A5050847152- Graphene and Nanomaterials Applications
- Advanced Sensor and Energy Harvesting Materials
- Electrospun Nanofibers in Biomedical Applications
- Spaceflight effects on biology
- Nanoparticles: synthesis and applications
- Advanced Nanomaterials in Catalysis
- Bone Tissue Engineering Materials
- Boron and Carbon Nanomaterials Research
- Neuroscience and Neural Engineering
- 3D Printing in Biomedical Research
- Conducting polymers and applications
- Nanoplatforms for cancer theranostics
- Space Exploration and Technology
- Molecular Communication and Nanonetworks
- Genetics, Aging, and Longevity in Model Organisms
- MXene and MAX Phase Materials
- Connective tissue disorders research
- Anesthesia and Neurotoxicity Research
- Nerve injury and regeneration
- Space Science and Extraterrestrial Life
- Sirtuins and Resveratrol in Medicine
- Tissue Engineering and Regenerative Medicine
- Planarian Biology and Electrostimulation
- TiO2 Photocatalysis and Solar Cells
- Carbon and Quantum Dots Applications
Piaggio (Italy)
2013-2025
Piaggio Aerospace (Italy)
2014-2025
Italian Institute of Technology
2016-2025
Interface (United States)
2025
University of Bari Aldo Moro
2024
Center for Micro-BioRobotics
2012-2021
Scuola Superiore Sant'Anna
2011-2016
University of California, San Francisco
2016
Poly(vinylidene fluoride‐trifluoroethylene, P(VDF‐TrFE)) and P(VDF‐TrFE)/barium titanate nanoparticle (BTNP) films are prepared tested as substrates for neuronal stimulation through direct piezoelectric effect. Films characterized in terms of surface, mechanical, features before vitro testing on SH‐SY5Y cells. In particular, BTNPs significantly improve properties the (4.5‐fold increased d 31 ). Both kinds support good viability differentiation. Ultrasound (US) is proven to elicit Ca 2+...
Electrical stimulation of cells and tissues is an important approach interaction with living matter, which has been traditionally exploited in the clinical practice for a wide range pathological conditions, particular, related to excitable tissues. Standard methods are, however, often invasive, being based on electrodes wires used carry current intended site. The possibility achieve indirect electrical stimulation, by means piezoelectric materials, therefore outstanding interest all...
Ceramic materials based on perovskite-like oxides have traditionally been the object of intense interest for their applicability in electrical and electronic devices. Due to its high dielectric constant piezoelectric features, barium titanate (BaTiO3) is probably one most studied compounds this family. Recently, an increasing number studies focused exploitation nanoparticles (BTNPs) biomedical field, owing biocompatibility BTNPs peculiar non-linear optical properties that encouraged use as...
This study aims at investigating the behavior in terms of proliferation and skeletal muscle differentiation capability two myoblastic cell lines, C2C12 H9c2, on both isotropic anisotropic electrospun nanofibrous poly(hydroxybutyrate) (PHB) scaffolds, as well PHB films polystyrene controls. After a careful characterization matrices surface morphology, roughness mechanical properties, rate lines to form myotubes were evaluated. Genetic analyses also performed order assess level cells different...
Boron nitride nanotubes (BNNTs) have attracted huge attention in many different research fields thanks to their outstanding chemical and physical properties. During recent years, our group has pioneered the use of BNNTs for biomedical applications, first all assessing vitro cytocompatibility on cell lines. At this point, vivo investigations are necessary before proceeding toward realistic developments proposed applications. In communication, we report a pilot toxicological study rabbits....
Functional and stimuli-responsive nanofibers with an enhanced surface area/volume ratio provide controlled triggered drug release higher efficacy. In this study, chemotherapeutic agent Rose Bengal (RB) (4,5,6,7-tetrachloro-2', 4',5',7'-tetraiodofluoresceindisodium)-loaded water-soluble polyvinyl alcohol (PVA) were synthesized by using the electrospinning method. A thin layer of poly(4-vinylpyridine-co-ethylene glycol dimethacrylate) p(4VP-co-EGDMA) was deposited on RB-loaded (PVA-RB) via...
Liposomes were loaded with a polyphenol-rich extract from grape pomace. successfully crossed the BBB and efficiently protected neural cells neurodegeneration in relevant vitro models.
In the past decades, bone tissue engineering developed and exploited many typologies of bioreactors, which, besides providing proper culture conditions, aimed at integrating those bio-physical stimulations that cells experience in vivo, to promote osteogenic differentiation. Nevertheless, highly challenging combination deployment stimulation systems into a single bioreactor led generation several unimodal investigating one or mostly two required biophysical stimuli. These miss physiological...
The obtainment of innovative models recalling complex tumour architectures and activities in vitro is a challenging drive the understanding pathology molecular bases, yet crucial passage to identification targets for advanced oncotherapy. Cell environment recapitulation by 3D scaffolding gravitational unloading cell cultures represent powerful means biomimicry process, but their simultaneous adoption has consistently been explored only latest decade. Here, an unprecedented bioengineering...
In the last decade, importance of topographic properties extracellular environments has been shown to be essential addressing cell response, especially when replacing damaged tissues with functional constructs obtained in vitro. current study, densely packed sub-micron poly(3-hydroxybutyrate) (PHB) fibres were electrospun random and parallel orientations. PC12 pheochromocytoma cells that mimic central dopaminergic neurons represent a model for neuronal differentiation cultured on...
Altered gravity is a strong physical cue able to elicit different cellular responses, representing largely uninvestigated opportunity for tissue engineering/regenerative medicine applications. Our recent studies have shown that both proliferation and differentiation of C2C12 skeletal muscle cells can be enhanced by hypergravity treatment; given these results, PC12 neuron-like were chosen test the hypothesis stimulation might also affect behavior neuronal cells, in particular promoting an...
Mesoporous zinc oxide (ZnO) scaffolds coated with drop-cast graphene (GO) flakes are proposed to be a novel bilayer system featuring bioactivity, biocompatibility, and promising loading/release properties for controlled drug-delivery systems. The high-surface-area ZnO show clear apatite deposition, but their particular surface chemistry topography prevent the formation of continuous coating, resulting in micrometric crystalline aggregates after 28 days simulated body fluid (SBF). When...