A5057850619- Mitochondrial Function and Pathology
- Neuroscience and Neuropharmacology Research
- CRISPR and Genetic Engineering
- Cancer, Lipids, and Metabolism
- Retinal Development and Disorders
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- Endoplasmic Reticulum Stress and Disease
- