor has emerged as an excellent imaging agent for positron emission tomography (PET) CXCR4 expression vivo. : Preparation conditions may influence quality vivo behaviour this tracer no standard procedure controls (QCs) is available. Objective: The developed analytical test method was...
Glucagon-like peptide 1 receptor (GLP-1R) is preferentially expressed in β-cells, but it highly human insulinomas and gastrinomas. Several GLP-1 receptor- avid radioligands have been developed to image insulin-secreting tumors or provide a quantitative vivo biomarker of pancreatic β-cell mass. Exendin-4 high affinity ligand the GLP1- R, which candidate for being labeled with PET isotope used imaging purposes.Here, we report development validation results semi-manual procedure label...
Gallium (Ga)-68-DOTA peptides targeting somatostatin receptors have been assessed as a valuable tool in neuroendocrine tumor imaging using positron emission tomography. However, at the moment, specific monograph European Pharmacopoeia (Ph. Eur.) does exist only for Ga-68-edotreotide (DOTATOC) injection. Here, we report on validation process of Ga-68-DOTA-Tyr3-octreotate (DOTATATE) cassette-based production and quality control (QC).Preparation Ga-68-DOTATATE was performed according to current...
Background: Titanium trabecular cages (TTCs) are emerging implants designed to achieve immediate and long-term spinal fixation with early osseointegration. However, a clear radiological clinical demonstration of their efficacy has not yet been obtained. The purpose this study was evaluate the reactive bone activity adjacent plates after insertion custom-made titanium for lumbar interbody positron emission tomography (PET)/computed (CT) 18F sodium fluoride (18F-NaF). Methods: This an...
In oligo-metastatic renal cell carcinoma (RCC), neither computed tomography (CT) nor bone scan is sensitive enough to detect small tumor deposits hampering early treatment and potential cure. Prostate-specific membrane antigen (PSMA) a transmembrane glycoprotein expressed in the neo-vasculature of numerous malignant neoplasms, including RCC, that can be targeted by positron emission (PET) using PSMA-targeting radioligands. Our aim was investigate whether PSMA-expression patterns cancer...
Labeled leukocytes with 99mTc-HMPAO are routinely used for infection imaging. Although cell labeling represents an imaging probe to detect sites, the diagnostic efficiency of is largely influenced by manipulation, multidisciplinary interventions (i.e., biologist, technicians) and available technology SPECT, SPECT/CT). The aim study was assess in vitro vivo accuracy a comprehensive approach quality assessment (QA) all steps procedure.Radiochemical purity (RCP), pH, (LE) were measured 320...
Background: Amyloid pathology is a key feature of Alzheimer’s disease (AD) and can be assessed in vivo with amyloid positron emission tomography (PET) imaging. Objective: The objective this study was to evaluate the incremental value PET scan [ 18 F]florbetaben, terms changes diagnosis, diagnostic confidence, treatment plan when added standardized workup for cognitive disorders, particular focus on role neuropsychological assessment, including Free Cued Selective Reminding Test (FCSRT)....
Background: Free and Cued Selective Reminding Test (FCSRT) is a reliable cognitive marker for Alzheimer’s disease (AD), the identification of neuropsychological tests sensitive to early signs AD pathology crucial both in research clinical practice. Objective: The study aimed ascertain ability FCSRT predicting amyloid load as determined from PET imaging (Amy-PET) patients with disorders. Methods: For our purpose, 79 (71 MCI, 8 mild dementia) underwent complete workup dementia, including...
Introduction and aim. Atypical or mixed presentations of neurodegenerative disorders may postpone confound the final diagnosis. Molecular imaging with positron emission tomography (PET) single photon computed (SPECT) radioligands provide target-specific information anticipate diagnosis by “in vivo” detection neuro pathological substrate, as Aβ deposition, nigrostriatal dopaminergic depletion tau inclusions. This concise review will dis cuss potential PET SPECT a solid guide to better...