A5101882514- Salivary Gland Disorders and Functions
- Systemic Sclerosis and Related Diseases
- Pluripotent Stem Cells Research
- Pulmonary Hypertension Research and Treatments
- Diabetes and associated disorders
- Salivary Gland Tumors Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- CRISPR and Genetic Engineering
- Dialysis and Renal Disease Management
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Heart Failure Treatment and Management
- Renal and related cancers
- Assembly Line Balancing Optimization
- Telomeres, Telomerase, and Senescence
- Inflammatory Myopathies and Dermatomyositis
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Pediatric Hepatobiliary Diseases and Treatments
- Vascular Anomalies and Treatments
- Phonocardiography and Auscultation Techniques
- Cardiac pacing and defibrillation studies
- Spondyloarthritis Studies and Treatments
- Hemophilia Treatment and Research
- Liver Disease Diagnosis and Treatment
- Ear Surgery and Otitis Media
National Cheng Kung University Hospital
2003-2024
Kaohsiung Veterans General Hospital
2022-2024
Chung Shan Medical University Hospital
2010-2024
National Cheng Kung University
2024
Fooyin University
2023
Ministry of Health and Welfare
2023
Genomics Research Center, Academia Sinica
2019-2022
Taipei Tzu Chi Hospital
2021
China Medical University
2020
Taipei Medical University Hospital
2019
To estimate and compare the burdens of opportunistic infections herpes zoster in real-world practice among patients with various systemic rheumatic diseases.This 13-year cohort study used national health insurance data to incidence rates (IRs) nine five diseases. The analyses were stratified according follow-up duration using Poisson regression, Cox models risk first infection.During 2000-2013, we identified 76,966 who had polymyositis/dermatomyositis (PM/DM, 2270 cases), lupus erythematosus...
Self‐management intervention is a good method to improve self‐care ability, as such, promote quality of life. However, the research focused on self‐management in heart failure patients T aiwan very limited. Therefore, purposes this study were test effectiveness with Taiwan and examine relationship between ability A quasi‐experimental design was used convenience sampling. Of 82 subjects participating study, 40 them chose join experimental (self‐management plus usual care) 42 control (usual...
No population-based study has investigated the cumulative incidence of pulmonary arterial hypertension (PAH) in patients with newly diagnosed systemic lupus erythematosus (SLE) or survival impact PAH this population. We used a nationwide database Taiwan and enrolled incident SLE between January 1, 2000, December 31, 2013. The these were estimated by Kaplan-Meier method. Potential predictors development determined using Cox proportional hazards regression model. Of 15,783 patients, 336...
Objective. Bidirectional relationships between some autoimmune diseases and non-Hodgkin lymphoma (NHL) may exist. We conducted this nationwide population-based study in Taiwan to investigate whether there is a bidirectional relationship primary Sjögren syndrome (pSS) NHL. Methods. Using the National Health Insurance Research Database of Taiwan, we identified 15,636 patients with new-onset pSS without previous cancer 25,074 NHL as 2 non-overlapping cohorts from 1998 2012, followed them until...
To evaluate the nasal mucosal changes in rhinitis medicamentosa (RM), especially those related to goblet cells and subepithelial glands, we studied specimens of inferior turbinate mucosa from 8 patients with RM, chronic hypertrophic (CHR), 5 normal mucosa. All were assessed by electron microscopy immunohistochemical study. Under a scanning microscope, hyperplasia was most prominent RM group, an increased number gland openings evident CHR groups. In addition, immunoreactivity epidermal growth...
An understanding of the contribution daily physical activity and functional status to quality life in patients with heart failure has potential enable achieve better outcomes. Nevertheless, research that examines relationship between these 3 variables Taiwan is lacking. Therefore, purpose this study was close gap by exploring among activity, status, population.This used a descriptive, cross-sectional, correlational design. A convenience sample 108 recruited, from November 2009 September...
Patients with rheumatoid arthritis are prone to developing diabetes, which may lead various sequelae and even cardiovascular diseases, the most common cause of death in such patients. Previous research has shown that some treatments help prevent development diabetes. This study aimed investigate whether patients using disease-modifying anti-rheumatic drugs (DMARDs) have different levels risk for diabetes analyse other factors diabetes.This cohort used data from Chang Gung Research Database....
Abstract Background Rheumatoid arthritis (RA) is a major risk factor for osteoporosis/osteoporotic fractures. We aimed to elucidate the role of treatment choices among Methodology utilized Chang‐Gung Research Database assess risks fractures independently treated RA patients, using retrospective time‐to‐event outcomes analysis. Results A total 3509 patients with mean 63.1 ± 8.6 years were analyzed. Among all, 1300 (37%) diagnosed newly osteoporosis. The crude incidence osteoporosis was...
Abstract Background Primary Sjögren’s syndrome (pSS) is associated with dental caries. Pilocarpine, a salivary stimulant, can improve the amount and flow rate of saliva in patients pSS. This study aimed to assess whether risk caries decreases use pilocarpine Methods For this prospective cohort study, we identified pSS from catastrophic illnesses registry National Health Insurance Research Database Taiwan between 2009 2013. We divided participants into non-user groups based on prescriptions...
