A5103019032- Pituitary Gland Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Sarcoma Diagnosis and Treatment
- Soft tissue tumors and treatment
- Glioma Diagnosis and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Cancer Diagnosis and Treatment
- Parathyroid Disorders and Treatments
- Ear and Head Tumors
- Neurofibromatosis and Schwannoma Cases
- Bone Tumor Diagnosis and Treatments
- Tumors and Oncological Cases
- melanin and skin pigmentation
- Genetic Syndromes and Imprinting
- Neuroblastoma Research and Treatments
- Blood disorders and treatments
- Cancer and Skin Lesions
- Medical Imaging and Pathology Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Infectious Diseases and Mycology
- Musculoskeletal synovial abnormalities and treatments
- Teratomas and Epidermoid Cysts
- Ocular Oncology and Treatments
- Salivary Gland Disorders and Functions
- Heparin-Induced Thrombocytopenia and Thrombosis
Hospital de Santa Maria
2015-2025
Centro Hospitalar Lisboa Norte
2018-2022
Objective To investigate whether the balance of blood follicular helper T (Tfh) cells and regulatory (Tfr) can provide information about ectopic lymphoid neogenesis disease activity in primary Sjögren's syndrome ( SS ). Methods We prospectively recruited 56 patients clinically suspected having . Sixteen these subsequently fulfilled American–European Consensus Group criteria for were compared to 16 with non‐ sicca syndrome. Paired minor salivary gland MSG ) biopsy samples analyzed study Tfr...
The crosstalk between tumour cells and microenvironment components in pituitary neuroendocrine tumours (PitNETs), including chemokines, may impact behaviour clinical outcomes. CCL2 was previously identified as a key chemokine PitNETs, but its role remains unknown. We aimed to study the of defining phenotype outcomes regulating macrophage chemotaxis, epithelial-to-mesenchymal transition (EMT) angiogenesis. studied E-cadherin expression, macrophages (CD68 CD163) vessels (CD31) samples from 86...
To study the role of fine needle aspiration cytology (FNAC) in diagnosis cutaneous and subcutaneous endometriosis.We present 7 cases endometriosis abdominal wall, inguinal region perineum diagnosed by FNAC. All were confirmed with histologic follow-up. Cytologic material was prepared using standard methods.The smears highly cellular, showing a hemorrhagic background hemosiderin-laden macrophages sheets epithelial stromal cells. Occasionally, these cellular components closely associated.FNAC...
Sarcomas are rare malignant mesenchymal neoplasms, and the knowledge of tumor biology genomics is scarce. Chemotherapy standard care in advanced disease, with poor outcomes. Identifying actionable genomic alterations may offer effective salvage therapeutic options when previous lines have failed. Here, we report a retrospective cohort study sarcoma patients followed at our center submitted to comprehensive profiling between January 2020 June 2021. Thirty were included, most (96.7%)...
Introduction: Schwannomas—Schwann cells–originating tumors—may develop in many locations. However, primary schwannomas arising within lymph nodes are extremely rare, with only a few cases described to this date the English literature. For intranodal location, most of abdominal cavity. In these cases, clinicians may consider and check for familial disorders, such as neurofibromatosis type 2 (NF2) schwannomatosis also called 3. Schwannomas benign neoplasms. Histologically, differential...
Solitary bone plasmacytomas are part of a wide range monoclonal neoplasms that share common progenitor in the B lymphocyte lineage. In their particular case, single lesion is found, most frequently on axial skeleton, having evidence no other osteolytic lesions or systemic involvement. Diagnosis can sometimes prove to be difficult as they rare tumors, occurring 3 5% (up 10% some series) patients with plasma cell neoplasms, important considerations regarding differential diagnosis. We report...
