A5021413492- Extracellular vesicles in disease
- Acute Myeloid Leukemia Research
- Hematological disorders and diagnostics
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- S100 Proteins and Annexins
- Protease and Inhibitor Mechanisms
- Autophagy in Disease and Therapy
- Telomeres, Telomerase, and Senescence
- Immune cells in cancer
- Circadian rhythm and melatonin
- Hematopoietic Stem Cell Transplantation
- Epigenetics and DNA Methylation
- Chronic Myeloid Leukemia Treatments
- Immune Response and Inflammation
- Cytokine Signaling Pathways and Interactions
- Calcium signaling and nucleotide metabolism
- Research on Leishmaniasis Studies
- Proteoglycans and glycosaminoglycans research
- Cancer, Hypoxia, and Metabolism
- Platelet Disorders and Treatments
- Caveolin-1 and cellular processes
- Acute Lymphoblastic Leukemia research
- Cancer-related Molecular Pathways
- Folate and B Vitamins Research
- Blood Coagulation and Thrombosis Mechanisms
Goethe University Frankfurt
2021-2024
University Medical Centre Mannheim
2024
Heidelberg University
2023-2024
University Hospital Heidelberg
2023-2024
Georg Speyer Haus
2017-2024
National and Kapodistrian University of Athens
2013
Inflammation promotes solid tumor progression, but how regulatory mechanisms of inflammation may affect leukemia is less well studied. Using annexin A5 (ANXA5), a calcium-binding protein known for apoptosis, which we discovered to be differentially expressed in the bone marrow microenvironment (BMM) mice with acute myeloid (AML) vs chronic leukemia, as model system, unravel here circuit AML-derived necrosis factor α (TNF-α) dose-dependently reduces ANXA5 BMM. This creates an inflammatory BMM...
BACKGROUND: Advanced age is unequivocally linked to the development of cardiovascular disease; however, mechanisms resulting in reduced endothelial cell regeneration remain poorly understood. Here, we investigated novel involved senescence that impact transcription and vascular repair after injury. METHODS: Native cells were isolated from young (20±3.4 years) aged (80±2.3 individuals subjected molecular analyses assess global transcriptional metabolic changes. In vitro studies conducted...
Recent studies have demonstrated the influence of clock genes in cell cycle regulation, proliferation, apoptosis and DNA damage recognition repair. There is evidence suggesting implication colorectal cancer (CRC) development progression. The aim this study to evaluate expression levels CRC correlate them with patients' prognosis. Forty-two samples (from 24 males 18 females), their paired noncancerous tissues 8 biopsies from healthy individuals were included. Quantitative real-time PCR was...
The circadian rhythm regulates the cell cycle progression and DNA damage response. aim of our study was to investigate association between polymorphisms in CLOCK1, PER2, PER3 genes with colorectal cancer (CRC) susceptibility clinicopathological variables.Four hundred two CRC patients 480 healthy controls were included a case-control study. Genotype allelic frequencies 311T>C (rs1801260) CLOCK1 gene, G3853A (rs934945) PER2 gene 4/5 repeats evaluated by polymerase chain reaction (PCR)...
Abstract Lipid raft-associated proteins play a vital role in membrane-mediated processes. The lipid microdomain-associated protein flotillin 2 (FLOT2), which has scaffolding function, is involved polarization, as well actin cytoskeletal organization of primitive and mature hematopoietic cells been associated with different malignancies. However, its involvement myeloid leukemias not studied. Using murine transplantation models, we show here that the absence FLOT2 from leukemia-initiating...
Abstract Leukemia cells reciprocally interact with their surrounding bone marrow microenvironment (BMM), rendering it hospitable to leukemia cell survival, for instance through the release of small extracellular vesicles (sEVs). In contrast, we show here that BMM deficiency pleckstrin homology domain family M member 1 (PLEKHM1), which serves as a hub between fusion and secretion intracellular is important vesicular in osteoclasts, accelerates murine BCR-ABL1+ B-cell acute lymphoblastic...
The lysosome is a cellular signalling hub at the point of convergence endocytic and autophagic pathways, where contents are degraded recycled. Pleckstrin homology domain-containing family member 1 (PLEKHM1) acts as an adaptor to facilitate fusion vesicles with lysosome. However, it unclear how PLEKHM1 function controlled. Herein, we show that coprecipitates with, directly phosphorylated by, mTOR. Using phosphospecific antibody against Ser432/S435 PLEKHM1, same motif direct target for...
Protein persulfidation is a significant post-translational modification that involves addition of sulfur atom to the cysteine thiol group and facilitated by sulfide species. Persulfidation targets reactive residues within proteins, influencing their structure and/or function across various biological systems. This evolutionarily conserved plays crucial role in preventing irreversible overoxidation, process becomes prominent with aging. While, decreases age, its levels aged heart functional...
Fibrinolysis influences the mobilization of hematopoietic stem cells from their bone marrow microenvironment (BMM). Here we show that activation plasmin, a key fibrinolytic agent, by annexin A2 (ANXA2) distinctly impacts progression BCR-ABL1+ B-cell acute lymphoblastic leukemia (B-ALL) via modulation extracellular matrix (ECM) in BMM. The dense ECM BMM with decreased plasmin activity entraps insulin-like growth factor (IGF) 1 and reduces mTORC2-dependent signaling proliferation B-ALL cells....
Protein persulfidation is a significant post-translational modification that involves addition of sulfur atom to the cysteine thiol group and facilitated by sulfides. Persulfidation targets reactive residues within proteins, influencing their structure and/or function across various biological systems. This evolutionarily conserved plays crucial role in preventing irreversible overoxidation, process becomes prominent with aging. In heart, decreases age, but functional implications such...