A5031571372- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- Neonatal Respiratory Health Research
- Liver Disease Diagnosis and Treatment
- CAR-T cell therapy research
- Lung Cancer Research Studies
- Sperm and Testicular Function
- Neurogenesis and neuroplasticity mechanisms
- Pancreatic function and diabetes
- Pulmonary Hypertension Research and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Liver physiology and pathology
- Hormonal and reproductive studies
- Multiple Sclerosis Research Studies
- Mesenchymal stem cell research
- Reproductive Biology and Fertility
- Cancer, Hypoxia, and Metabolism
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer Research and Treatments
- Diabetes Treatment and Management
- Lung Cancer Treatments and Mutations
- Advanced Neuroimaging Techniques and Applications
- Respiratory Support and Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Immunotherapy and Biomarkers
Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences
2024-2025
Research Institute of Pharmacology and Regenerative Medicine named ED Goldberg
2016-2024
Tomsk National Research Medical Center
2018-2024
Russian Academy of Sciences
2018-2024
National Research Tomsk State University
2015-2019
Macromolecular proton fraction (MPF) has been established as a quantitative clinically-targeted MRI myelin biomarker based on recent demyelination studies. This study aimed to assess the capability of MPF quantify remyelination using murine cuprizone-induced reversible model. was measured in vivo fast single-point method three animal groups (control, demyelination, and after cuprizone withdrawal) compared immunohistochemistry for basic protein (MBP), myelinating oligodendrocytes...
CD8+ T-lymphocytes play a key role in antitumor immune response. Patients with lung cancer often suffer from T-lymphocyte dysfunction and low T-cell counts. The exhaustion of effector largely limits the effectiveness therapy. In this study, reprogrammed used MEK inhibitors PD-1 blockers to increase their activity. Antitumor effects were shown vitro vivo Lewis carcinoma model. population T- lymphocytes persistent expression CCR7 was formed as result reprogramming. Reprogrammed resistant...
In clinical practice, there are patients with a combination of metabolic syndrome (MS) and chronic obstructive pulmonary disease (COPD). The pathological mechanisms linking MS COPD largely unknown. It remains unclear whether the effect (possible obesity) has major impact on progression COPD. This complicates development effective approaches for treatment diagnosis Experiments were performed female C57BL/6 mice. Introduction monosodium glutamate extract cigarette smoke was modeled to simulate...
Recent studies showed hepatoprotective, neuroprotective, and immunomodulatory properties of polyprenols isolated from the green verdure Picea abies (L.) Karst. This study aimed to investigate effects on oligodendrogenesis, neurogenesis, myelin content in cuprizone demyelination model. Demyelination was induced by 0.5% CD-1 mice during 10 weeks. Nine cuprizone-treated animals received daily injections intraperitoneally at a dose 12-mg/kg body weight Weeks 6-10. control other nine sham oil...
Endothelial dysfunction and destruction of the pulmonary microcirculation are important pathogenic factors in chronic obstructive disease (COPD). In COPD, bronchial obstruction is associated with endothelial dysfunction. Thus, new pharmacological treatment options aimed at restoring endothelium represent a clinical need COPD therapy. Notch1 has been shown to protect cells against apoptosis, inflammation, oxidative stress caused by cigarette smoke extract (CSE). Therefore, drug which effect...
The enhancement of early diagnosis lung cancer is mandatory to improve prognosis. We observed the increase stem cells (CSC) and circulating tumor (CTC) in blood mice on d3 after Lewis carcinoma (LLC) cell implantation before disease symptom. Besides we have developed an approach reprogramming immune by inhibiting MAPK/ERK pathway through MEKi PD-1/PD-L1 checkpoint signaling pathway. hypothesized that spleen CD8+ T-cells could also create a population with high antitumor activity....
Awareness of age-related features carcinogenesis and the importance cellular immunity is crucial for developing effective antitumor therapies specific patient groups.