Chronic kidney disease (CKD) commonly evolves with disturbances in mineral and bone metabolism, currently defined as CKD-MBD. Management strategies have progressed over the years, but our knowledge regarding evaluation treatment is still sparse. Herein, we describe a rare case of hemodialysis patient apparently fairly controlled hyperparathyroidism (HPTH), who developed multiple symptomatic brown tumors involving scull, mandible, vertebrae, pelvis, metacarpus. Parathyroidectomy allowed...
Biological therapies, including anti-TNF agents, are important in the treatment of various chronic inflammatory diseases, psoriasis, rheumatoid arthritis or bowel disease. The increased use these drugs translates into an increasing awareness its adverse effects, which include malignancy. In this paper, we describe case a 28-year-old woman who developed spitzoid melanocytic tumor after starting infliximab therapy for ulcerative colitis. evidence causality between and proliferations is still...
Purpose: To report a rare case of lacrimal gland carcinoma ex pleomorphic adenoma (Ca PA) with chronic B-cell lymphocytic leukemia (B-CLL) infiltration in patient without previous diagnosis B-CLL. Patient and methods: We 66-year-old woman who presented recent worsening long-standing right eye proptosis. Sequential orbital computed tomography imaging was performed over the course 2 years, biopsy specimens were analyzed. Results: Initial scans revealed lesion stable dimensions for more than 1...
A 68 year-old female presents with an ulcerated mass of the 5th digit, rapid growth during previous month to surgery. The was excised and covered a 4th dorsal metacarpal artery perforator flap. histologic analysis compatible diagnosis fibro-osseous pseudotumor digit.
Schwannoma is a benign encapsulated nerve sheath tumor composed of Schwann cells, that may arise anywhere along the course nerve. Cutaneous schwannomas, associated with peripheral nerves, usually present as slow-growing well-circumscribed nodule, localized in dermis or subcutaneous tissue. They are generally asymptomatic; however, they become painful by nervous compression. Since clinical signs non-specific, histology required for definitive diagnosis. Herein, we case solitary cutaneous...
Parathyroid carcinoma is an extremely rare cause of hyperparathyroidism. Histologic diagnosis may be challenging. DAB, male aged 66 was submitted to subtotal gastrectomy because a localized gastric adenocarcinoma (intestinal type). A mild primary hyperparathyroidism simultaneously found. Calcium oxalate nephrolithiasis diagnosed 16 years before. Sonography revealed nodular lesion in the right lower thyroid pole, while NMR showed at left pole. The sestamibi scan found late image hyperfixation...
Parathyroid carcinoma is an extremely rare cause of hyperparathyroidism. Histologic diagnosis may be challenging. DAB, male aged 66 was submitted to subtotal gastrectomy because a localized gastric adenocarcinoma (intestinal type). A mild primary hyperparathyroidism simultaneously found. Calcium oxalate nephrolithiasis diagnosed 16 years before. Sonography revealed nodular lesion in the right lower thyroid pole, while NMR showed at left pole. The sestamibi scan found late image hyperfixation...
Abstract Purpose: Trouillas’ clinicopathological classification is a five-tiered grading system designed to predict recurrence/progression in patients with pituitary adenomas (PAs). We aimed study its usefulness predicting PAs that will have challenging disease course and may require more often complex multimodal multiple therapeutic approaches. Methods: Retrospective analysis of 129 operated our institution between 2001 2020 (84 non-clinically functioning PAs, 32 acromegaly, 9 Cushing’s...
Disclosure: J. Rocha: None. R. Moiteiro da Cruz: M. Alexandre: A. Gomes: D. López-Presa: M.J. Bugalho:
Abstract Disclosure: C.R. Peixe: None. D. López-Presa: M. Bugalho: P. Marques: Introduction: Giant prolactinomas are rare, accounting for only 2–3% of all prolactinomas. Although benign, several challenges may emerge at diagnosis and during their management. Case: A 38-yr man was incidentally diagnosed with a large skull base tumor on CT-scan undertaken due to head trauma. MRI showed 55x33mm mass, involving the clivus sellar/parasellar regions, bilateral cavernous sinus invasion. chordoma...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)