A5037793435- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Agricultural pest management studies
- Single-cell and spatial transcriptomics
- Genetics and Plant Breeding
- Nanoparticles: synthesis and applications
- Epigenetics and DNA Methylation
- CRISPR and Genetic Engineering
- Pluripotent Stem Cells Research
- Genetic and Environmental Crop Studies
- Allelopathy and phytotoxic interactions
- Protein Degradation and Inhibitors
- Advanced biosensing and bioanalysis techniques
- Plant Stress Responses and Tolerance
- Crop Yield and Soil Fertility
- Hematopoietic Stem Cell Transplantation
- Medicinal Plants and Neuroprotection
- Histone Deacetylase Inhibitors Research
- Advanced Nanomaterials in Catalysis
- Advanced Biosensing Techniques and Applications
- Plant-Microbe Interactions and Immunity
- Diverse Scientific Research Studies
- Rice Cultivation and Yield Improvement
- Agricultural Science and Fertilization
- Immune cells in cancer
Institute for Research in Biomedicine
2024-2025
Universitat de Barcelona
2025
Barcelona Institute for Science and Technology
2024
Shanghai Institute for Science of Science
2024
Dr. Hari Singh Gour University
2022
Hebrew University of Jerusalem
2021
Summary Current approaches to lineage tracing of stem cell clones require genetic engineering or rely on sparse somatic DNA variants, which are difficult capture at single-cell resolution. Here, we show that targeted measurements methylation single-CpG resolution deliver joint information about cellular differentiation state and clonal identities. We develop EPI-clone, a droplet-based method for transgene-free tracing, apply it study hematopoiesis, capturing hundreds trajectories across...
Cancer cells display wide phenotypic variation even across patients with the same mutations. Differences in cell of origin provide a potential explanation, but traditional assays lack resolution to distinguish clonally heterogeneous subsets stem and progenitor cells. To address this challenge, we developed simultaneous tracking recombinase activation clonal kinetics (STRACK), method trace dynamics gene expression before after acquisition cancer Using mouse models, studied two leukemic...
Myocardial infarction (MI) is a major global health concern. Although myeloid cells are crucial for tissue repair in emergency haematopoiesis after MI, excessive myelopoiesis can exacerbate scarring and impair cardiac function. Bone marrow (BM) haematopoietic stem (HSCs) have the unique capability to replenish system, but their role MI has not yet been established. Here we collected human sternal BM samples from over 150 surgery patients, selecting 49 with preserved We show that causes...
Cancer cells display wide phenotypic variation even across patients with the same mutations. Differences in cell of origin provide a potential explanation, but these assays have traditionally relied on surface markers, lacking clonal resolution to distinguish heterogeneous subsets stem and progenitor cells. To address this challenge, we developed STRACK, an unbiased framework longitudinally trace gene expression expansion dynamics before after acquisition cancer We studied two different...
Cancer cells display wide phenotypic variation even across patients with the same mutations. Differences in cell of origin provide a potential explanation, but these assays have traditionally relied on surface markers, lacking clonal resolution to distinguish heterogeneous subsets stem and progenitor cells. To address this challenge, we developed STRACK, an unbiased framework longitudinally trace gene expression expansion dynamics before after acquisition cancer We studied two different...
Nanotechnology has today turned out to be a buzzword. Its expansion in different field is phenomenal. But for some reason, it been holding the rate of development. To count reason behind being its failure despite such promising properties high-cost production and potential harm nature. Beside less significant amount production, there need eco-friendly, toxic cleaner method production. It could not have more favorable, case if lead an increase at same time efficiency too. Algae mediated...
Silver nanoparticles are today considered as the backbone of nanotechnology industries. Since time immemorial silver along with its compound and associated salts have been walking together human civilization. Although has known from such a long it not recently that fabrication nanoparticle was to be reality. It some prominent well pronounced application in field medicine, agriculture etc. very favorable significant antioxidant, antibacterial antifungal properties. found effective against...
Self-renewing multipotent haematopoietic stem cells (HSCs) have the unique capacity to stably regenerate entire blood and immune systems following transplantation. HSCs are used clinically reconstitute a healthy system in patients suffering from range of haematological diseases. However, very rare been challenging grow ex vivo, which has hampered efforts collect large numbers for both basic research clinical therapies. Polymer-based culture conditions recently developed support expansion...
A field experiment was conducted during the winter season of 201011 at Pantnagar, to compare response gypsum and micronized sulphur in variety PBW 502 wheat [Triticum aestivum (L.) emend. Fiori & Paol.]. Microionized as soil application@ 60 kg/ha gave higher value shoot count, plant height, dry-matter ac- cumulation yield attributes yield, NPK S uptake, quality parameters like grain protein, starch, wet glu- ten, sedimentation value, hectolitre weight economics parameters, viz. gross...