A5022336963- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Viral-associated cancers and disorders
- Thyroid Cancer Diagnosis and Treatment
- Vascular Malformations and Hemangiomas
- Infective Endocarditis Diagnosis and Management
- Infectious Diseases and Tuberculosis
- Thyroid Disorders and Treatments
- HER2/EGFR in Cancer Research
- Advanced Glycation End Products research
- Neuroblastoma Research and Treatments
- IgG4-Related and Inflammatory Diseases
- Streptococcal Infections and Treatments
- Esophageal Cancer Research and Treatment
- Lung Cancer Research Studies
- Otolaryngology and Infectious Diseases
- Vascular Tumors and Angiosarcomas
- Cancer-related molecular mechanisms research
- Lymphadenopathy Diagnosis and Analysis
- Gastrointestinal disorders and treatments
- Thyroid and Parathyroid Surgery
- Chemokine receptors and signaling
- S100 Proteins and Annexins
Shikoku Cancer Center
2014-2019
Okayama University
2012-2015
Maizuru Municipal Hospital
1998
In tongue squamous cell carcinoma (SCC), high levels of regulatory T-cell (Treg) infiltration in tumor nests are observed the cases with poor prognosis.The role Tregs head and neck cancers remains unclear. The aim this study was to observe distribution different stages SCC estimate effects on prognosis.Thirty-four were examined immunohistochemically for CD4, CD8, Forkhead box P3 (Foxp3). Immunoreactive cells counted cancer stroma nest regions, relationships between numbers disease-free...
Conclusion: The characteristic ultrasound appearance of mucosa-associated lymphoid tissue (MALT) lymphoma the head and neck provides diagnostic information regarding masses or swellings in region. Objectives: There are only a few reports about features malignant (ML) neck. We have noticed that appearances cases with MALT resembled each other even when images like computed tomography were absolutely different. objective this study was to delineate reliability Methods: examinations 30 patients...
Background Few studies have investigated the prognostic factors for nasal natural killer (NK)/T‐cell lymphoma. Methods This was a retrospective multicenter clinical study. The records of 36 patients with NK/T‐cell lymphoma who had been first treated between 1996 and 2011 were collected from 12 hospitals. Results High serum levels C‐reactive protein (≥1.0 mg/dL), lactate dehydrogenase (≥350 IU/L), soluble interleukin‐2 receptor (sIL‐2R; ≥600 U/mL) associated worse prognosis. A score devised...
We present a case of 67-year-old Japanese man with serious oropharyngeal ulceration that at first seemed to be destructive malignant lymphoma or carcinoma. suspected methotrexate (MTX)-associated lymphoproliferative disorder (LPD) induced by MTX treatment for rheumatoid arthritis (RA). About 3 weeks after simple discontinuation MTX, complete regression the disease was observed, confirming our diagnosis.
Abstract Objective: This study examined whether the occurrence of late neck metastasis in early tongue squamous cell carcinoma can be predicted by evaluating HMGB1 (high mobility group box 1) expression primary lesion. Methods: A case–control was conducted. The cases comprised 10 patients with metastasis. controls consisted 16 without recurrence. All were immunohistochemically for protein expression. odds ratio relation to estimated. Results: Results dichotomised into positive staining...
Sonography-guided cutting needle biopsy for the diagnosis of malignant lymphoma has recently come into wide use. However, surgery is sometimes unavoidable lymphoma, particularly low-grade such as extranodal marginal zone B-cell mucosa-associated lymphoid tissue, because offers limited diagnostic accuracy lymphoma. Of course, unnecessary invasive procedures like open should be avoided wherever possible, given cosmetic problems and burden on patient. We tried to diagnose using combination...
Conclusion: Cutting needle biopsy (CNB) combined with immunohistochemical study of myeloperoxidase (MPO) is a useful minimally invasive diagnostic procedure for histiocytic necrotizing lymphadenitis (HNL). Objectives: HNL mainly diagnosed by pathological findings open surgical (OSB) specimens. Recently the appearance anti-MPO positive histiocytes has been reported as highly specific diagnosis HNL. Considering cosmetic impact and burden on patients, we performed CNB MPO Few studies have...
The primary laryngeal atypical carcinoid is relatively rare, and the tumor combined with other histologic types including squamous cell carcinoma extremely rare. We experienced a case which was complicated carcinoma. A 79 years old man complaining of sputum admitted to Hiroshima City Hospital. seen in over right glottis vocal fold fixed. Squamous diagnosed based on biopsy harvested under laryngoscopy. Imaging studies (CT, MRI) were done. aryepiglottic fold, one swollen lymph node found level...
Head and neck angiosarcoma (AS) is extremely rare. We report the fourth case of radiation-induced laryngeal AS. The patient a 73-year-old man with past medical history radiation treatment for hypopharyngeal cancer. Laryngoscopy revealed huge mass necrotic lesion in larynx pharynx. Biopsy showed performed radical resection. pathological diagnosis was 32 months after surgery, died by local relapse. spent over 2 years without consider surgery as first-line
セツキシマブは，EGFRを標的としたモノクローナル抗体で，現在，頭頸部癌における唯一の分子標的薬である。米国のNCCNガイドラインでは，局所進行頭頸部扁平上皮癌治療の選択肢として，セツキシマブ併用放射線療法が記載されている。当院では，現在まで頭頸部扁平上皮癌11例に適用した。内訳は，中咽頭癌6例，下咽頭癌2例，喉頭癌3例。Stage II4例，III3例，IVA4例。男性10例，女性1例で，年齢は49～81歳（中央値63歳），PSは全例0であった。ほぼ全例で，Grade3の放射線性皮膚炎・口腔咽頭粘膜炎が生じたが，Grade4の有害事象は生じず，全例で治療完遂できた。治療終了12週間後の評価は，全体でCR9例，PR2例であり，Stage III/IVではCR5例，PR2例であった。今後，症例数を積み重ね，長期成績も含めた検討が必要であると考えられた。
2015年米国甲状腺学会（ATA）ガイドライン改訂に伴い，当院における甲状腺髄様癌（MTC）治療との比較を行った。2000年～2016年の間に当院で診断・治療されたMTCは5例（男性2名，女性3名）で，3例が術前細胞診でMTCを疑われた。RET遺伝子検査は1例術前，3例術後に施行し，散発性3例，MEN2A1例であった（1例拒否）。MTCを疑う場合，ATAガイドラインでは全摘術を推奨している。一方術後にMTCと判明した散発性症例に関して，補完全摘は必ずしも推奨されない。当院では散発性2例に非全摘術を施行し，追加治療は施行していない。今後の方針として，術前遺伝学的検査の徹底をすること，治療は甲状腺全摘術を原則（症例により非全摘も考慮）とすることを確認した。
Objective: Hypothyroidism is a noteworthy complication after hemithyroidectomy, and its reported frequency varies widely in the range of 22%–56%. If we can predict thyroid function it would help us to explain risk post-operative hypothyroidism patient.
Objective: To evaluate the post-operative speech and swallowing functions of tongue cancer patients who underwent subtotal glossectomy free-flap reconstruction.