A5101847937- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- Bee Products Chemical Analysis
- Neural Networks and Applications
- Circadian rhythm and melatonin
- Aortic aneurysm repair treatments
- Monoclonal and Polyclonal Antibodies Research
- Rheumatoid Arthritis Research and Therapies
- Seaweed-derived Bioactive Compounds
- Advancements in Transdermal Drug Delivery
- Academic integrity and plagiarism
- Neuroinflammation and Neurodegeneration Mechanisms
- Orthopedic Infections and Treatments
- Cancer, Hypoxia, and Metabolism
- Coronary Interventions and Diagnostics
- Bone and Joint Diseases
- T-cell and B-cell Immunology
- Cardiac and Coronary Surgery Techniques
- Optical Coherence Tomography Applications
- Cancer therapeutics and mechanisms
- Cancer Cells and Metastasis
- Radiopharmaceutical Chemistry and Applications
- Random lasers and scattering media
Changzhou University
2024
Nanjing Agricultural University
2019-2024
Shandong University
2024
Tianjin University
2024
Jilin University
2019-2022
Nanjing Normal University
2020
Cyclophosphamide (CY), extensively used as an anti-cancer agent, could cause diverse side effects, such immunosuppression and intestinal barrier damage.
Background Sunitinib is approved for the treatment of metastatic renal cell carcinoma (mRCC), imatinib-resistant gastrointestinal stromal tumors (GIST), and advanced pancreatic neuroendocrine (PNET). This study aims to investigate safety profiles sunitinib through data mining US Food Drug Administration Adverse Event Reporting System (FAERS). Methods The individual case reports (ICSRs) on from 2006 Q1 2024 were collected ASCII packages in After standardizing data, a variety...
In the treatment of coronary artery disease (CAD), use stent implantation often leads to clinical complications such as restenosis, delayed endothelial healing, and thrombosis. Here, we develop a double drug sustained-release coating for surface by grafting heparin/NONOate nanoparticles (Hep/NONOates). The Hep/NONOates modification were characterized X-ray photoelectron spectroscopy, attenuated total reflection Fourier-transform infrared static water contact angle, scanning electron...
A series of thiophene derivatives were synthesized by functionalization 2,3-fused scaffolds. Their cytotoxicity was assessed against HeLa and Hep G2 cells. Compound 480 identified as a promising candidate because its low IC50 in (12.61 μg/mL) (33.42 The drug loaded into folic acid (FA)-coated nanoparticles (NPs) to address poor water solubility improve selectivity for cancer shown induce apoptosis changes mitochondrial membrane potential (ΔΨm) the reactive oxygen species level. Furthermore,...
Docetaxel (DTX) is a semi-synthetic analogue of paclitaxel which has attracted extensive attention in the treatment cancer. However, current clinically used DTX formulations display low tumor targeting ability, leading to unsatisfactory therapeutic outcomes with adverse effects, poses significant challenges clinical application. In this study, three galactosamine (Gal) and docetaxel conjugates different linkers were synthesized, namely DTX-(suc-Gal)
Vaccines are an effective intervention for preventing infectious diseases. Currently many vaccine strategies designed to improve efficacy by controlling antigen release, typically involving various approaches at the injection site. Yet, intracellular slow-release of antigens in vaccines still unexplored. Our study showed that degradation dendritic cells and slowing their transport from early endosomes lysosomes markedly enhances both antigen-specific T-cell immune responses germinal center B...
Poor selectivity to tumor cells is a major drawback in the clinical application of antitumor drug docetaxel (DTX). Peptide-drug conjugates (PDCs) constructed by modifying drugs with peptide ligands that have high affinity certain overexpressed receptors are increasingly assessed for their possibility tumor-selective delivery. In present research, DTX condensed 3-(pyridin-2-yldisulfanyl) propanoic acid via ester bond obtain intermediate Py-SS-DTX. Two GSS-DTX and RGDC-SS-DTX were obtained...
Overlapped multi-focus light sheet (MF-LS) along beam propagation microscope has generated significant interest due to its reportedly superior axial resolving power when compared conventional Gaussian (GLS) systems. By axially overlapped multiple sheets in the illumination path, it would weld combined field of view (FOV) and be wider than stationary counterparts. However, effect diffractive energy entering focal space desired beam, impacting optical sectioning capabilities system not been...
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