Abstract Deciphering signaling mechanisms critical for the extended pluripotent stem cell (EPSC) state and primed pluripotency is necessary understanding embryonic development. Here, a membrane protein, podocalyxin‐like protein 1 (PODXL) as being essential pluripotency, identified. Alteration of PODXL expression levels affects self‐renewal, c‐MYC telomerase, induced (iPSC) EPSC colony formation. first reported to regulate de novo cholesterol biosynthesis, human cells (hPSCs) are more...
To determine the risk and time trends of heart failure (HF) leading to hospitalization in individuals newly diagnosed as having polymyositis/dermatomyositis (PM/DM) relative non-PM/DM controls at general population level.A retrospective cohort study was conducted using data from a nationwide insurance database Taiwan. Patients with incident PM/DM without history HF were selected between 2000 2013. Unmatched propensity score-matched cohorts established separately. A multivariable Cox...
Objective Metformin has been linked to anti-proliferative and anti-inflammatory mechanisms. In this study, we aimed examine the long-term impact of metformin on mortality organ damage in patients with autoimmune diseases type 2 diabetes mellitus (T2DM). Methods We conducted a cohort study using National Health Insurance Research Database Taiwan between 1997 2013. Based other anti-diabetic agent prescriptions, categorized all into either group (metformin administration for at least 28 days)...
The long-term renal outcome in patients with primary Sjögren's syndrome (pSS) remains uncertain. We aimed to determine the absolute incidence and relative risk of chronic kidney disease (CKD) end-stage (ESRD) pSS at general population level. performed a retrospective cohort study using national health insurance database Taiwan from 2000 2013. calculated cumulative CKD ESRD our age-, sex- entry time-matched control cohorts. Cox regression analyses were used estimate adjusted hazard ratios...
We reveal by high-throughput screening that activating transcription factor 1 (ATF1) is a novel pluripotent regulator in human embryonic stem cells (hESCs). The knockdown of ATF1 expression significantly up-regulated neuroectoderm (NE) genes but not mesoderm, endoderm, and trophectoderm genes. Of note, down-regulation or knockout with short hairpin RNA (shRNA), small interfering (siRNA), clustered regularly interspaced palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) was...
A 66-year-old man presented with right upper quadrant pain and progressive dyspnea for 2 days. He had history of chronic obstructive pulmonary disease kidney disease. On admission, he was febrile sinus tachycardia. Laboratory findings showed an elevated white blood cell count 18.01 × 109/L 92.1 % neutrophils. Liver function tests revealed normal alanine aminotransferase (14 U/L [3 – 37 U/L]), total bilirubin (0.6 mg/dL [0 1.0 mg/dL]), alkaline phosphatase (157 [39 120 U/L]). Ultrasonography...
Due to the characteristics of small-volume-large-variety production in aircraft industry, determining how intelligently take men, machines, materials, methods, and environments into account is critical for production, posing challenge scheduling job shop. The existing system slow adapt when requirements change and, most importantly, consider current situation line. In this study, we apply Tabu search algorithm resolve problem. This method swaps manufacturing orders with consideration due...
Primary myocardial involvement is an important cause of death in systemic sclerosis (SSc). Subclinical diastolic/systolic heart dysfunction recognized; however, whether this indicates a subsequent increased risk clinically overt failure (HF) remains largely unknown. We aimed to investigate the HF large, unselected SSc cohort.This matched, retrospective cohort study was conducted using nationwide insurance database Taiwan. Incident patients with no history were identified, and non-SSc...
Background: Pulmonary arterial hypertension (PAH) is a life-threatening disease with different etiologies and outcomes. We aimed to explore differences in clinical features outcomes of idiopathic PAH (iPAH) connective tissue disease-related (CTD-PAH) Taiwanese patients determine risk factors for mortality. Methods: retrospectively reviewed the medical records right-sided heart catheterization-diagnosed between January 2005 December 2015. The iPAH (n = 31) CTD-PAH 14) were enrolled followed...
Abstract Background A variety of chronic inflammatory diseases are linked to ischemic heart disease (IHD); however, this association is less well studied in patients with Behçet’s syndrome (BS). The primary objective study was examine the impact BS on risk IHD. secondary estimate long-term mortality BS. Methods Using a retrospective cohort design based Taiwan National Health Insurance Database, diagnosed between 2000 and 2013, without prior history IHD, were compared non-BS individuals....
We report on a consanguineous Egyptian family focusing 15-year-old girl exhibiting features of Hoyeraal–Hreidarsson syndrome (HHS). Genetic analysis revealed novel new homozygous acceptor splice-site variant in the PARN gene, causing significant telomere shortening. The expands genetic landscape biology disorders.
Chronic kidney disease (CKD) is prevalent among the elderly. However, little known about how clinical course of CKD vary with age. The purpose this study was to examine impact aging on risk end-stage (ESKD) in patients moderate advanced CKD.A total 454 stages 3-5 were prospectively followed for a median 5.1 years. primary outcome ESKD needing chronic dialysis therapy or preemptive transplantation. secondary composite all-cause mortality.The mean age 65 ± 13 65.4% men, 44.9% had diabetes...
Mounting evidence has demonstrated that various chronic inflammatory diseases are associated with incident heart failure (HF). However, there is scarce about the association between primary Sjögren's syndrome (pSS) and HF. We aimed to explore this using a nationwide database in Taiwan.We selected patients pSS no history of Using propensity score matching based on age, sex, cohort entry time, comorbidities, concomitant medications, cohorts without (as controls) were created 1:1 ratio groups...