A5043212909- Merger and Competition Analysis
- Lung Cancer Treatments and Mutations
- Digital Platforms and Economics
- Global trade and economics
- PI3K/AKT/mTOR signaling in cancer
- Social Sciences and Governance
- European and International Law Studies
- Melanoma and MAPK Pathways
- ICT Impact and Policies
- European and International Contract Law
- Corporate Governance and Law
- Consumer Market Behavior and Pricing
- 3D Printing in Biomedical Research
- Metabolomics and Mass Spectrometry Studies
- Additive Manufacturing and 3D Printing Technologies
- Global Financial Regulation and Crises
- Law, Economics, and Judicial Systems
- Protein Tyrosine Phosphatases
- Economic Theory and Institutions
- Global Trade and Competitiveness
- Colorectal Cancer Treatments and Studies
- Intellectual Property Law
- Taxation and Legal Issues
- Anatomy and Medical Technology
- Big Data Technologies and Applications
Charles River Associates
2012-2021
University of Parma
2013-2020
Charles River Laboratories (United Kingdom)
2017-2020
Dana-Farber Cancer Institute
2017-2018
Mario Negri Institute for Pharmacological Research
2011
Microsoft (United States)
2005
HER-2 represents a relatively new therapeutic target for non small cell lung cancer (NSCLC) patients. The incidence reported overexpression/amplification/mutations ranges from 2 to 20% in NSCLC. Moreover, amplification is potential mechanism of resistance tyrosine kinase inhibitors the epidermal growth factor receptor (EGFR-TKI) (about 10% cases). T-DM1, trastuzumab emtansine an antibody-drug conjugate composed by monoclonal antibody and microtubule polymerization inhibitor DM1. activity...
Background BCRP/ABCG2 emerged as an important multidrug resistance protein, because it confers to several classes of cancer chemotherapeutic agents and a number novel molecularly-targeted therapeutics such tyrosine kinase inhibitors. Gefitinib is orally active, selective EGFR inhibitor used in the treatment patients with advanced non small cell lung (NSCLC) carrying activating mutations. Membrane transporters may affect distribution accumulation gefitinib tumour cells; particular reduced...
Abstract The design of 3D complex structures enables new correlation studies between the engineering parameters and biological activity. Moreover, additive manufacturing technology could revolutionise personalised medical pre-operative management due to its possibility interplay with computer tomography. Here we present a method based on rapid freeze prototyping (RFP) printer, reconstruction cutting, nano dry formulation, fast gelation, disinfection partial processes for 5D digital models...
Despite the initial response, all patients with epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) eventually develop acquired resistance to EGFR tyrosine kinase inhibitors (TKIs). The EGFR-T790M secondary mutation is responsible for half of cases, while MET amplification has been associated in about 5-15% NSCLCs. Clinical findings indicate retained addiction resistant tumors on signaling. Therefore, we evaluated molecular mechanisms supporting therapeutic...
A prominent role in the pathogenesis of squamous cell carcinoma lung (SQCLC) has been attributed to aberrant activation PI3K signaling pathway, due amplification or mutations p110α subunit class I phosphatidylinositol 3-kinase (PIK3CA) gene. The aim our study was determine whether different genetic alterations PIK3CA affect biologic properties SQCLC and evaluate response specific targeting agents vitro vivo. effects NVP-BEZ235, NVP-BKM120, NVP-BYL719 on two-dimensional/three-dimensional...
// Claudia Fumarola 1 , Daniele Cretella Silvia La Monica Mara A. Bonelli Roberta Alfieri Cristina Caffarra Federico Quaini Denise Madeddu Angela Falco Andrea Cavazzoni Graziana Digiacomo Giulia Mazzaschi Valentina Vivo 2 Elisabetta Barocelli Marcello Tiseo 3 Pier Giorgio Petronini 1, * and Ardizzoni 4, Department of Medicine Surgery, University Parma, Italy Food Drug Department, Medical Oncology Unit, Hospital 4 Division Oncology, Sant'Orsola-Malpighi Hospital, Bologna, Joint last authors...
(2005). Economic Theories of Bundling and Their Policy Implications in Abuse Cases: An Assessment Light the Microsoft Case. European Competition Journal: Vol. 1, No. pp. 85-121.
We provide an economic rationalization for concerns that restrictions in the contracts between Google and manufacturers of mobile devices based on Android operating system have anti-competitive effects. extend recent insights tying two-sided markets (by Choi Jeon), showing Google’s app store with its search (and revenue sharing agreements which compensate exclusivity) can protect increase profits from advertising, help it outbid or marginalize other engines. Two-sidedness some pricing...
A common view in antitrust analysis is that mergers of complements can have raising rivals' costs and elimination double marginalization effects, with the net effect on consumer welfare thus unclear. We revise this context a merger between monopolist one market duopoly producer complement good. With linear demand imperfect substitutability, while such increases price monopolized component, dominates any increasing welfare. discuss variety extensions.
Theories of bundling have gained enormous prominence in European competition policy a number recent cases, concerning both merger control and abuse dominance. Prominent controversial examples include GE/Honeywell, Tetra Laval/Sidel the Microsoft decision which Commission ordered unbundling Windows Media Player from Windows. In this paper we attempt to sketch how systematic approach cases can be structured. For that purpose first provide an overview existing theories, concentrating on key...
Abstract KRAS is the most frequently mutated RAS family member. Within non-small cell lung cancer (NSCLC), G12C prevalent mutation (~13%) and inhibitors (G12Ci) sotorasib adagrasib are now FDA approved. However, it has been shown that simultaneous targeting of multiple nodes in MAPK pathway may be optimal for deeper more durable responses. Furthermore, acquired mutations occur clinically upon progression on or adagrasib, altogether supporting need clinical combinations with G12Ci. Based...
The increasing use of economics by competition authorities has inevitably led to an increase in the law cases before courts. Although this development been gathering pace, it is not without difficulties. courts still remain considerably less economically sophisticated than many authorities. Particularly non-specialist tend be unfamiliar with analytical framework much policy analysis, and can lead over-reliance on court's intuition, occasionally detriment ultimate decision. In addition, given...