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease characterized by interstitial and respiratory failure. Pirfenidone nintedanib slow down but do not stop the progression of IPF. Thus, new compounds with high antifibrotic activity simultaneously regenerative are an unmet clinical need. Recently, we showed that Treamid can help restoring pancreas testicular tissue in mice metabolic disorders. We hypothesized may be effective therapy regeneration damaged lung fibrosis. In...
Using a model of Lewis lung carcinoma (LLC) in vitro and vivo, we previously demonstrated increased antitumor activity CD8+ T-cells reprogrammed with an MEK inhibitor PD-1 blocker. In this follow-up study, carried out the reprogramming human (hrT-cell) using blocker targeted LLC cells. The effects hrT-cell therapy were studied mouse spontaneous metastasis solid tumor. We found antimetastatic hrT-cells, decrease number cancer cells stem lungs, increase blood (including effector T-cells)....
Concentration of hyaluronic acid (HA) in the lungs increases idiopathic pulmonary fibrosis (IPF). HA is involved organization fibrin, fibronectin, and collagen. has been proposed to be a biomarker potential target for antifibrotic therapy. Hyaluronidase (HD) breaks down into fragments, but subject rapid hydrolysis. A conjugate poloxamer hyaluronidase (pHD) was prepared using protein immobilization with ionizing radiation. In model bleomycin-induced fibrosis, pHD decreased level tissue IL-1β...
New drug targets, markers of disease prognosis, and more efficient treatment options are an unmet clinical need in breast cancer (BC). We have conducted a pilot study including patients with luminal B stage IIA–IIIB. The presence frequency various populations stem cells (CSC) somatic were assessed the blood, tumor tissue, normal tissue. Our results suggest that BC can be divided into two distinct groups based on aldehyde dehydrogenase positive (ALDH1+ cells) blood (ALDH1hi ALDH1low). In...
In clinical practice, the metabolic syndrome (MetS) is often associated with chronic obstructive pulmonary disease (COPD). Although gender differences in MetS are well documented, little known about sex-specific pathogenesis of COPD, especially when combined MetS. Consequently, it not clear whether same treatment regime has comparable efficacy men and women diagnosed COPD. present study, using sodium glutamate, lipopolysaccharide, cigarette smoke extract, we simulated lipid metabolism...
In clinical practice, the metabolic syndrome can lead to multiple complications, including diabetes. It remains unclear which component of (obesity, inflammation, hyperglycemia, or insulin resistance) has strongest inhibitory effect on stem cells involved in beta cell regeneration. This makes it challenging develop effective treatment options for complications such as our study, experiments were performed male C57BL/6 mice where disorders have been introduced experimentally by a combination...
Current methods for diagnosis and treatment of small cell lung cancer (SCLC) have only a modest efficacy. In this pilot study, we analyzed circulating tumor cells (CTCs) stem (CSCs) in patients with SCLC to search new diagnostic prognostic markers novel approaches improve the disease. other forms cancer, showed heterogeneity blood CTCs CSCs populations, as well changes populations (ALDH+, CD87+CD276+, EGF+Axl+) smokers. A number been shown be resistant chemotherapy (CT). High cytotoxic...
The processes of proliferation and differentiation progenitor stem cells in the body are ensured by a specific microenvironment, cell niche. Universal components have been identified for all niches: supporting cells, extracellular matrix, soluble biological factors. A niche is dynamic system whose activity depends on regeneration needs. review presents data structure hepatic one its main – stellate their role pathology.
Abstract Background Metastatic disease is a major and difficult-to-treat complication of lung cancer. Considering insufficient effectiveness existing therapies taking into account the current problem cancer chemoresistance, it necessary to continue development new treatments. Methods Previously, we have demonstrated antitumor effects reprogrammed CD8 + T-cells (rCD8 T-cells) from spleen in mice with orthotopic carcinoma. Reprogramming was conducted by inhibiting MAPK/ERK signalling pathway...