Alparslan Kılıç

ORCID: 0000-0002-2308-197X
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About
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Research Areas
  • Acute Myocardial Infarction Research
  • Cardiovascular Function and Risk Factors
  • Acute Kidney Injury Research
  • Inflammatory Biomarkers in Disease Prognosis
  • Cardiac Imaging and Diagnostics
  • Cardiovascular Health and Disease Prevention
  • Chronic Kidney Disease and Diabetes
  • Blood Pressure and Hypertension Studies
  • Antiplatelet Therapy and Cardiovascular Diseases
  • Atrial Fibrillation Management and Outcomes
  • Lipoproteins and Cardiovascular Health
  • Sepsis Diagnosis and Treatment
  • Cardiac Arrhythmias and Treatments
  • Hyperglycemia and glycemic control in critically ill and hospitalized patients
  • Cardiovascular Disease and Adiposity
  • Renal and Vascular Pathologies
  • Liver Disease Diagnosis and Treatment
  • Adipokines, Inflammation, and Metabolic Diseases
  • Trauma, Hemostasis, Coagulopathy, Resuscitation
  • Cardiac and Coronary Surgery Techniques
  • Respiratory and Cough-Related Research
  • Cardiovascular Effects of Exercise
  • Cardiovascular and exercise physiology
  • Cardiac Arrest and Resuscitation
  • Diabetes, Cardiovascular Risks, and Lipoproteins

Koç University
2019-2023

UPMC Health System
2021

Ufuk University
2013-2020

Ministry of Health
2015-2019

Ankara (Czechia)
2018

Education Training And Research
2015

High SYNTAX score is a predictor of adverse cardiovascular events, including mortality, in acute coronary syndromes (ACSs). Decreased serum albumin (SA) concentration associated with an increased risk events. We aimed to investigate whether SA levels at admission are high and in-hospital mortality patients ACS. The study included 1303 ACS who underwent angiography (CA). were divided into 2 groups as (≥33) lower (≤32). Baseline significantly than (3.46 ± 0.42 mg/dL vs 3.97±0.37 mg/dL,...

10.1177/0003319715575220 article EN Angiology 2015-03-17

High sensitive C-reactive protein (hs-CRP) levels are associated with short- and long-term mortality in patients acute coronary syndrome (ACS). We investigated whether baseline hs-CRP burden of atherosclerosis assessed by SYNTAX score (SXScore).We enrolled 321 ACS who underwent angiography. The were divided into tertiles according to the SXScore: low SXScore (≤ 22), intermediate-high (≥ 23).Subjects tertile had higher serum compare (7.7 ± 3.4 mg/L versus 4.9 2.5 mg/L, P < 0.001). mean age...

10.1536/ihj.14-299 article EN International Heart Journal 2015-01-01

Background Recently, it has been shown that the lymphocyte-to-monocyte ratio (LMR) is a novel inflammatory marker. A decreased LMR associated significantly with high risk for vascular endpoints in patients peripheral arterial disease. We aimed to investigate whether on admission no-reflow after primary percutaneous coronary intervention (PCI) ST-elevation myocardial infarction (STEMI). Patients and methods total of 857 (mean age 58.9±13.1 years, 75.6% men), who were admitted our hospital...

10.1097/mca.0000000000000301 article EN Coronary Artery Disease 2015-09-04

Contrast-induced acute kidney injury (CI-AKI) is a major issue after percutaneous coronary intervention (PCI), especially in the setting of syndrome (ACS). associated with increased mortality and morbidity. Inflammation plays an important role pathophysiology CI-AKI. Procalcitonin (PCT) introduced as new marker inflammation. We sought to examine whether admission PCT levels predict development Patients (n = 814) were divided into 2 groups, namely, CI-AKI (-) (+). An increase serum creatinine...

10.1177/0003319715572218 article EN Angiology 2015-02-16

In-stent restenosis (ISR) is a common clinical problem in patients with coronary artery disease treated percutaneous intervention. Inflammatory process plays pivotal role the development of ISR. Both lymphocytes and monocytes are associated inflammatory status. Recently, it has been shown that lymphocyte-to-monocyte ratio (LMR) novel marker. We aimed to investigate association serum LMR levels ISR undergoing bare-metal stent (BMS) implantation. The study included 273 (aged 61 ± 11 years,...

10.1177/1076029615627340 article EN Clinical and Applied Thrombosis/Hemostasis 2016-01-13

Insulin resistance is one of the most important risk factors that accelerate atherosclerosis. The goal this study to investigate relationship between triglyceride glucose (TyG) index and functional vessel disease measured using pulse wave velocity (PWV), in a nondiabetic asymptomatic Turkish population. Nondiabetic, healthy patients (n = 1095) with no previous history coronary heart were enrolled. Functional was detected by measuring PWV. TyG calculated following equation: log [fasting...

