A5102756971- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Liver Disease and Transplantation
- Renin-Angiotensin System Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiac Fibrosis and Remodeling
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Liver Disease Diagnosis and Treatment
- Cardiovascular Issues in Pregnancy
- MicroRNA in disease regulation
- Opinion Dynamics and Social Influence
- Bone health and treatments
- Liver physiology and pathology
- Cardiomyopathy and Myosin Studies
- Inflammasome and immune disorders
- Lipid metabolism and disorders
- Thyroid Disorders and Treatments
- Renal function and acid-base balance
- Supramolecular Chemistry and Complexes
- Immune Cell Function and Interaction
- Diabetes and associated disorders
- Mathematical and Theoretical Epidemiology and Ecology Models
- RNA modifications and cancer
- Metabolism and Genetic Disorders
- Hemodynamic Monitoring and Therapy
University of California, San Diego
2020-2024
University of Arizona
2014-2022
Indiana University – Purdue University Indianapolis
2022
Health Affairs
2015-2017
Pulmonary Hypertension Association
2017
Vanderbilt University
2017
Wayne State University
2017
Regenerative Medicine Institute
2017
Missouri Western State University
2013
University of Illinois Chicago
2010-2011
Abstract Idiopathic pulmonary arterial hypertension (IPAH) is a rare but fatal disease diagnosed by right heart catheterisation and the exclusion of other forms hypertension, producing heterogeneous population with varied treatment response. Here we show unsupervised machine learning identification three major patient subgroups that account for 92% cohort, each unique whole blood transcriptomic clinical feature signatures. These are associated poor, moderate, good prognosis. The poor...
In this paper, a modified SIS epidemic model is proposed to study the dynamics of virus spread in wireless sensor networks. The nodes are attacked by viruses and initially only small number infected. spreads itself its neighbour piggybacking on normal data via regular communications. infected repeat process their respective nodes. Each node installed with an antivirus program, which can be periodically refreshed recover infective susceptible group. Some explicit solutions derived, capture...
Using RNAseq, we identified a 61 gene‐based circulating transcriptomic profile most correlated with four indices of pulmonary arterial hypertension severity. In an independent dataset, 13/61 (21%) genes were differentially expressed in lung tissues cases versus controls, highlighting potentially novel candidate involved development.
Idiopathic pulmonary arterial hypertension (IPAH) remains a devastating and deadly disease with poor long-term prognosis. The median survival for untreated patients is only 2.8 years, pitiful three-year, five-year, seven-year rates of 68%, 57%, 49%, respectively.1 goal breakthrough discovery leading to meaningfully life-extending treatment protocol has not yet been achieved, as the exact pathogenic mechanisms (PAH) are too complex current understanding. Research has, on bright side, yielded...
Metabolic abnormalities in pulmonary endothelial cells are implicated hypertension (PH) while increasing evidence shows the influence of diabetes on progressing PH. In this study, we examined effect type 2 hypoxia-induced PH and investigated its molecular mechanisms using diabetic male mice. Chronic hypoxia led to a more severe mice than control Next, compared gene expression patterns isolated (MPECs) from normoxia (CN), (DN), exposed (CH), (DH). The results showed that levels 27 mRNAs, out...
Abstract The pulmonary circulation is a low resistance and pressure system. Sustained vasoconstriction excessive vascular remodeling often occur under pathophysiological conditions such as in patients with hypertension. Pulmonary consequence of smooth muscle contraction. Many factors released from the endothelium contribute to regulating tone, while extracellular matrix adventitia major determinant wall compliance. characterized by adventitial medial hypertrophy due fibroblast cell...
Just over 4 years ago we launched Pulmonary Circulation. Since then have grown steadily as a journal, occupying an important niche and serving the clinical research communities in our field. Our aim has been continues to be publish timely novel provide in-depth reviews community of clinicians researchers involved work finding cures for deadly diseases such pulmonary arterial hypertension. There exists great need medical around globe up-to-date, relevant information on latest field vascular...
Like a frontier, science is vast; it's endless. And like pioneer entering new land, when scientist gazes across that expansive space, he sees opportunity and freedom to pursue his thoughts interests. Broadly speaking, there are two main types of scientists: the “basic” scientist, clinician. The basic most in has range work, but unfortunately not always opportunity. clinician town doctor; access all clinical material, or knowledge research necessary. But what happens collaborates with...
This summer, the Pulmonary Vascular Research Institute (PVRI) celebrates its ten-year anniversary. The bold mission of PVRI is: “to reduce global burden pulmonary vascular disease within next two decades.” has three primary objectives: to improve care patients all over world who suffer from disease; facilitate and accelerate research in clinical basic science encourage development new therapies. Timely publication advances basic, translational, on is a critical way achieve these objectives....
Introduction Pulmonary arterial hypertension (PAH) is characterized by increased pulmonary artery (PA) pressure and resistance due to vascular remodeling. The functional effect of this remodeling on the pulsatile hemodynamics has not been well studied. impedance (PVZ) represents relationship between flow in provides a more comprehensive view function. We hypothesized that decreased compliance (PVR) would significantly alter severe PAH. Methods Group 1 PAH patients (mean (mPAP) ≥ 25 mmHg,...