A5048829750- Mast cells and histamine
- Cell Adhesion Molecules Research
- T-cell and B-cell Immunology
- Software-Defined Networks and 5G
- Internet Traffic Analysis and Secure E-voting
- Zebrafish Biomedical Research Applications
- Network Traffic and Congestion Control
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive Biology and Fertility
- Developmental Biology and Gene Regulation
- Pluripotent Stem Cells Research
- Reproductive Health and Technologies
Max Planck Institute of Immunobiology and Epigenetics
2022-2024
University of Freiburg
1985-2024
Universität der Bundeswehr München
2021
Prisma Health
2005
Clemson University
2005
Abstract Immune cell locomotion is associated with amoeboid migration, a flexible mode of movement, which depends on rapid cycles actin polymerization and actomyosin contraction 1 . Many immune cells do not necessarily require integrins, the major family adhesion receptors in mammals, to move productively through three-dimensional tissue spaces 2,3 Instead, they can use alternative strategies transmit their actin-driven forces substrate, explaining migratory adaptation changing external...
Neutrophils are sentinel immune cells with essential roles for antimicrobial defense. Most of our knowledge on neutrophil tissue navigation derived from wounding and infection models, whereas allergic conditions remained largely neglected. Here, we analyzed allergen-challenged mouse tissues discovered that degranulating mast (MCs) trap living neutrophils inside them. MCs release the attractant leukotriene B4 to re-route toward them, thus exploiting a chemotactic system normally use...
Abstract Actin network dynamics are pivotal in governing the motility and effector functions of immune cells. The Arp2/3 complex is a key regulator actin filament branching, with mutations its subunits being linked human immunodeficiencies. While known for role phagocytosis cell migration, our study uncovers critical safeguarding tissue residency mast cells (MCs), essential allergies, venom detoxification antigen-specific avoidance. Mechanistically, we show that MCs require Arp2/3-regulated...
In this paper, we argue that the design of a responsible Internet requires clear understanding current state deployment. This work sheds light on default routing in Internet, strategy reduces control but may help to increase availability when forwarding packets. We revisit and extend two common methodologies based active measurements coverage accuracy. Our results show larger differences between methodologies. confirm route deployment strongly correlates with customer cone size autonomous...
SUMMARY Many leukocytes use fast and flexible amoeboid migration strategies to move autonomously throughout tissues. Here, we show that the movement of mast cells (MCs), with important roles during allergies anaphylaxis, fundamentally differs from this rapid adhesion-free leukocyte migration. We identify a crucial role for integrin-dependent adhesion in controlling slow MC movement, which shapes positioning network-like tissue distribution long-lived immune cell type. In contrast other...