10.1177/00033197211007719 article EN Angiology 2021-04-23

We investigated whether admission estimated glomerular filtration rate (eGFR) values are associated with no-reflow phenomenon in patients ST-segment elevation myocardial infarction (STEMI) treated primary percutaneous coronary intervention (pPCI). Patients (n = 673; 59 ± 13 years; 77.1% men) were stratified into 3 groups according to eGFR at admission: normal renal function (eGFR ≥ 90 mL/min/1.73 m 2 ), mild impairment 60-89 and moderate 30-59 ). No-reflow was defined as thrombolysis flow...

10.1177/0003319714546738 article EN Angiology 2014-08-13

Contrast-induced acute kidney injury (CI-AKI) is a common complication of diagnostic and therapeutic catheterizations, especially in the setting coronary syndrome (ACS). Fibrinogen well-known cardiovascular risk factor. We evaluated whether serum fibrinogen level associated independently with CI-AKI patients ACS who underwent percutaneous intervention (PCI).Patients (n=710, aged 61 ± 13, 69% men) were classified into two groups: non-CI-AKI. was defined as an increase at least 0.5 mg/dl or...

10.1097/mca.0000000000000295 article EN Coronary Artery Disease 2015-08-12

OBJECTIVES: Acute ST-segment elevation myocardial infarction patients presenting persistent no-flow after wire insertion have a lower survival rate despite successful mechanical intervention.The neutrophil-tolymphocyte ratio has been associated with increased mortality and worse clinical outcomes in infarction.We hypothesized that an elevated neutrophil-to-lymphocyte would also be Thrombolysis In Myocardial Infarction flow grade of 0 undergoing primary percutaneous coronary...

10.6061/clinics/2015(01)07 article EN cc-by-nc Clinics 2015-01-01

High Syntax score (SXscore) is associated with more serious disease and worse prognosis in patients acute coronary syndrome (ACS). Plasma fibrinogen levels are poor cardiovascular outcomes.To investigate the relation of admission intermediate-high SXscore ACS.A total 752 (61.6 ± 12.8 years, 67.3% men) ACS, who underwent urgent angiography (CAG) were enrolled. Laboratory data including high sensitivity C-reactive protein obtained before CAG. scores all calculated from baseline The divided...

10.5603/kp.a2015.0196 article EN Kardiologia Polska 2015-09-28

Aim: A lower lymphocyte count and a high monocyte give important clues about the prognosis of various cardiovascular diseases. We hypothesized that lymphocyte-to-monocyte ratio (LMR) was associated with saphenous vein graft disease (SVGD) in patients coronary artery bypass (CABG). Patients & methods: total 218 previous history CABG surgery, who underwent angiography due to stable angina symptoms, were investigated, retrospectively. Results: LMR levels significantly SVGD group. Multiple...

10.2217/bmm-2017-0079 article EN Biomarkers in Medicine 2017-10-01

Hyperhomocysteinemia is a known risk factor for acute coronary syndrome (ACS) and related with the severity of artery disease (CAD). Previous studies have used less quantifiable scoring systems assessing CAD. Therefore, we aimed to assess relationship between homocysteine levels SYNTAX score (SXscore), which currently more widely grade CAD.A total 503 patients adiagnosis ACS were examined angiographically SXscore. The divided into three groups according SXscore; Group 1 low SXscore (≤ 22), 2...

10.6515/acs.201811_34(6).20180528b article EN PubMed 2018-11-01

Arterial stiffness, known as a predictor of early vascular aging, was defined the main determinant cardiovascular mortality and morbidity. However, relationship between lipid profile increased arterial stiffness is not clear. The aim this study to investigate profiles in patients with aging syndrome.A total 1582 participants —504 (31.8%) were male mean age 52.8 ±14.2 years— included . Patients who applied hospital for various reasons had undergone 24-h blood pressure Holter monitoring study....

10.3906/sag-2008-165 article EN TURKISH JOURNAL OF MEDICAL SCIENCES 2020-12-28

The aim of this study was to assess whether changes in Cystatin C (CyC) after 48 h post contrast media exposure a reliable indicator acute kidney injury and the validity risk scoring tool for contrast-induced (CI-AKI).We enrolled 121 patients whom diagnostic coronary angiography were planned. score CI-AKI calculated serum creatinine (sCr) CyC measured before angiography. sCr based AKI as 25% increase from baseline within exposure.Mean concentrations 0.88 ± 0.27 mg/dL 0.79 0.22 mg/dL,...

10.4103/0022-3859.132317 article EN Journal of Postgraduate Medicine 2014-01-01

Objective: Circadian blood pressure (CBP) abnormalities are well-known risk factors for many diseases such as cardiovascular, cerebrovascular, and chronic kidney disease. The object of this study was to evaluate the relationship between in CBP rhythm target organ damage (TOD) normotensive non-dipper (non-DP) subjects.Methods: 24-h ambulatory BP monitoring (ABPM) echocardiography were performed urinary albumin excretion (UAE) measured 127 dipper (DP) (42 males, 85 females) 337 (89 248 non-DP...

