A5026752612- Substance Abuse Treatment and Outcomes
- Racial and Ethnic Identity Research
- Homelessness and Social Issues
- Alcohol Consumption and Health Effects
- Child and Adolescent Psychosocial and Emotional Development
- Smoking Behavior and Cessation
- School Health and Nursing Education
- Migration, Health and Trauma
- Health Policy Implementation Science
- Cannabis and Cannabinoid Research
- Community Health and Development
- Mental Health Treatment and Access
- Emergency and Acute Care Studies
- Behavioral Health and Interventions
- Opioid Use Disorder Treatment
- Platelet Disorders and Treatments
- Physical Activity and Health
- HIV, Drug Use, Sexual Risk
- Vascular Procedures and Complications
- Child Abuse and Trauma
- Health and Lifestyle Studies
- Cardiac Arrest and Resuscitation
- Resilience and Mental Health
- Family and Patient Care in Intensive Care Units
- Suicide and Self-Harm Studies
Boston University
2018-2025
Boston Medical Center
2024
Beth Israel Deaconess Medical Center
2024
Harvard University
2024
University of Nottingham
2019-2023
Center for Innovation
2020-2023
Denver Health Medical Center
2023
Health and Hospital Corporation
2023
Brooke Army Medical Center
2022-2023
University of Colorado Denver
2023
Abstract The CRISPR–Cas9 system provides a versatile toolkit for genome engineering that can introduce various DNA lesions at specific genomic locations. However, better understanding of the nature these and repair pathways engaged is critical to realizing full potential this technology. Here we characterize different arising from each Cas9 variant resulting pathway engagement. We demonstrate presence polarity overhang structure determinant double-strand break choice. Similarly, single nicks...
Objective Emergency Departments (EDs) offer an opportunity to improve the care of patients with at-risk and dependent drinking by teaching staff screen, perform brief intervention refer treatment (SBIRT). We describe here implementation at 14 Academic EDs a structured SBIRT curriculum determine if this learning experience improves provider beliefs practices. Methods ED faculty, residents, nurses, physician extenders, social workers, Medical Technicians (EMTs) were surveyed prior...
A randomized clinical trial of culturally adapted and unadapted motivational interviewing to reduce drinking related problems among heavy Latinos assessed 57 participants at baseline 2 (86% retention) 6 months (84% after treatment. Significant decreases across both treatments were found in days per month consequences (p < .001), with greater reductions for = .009) continuing months. Findings provide preliminary support the value cultural adaptation enhance efficacy Latino drinkers.
Adults often develop chronic immune thrombocytopenia (ITP) for which treatment order is uncertain. Rituximab and three cycles of dexamethasone (4R + 3Dex) improve responses short-term disease control but long-term outcome not known. In adults with ITP treated 4R 3D, we sought associated prognostic variables. Forty-nine at Weill-Cornell received 3Dex. Their clinical characteristics were reviewed. Duration was median time to failure; Kaplan-Meier estimates developed. Vbeta Tcell receptor...
Given the significant syndemic of HIV and substance use in U.S., this study sought to examine patterns (consistent user, former recent adopter, abstainers) identify sociodemographic disparities among people with (PWH). Using 2015–2019 National Survey on Drug Use Health data (N = 212,411), we estimated prevalence rates conducted multinomial logistic regression assess associations between status (1) (2) factors. Results show PWH have higher consistent a range substances, including inhalants,...
Although the need for cultural adaptations is often noted in addiction research, there are few templates to guide process. The rationale a social contextual framework culturally adapt motivational interviewing an immigrant heavy drinking Latino population U.S. Northeast presented. aim of pilot study was obtain data on acceptability this approach. Participant responses adaptation were examined qualitatively and quantitatively preliminary study. Participants recruited from community met...
Brief motivational interventions (BMIs) are usually effective for reducing alcohol use and consequences in primary care settings. We examined readiness to change drinking as a mediator of the effects BMI on alcohol-related consequences. Participants were randomized into three conditions: (a) standard plus assessment (SC), (b) SC (BI), (c) BI booster session (BIB). At 12-month follow-up BIB patients had significantly reduced more than patients. Patients receiving or maintained higher scores 3...
This study investigates the relationship between level of acculturation and stress extent to which each predicts problems related drinking. Hispanics who met criteria for hazardous drinking completed measures acculturation, stress, problems. Sequential multiple regression was used determine whether levels self-reported predicted concurrent alcohol after controlling predictive value level. Acculturation accounted a significant variance in problems, while adjusting income, education. Choosing...
Epidemiologic data suggest men often experience excessive morbidity and early mortality, possibly compromising family community health over the lifespan. Moreover, negative financial/economic consequences affected by poor male outcomes also has been of great concern in United States abroad. Early consistent access to preventative care may improve outcomes; however, are far less likely these services. The purpose this study was understand what factors preclude from accessing care. We surveyed...
This randomized controlled trial (Clinicaltrials.gov NCT [01996280]) compared the efficacy of a brief motivational interview (MI) adapted to address social stressors and cultural influences (culturally MI [CAMI]) standard for heavy-drinking Latinxs. CAMI was hypothesized reduce heavy drinking days frequency alcohol-related consequences more than MI. Moderators treatment effect were explored.
Abstract Clostridioides difficile ( C. ) is the predominant causative agent of nosocomial diarrhea worldwide. Infection with occurs due to secretion large glycosylating toxin proteins, which can lead toxic megacolon or mortality in susceptible hosts. A critical aspect difficile's biology its ability persist asymptomatically within human host. Individuals harboring asymptomatic colonization experiencing a single episode infection (CDI) without recurrence exhibit heightened immune responses...
Simultaneous alcohol and marijuana (SAM) use exposes college students to a myriad of adverse consequences. However, there is no recent nationally representative study on SAM among in the United States (US). To provide an update literature, present aimed examine trends, prevalence, correlates US between 2006 2019, using data. We used data from 2006-2019 National Survey Drug Use Health (NSDUH) analytic sample was limited 55,669 full-time student respondents (ages 18-22). Using logistic...
The severity of heavy drinking among Asian Americans has often been dismissed because relatively low rates compared to other racial/ethnic groups.However, higher depression and suicide their association alcohol use suggest serious detrimental effects Americans.Gender differences in have documented immigrant based ethnic minorities, little is known this pattern for Americans.The purpose the present study was examine gender drinking, poor mental health, substance a national sample (N = 581)...
Objectives Few studies have explored predictors of entry into and retention in buprenorphine treatment following linkage from an acute medical hospitalization. Methods This secondary analysis a completed clinical trial focuses on medically hospitalized, opioid‐dependent patients ( n = 72) who were randomized to intervention including induction dose stabilization during hospitalization followed by post‐discharge transition office‐based (OBOT). Predictors included demographics, days prior...