A5060140218- Virus-based gene therapy research
- Herpesvirus Infections and Treatments
- Face recognition and analysis
- Advanced Vision and Imaging
- Calcium signaling and nucleotide metabolism
- Cell death mechanisms and regulation
- Monoclonal and Polyclonal Antibodies Research
- CAR-T cell therapy research
- Photodynamic Therapy Research Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Inflammasome and immune disorders
- Face and Expression Recognition
- Genomics, phytochemicals, and oxidative stress
- Advanced Image and Video Retrieval Techniques
- Genetics, Aging, and Longevity in Model Organisms
- 3D Shape Modeling and Analysis
- Retinoids in leukemia and cellular processes
- Ferroptosis and cancer prognosis
- Peptidase Inhibition and Analysis
- FOXO transcription factor regulation
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Ubiquitin and proteasome pathways
- CRISPR and Genetic Engineering
- Adenosine and Purinergic Signaling
Yangtze University
2016-2025
Yunnan University
2024
Temasek Life Sciences Laboratory
2021
National University of Singapore
2021
Jingzhou Central Hospital
2017-2019
The 309th Hospital of Chinese People's Liberation Army
2013-2015
Hewlett-Packard (United States)
2011-2015
Brain (Germany)
2015
Chinese PLA General Hospital
2015
PLA 306 Hospital
2013
This paper presents a novel system to estimate body pose configuration from single depth map. It combines both detection and refinement. The input map is matched with set of pre-captured motion exemplars generate estimation, as well semantic labeling the point cloud. initial estimation then refined by directly fitting observation (e.g., depth). In addition new architecture, our other contributions include modifying cloud smoothing technique deal very noisy maps, alignment search algorithm...
Forkhead box class O 3a (FOXO3a) is a transcription factor that has emerged as being tumor suppressor and longevity factor. The precise regulation of FOXO3a transactivation target genes achieved via post-translational modifications (PTMs) specific protein‑protein interactions. multiple types PTMs undergoes, including phosphorylation, acetylation, methylation ubiquitination, serve important roles in directing its subcellular localization activity, which are central to the integration...
Automatic clothes search in consumer photos is not a trivial problem as are usually taken under completely uncontrolled realistic imaging conditions. In this paper, novel framework presented to tackle issue by leveraging low-level features (e.g., color) and high-level (attributes) of clothes. First, content-based image retrieval(CBIR) approach based on the bag-of-visual-words (BOW) model developed our baseline system, which codebook constructed from extracted dominant color patches. A...
Forkhead box O (FOXO) transcription factors play an important role in physiological and pathological processes. Extracellular signal-regulated kinase (ERK) protein B (Akt) can phosphorylate FOXO cause its degradation or cytoplasmic retention, respectively, leading to tumorigenesis. In addition, C-Jun N-terminal (JNK) promote nuclear localization, apoptosis. Using confocal imaging of cells transfected with GFP-FOXO3a, we visualized the dynamic translocation GFP-FOXO3a from cytoplasm nucleus...
Objective To ascertain accurate measurements of, and the relationships between, normative parameters of tracheobronchial trees in Chinese population using multi-slice spiral computed tomography (CT) multi-planar reconstruction (MPR). Materials Methods Measurements were performed on 2107 patients who underwent thoracic CT scans PLA General Hospital. The lengths trachea main stem bronchi, sizes subcarinal angle obtained through or MPR imaging. Multi-variance analyses to detect potential...
CD38, as a cell surface antigen is highly expressed in several hematologic malignancies including multiple myeloma (MM) and has been proven to be good target for immunotherapy of the disease. CD38 also signaling enzyme responsible metabolism two novel calcium messenger molecules. To able this multifunctional protein, we generated series nanobodies against with high affinities. Crystal structures complexes were solved, identifying three separate epitopes on carboxyl domain. Chromobodies,...
Active stereo vision is a method of 3D surface scanning involving the projecting and capturing series light patterns where depth derived from correspondences between observed projected patterns. In contrast, passive reveals through textured images two or more cameras. By employing projector, active systems find cameras, without ambiguity, independent object texture. this paper, we present hybrid reconstruction framework that supplements pattern correspondence matching with texture...
Automatic personal clothing retrieval on photo collections, i.e., searching the same clothes worn by person, is not a trivial problem as photos are usually taken under completely uncontrolled realistic imaging conditions. Typically, captured images have large variations due to geometric deformation, occlusion, cluttered background, and photometric variability from illumination viewpoint, which pose significant challenges text-based or reranking-based visual search methods. In this paper,...
Inflammation and atherosclerosis (AS) are closely associated to Secreted Protein Acidic Rich in Cysteine (SPARC) its related factors. This study attempted define the role potential mechanism of SPARC factors ameliorating hyperlipidemia AS by aerobic exercise intervention. The rat model was established with a high-fat diet plus vitamin D3 intraperitoneal injection. Treadmill exercises training (5 days/week at 14 m/min for 60 min/day) 6 weeks carried out intervention method. Western blotting...
Abstract Growing evidence underscores the pivotal impact of crosstalk between leukemic stem cells (LSCs) and mesenchymal stromal (MSCs) within their niche on leukemia initiation, progression, therapy response. Although MMP14 plays an important role in inflammation cancer, regulation MSC-derived acute myeloid (AML) are largely unknown. Here, we found that AML patient-derived MSCs (AML-MSCs) were more supportive cell growth compared to healthy donor-derived (HD-MSCs). Moreover, AML-MSCs...
Hypoxia-inducible factor-1α (HIF-1α), a master regulator of cellular adaptation to hypoxia, drives colorectal cancer (CRC) progression by fueling angiogenesis, metastasis, and therapy resistance. Emerging evidence delineates intricate crosstalk between non-coding RNAs (ncRNAs)—including microRNAs, long RNAs, circular RNAs—and HIF-1α, forming bidirectional regulatory networks that orchestrate CRC pathogenesis. By interacting with these contribute the orchestration aggressive hypoxic tumor...
The extraction of effective classification features from high-dimensional hyperspectral images, impeded by the scarcity labeled samples and uneven sample distribution, represents a formidable challenge within image classification. Traditional few-shot learning methods confront dual dilemma limited annotated necessity for deeper, more complex data, often resulting in suboptimal outcomes. prohibitive cost annotation further exacerbates challenge, making it difficult to rely on scant number...
It has been suggested that drugs combining activities of selective serotonin reuptake inhibitor and 5-HT1A receptor agonist may form a novel strategy for higher therapeutic efficacy antidepressant. The present study aimed to examine the pharmacology YL-0919, synthetic compound with combined high affinity selectivity transporter receptors. We performed in vitro binding function assays vivo behavioral tests assess pharmacological properties antidepressant-like YL-0919. YL-0919 displayed both...