10.1080/10641963.2019.1619757 article EN Clinical and Experimental Hypertension 2019-05-23

The no-reflow phenomenon is associated with adverse outcomes in patients acute ST-elevation myocardial infarction (STEMI) treated by a primary percutaneous coronary intervention (PPCI). Procalcitonin (PCT) marker of systemic inflammatory states and an elevated serum PCT concentration related to increased risk cardiovascular events. We aimed assess whether level at admission independent predictor STEMI PPCI.Between November 2012 December 2014, 501 consecutive who underwent PPCI within the...

10.1097/mca.0000000000000329 article EN Coronary Artery Disease 2015-12-24

Acute hyperglycemia and contrast-induced nephropathy (CIN) are frequently observed in non-ST elevation myocardial infarction (NSTEMI) patients undergoing percutaneous coronary intervention (PCI), both associated with an increased mortality rate. We investigated the possible association between acute CIN NSTEMI PCI.We retrospectively enrolled 281(149, 53% men) PCI. For each patient, plasma glucose levels were secreened at hospital admission. was defined as > 198 mg/dl. increase serum...

10.1097/xce.0000000000000187 article EN Cardiovascular Endocrinology & Metabolism 2020-03-01

Pulmonary complications are common in patients with liver cirrhosis. Devolopment of pulmonary hypertension (PH) is associated a poor prognosis these patients. arterial stiffness (PAS) considered an early sign vascular remodeling. The aim this study to investigate PAS and compare it right ventricular (RV) functions cirrhosis who scheduled for transplantation.The included 52 (mean age 51.01 ± 12.18 years, male gender 76.9%) were prepared transplantation 59 sex matched 51.28 13.63 62.7%)...

10.1002/jcu.23234 article EN Journal of Clinical Ultrasound 2022-05-21

It has been shown that psychological status is associated with the likelihood of atrial fibrillation (AF). Prolongation duration electromechanical delay (AEMD) known to be a precursor for AF development.Therefore, we aimed evaluate AEMD in patients anxiety disorder.In this prospective study, total 82 disorder and 80 healthy subjects were enrolled. Symptoms evaluated by using Hamilton Anxiety Rating Scale (HAM-A). P-wave dispersion (PWD) was measured on 12-lead electrocardiogram. Both intra-...

10.5603/kp.a2017.0038 article EN Kardiologia Polska 2017-03-10

Objectives Cardiac syndrome X (CSX) is a condition characterized by exercise-induced chest pain that occurs considering normal coronary angiogram. We aimed to investigate the total serum antioxidant capacity (TAC) and biventricular global functions using echocardiography in patients with CSX. Patients methods The study population included 55 typical anginal symptoms positive exercise stress test, or ischemia myocardial perfusion scintigraphy arteries detected angiographically, 49 healthy...

10.1097/mca.0000000000000293 article EN Coronary Artery Disease 2015-08-12

We evaluated if admissiontriglyceride-glucose index (TyG index) correlated with the anatomical synergy between percutaneous coronary intervention taxus and cardiac surgery (SYNTAX) score 2 in non-ST elevation myocardial infarction (NSTEMI), nondiabetic patients.SYNTAX (SSII) was retrospectively 260 patients hospitalized NSTEMI who underwent angiography. The TyG calculated using following equation: log [fasting triglycerides (mg/dl) × fasting glucose (mg/dl)/2]. stratified according to...

10.1097/xce.0000000000000277 article EN cc-by-nc-nd Cardiovascular Endocrinology & Metabolism 2023-01-05

Abstract Objectives In many diseases, immature platelet fraction (IPF%) is related to coagulopathy and poor outcome. This study aimed investigate the predictive value of IPF% for severity pneumonia in patients with Coronavirus Disease 2019 (COVID-19). Methods A total 154 COVID‐19 infections were included. The divided into two groups according (severe non-severe) regarding their oxygen demand. Results Given laboratory parameters, median was significantly higher severe group (11.9 vs. 3.9%,...

10.1515/tjb-2021-0070 article EN cc-by Turkish Journal of Biochemistry 2021-07-13

The CHA2DS2-VASC score, used for embolic risk stratification in atrial fibrillation, has been reported recently to predict adverse clinical outcomes patients with coronary artery disease. We investigated the correlation between score and contrast-induced nephropathy (CIN) non-ST elevation myocardial infarction (NSTEMI) who underwent percutaneous intervention (PCI).We retrospectively enrolled 363 (191; 52.6% men) NSTEMI undergoing PCI. CHA2 DS2-VASC was calculated each patient, study population...

10.1159/000501036 article EN cc-by-nc Kidney Diseases 2019-01-01

We evaluated if admission glycosylated hemoglobin (HbA1c) and fasting glucose levels are correlated with the severity of coronary artery disease (CAD) in non-ST-elevation myocardial infarction (NSTEMI), nondiabetic, patients. Coronary severity, according to anatomical synergy between percutaneous intervention (PCI) taxus cardiac surgery (SYNTAX) score 2 (SSII), was retrospectively 359 nondiabetic patients hospitalized NSTEMI who underwent angiography. Glucose intolerance assessed by serum...

10.1177/00033197211014678 article EN Angiology 2021-05-07
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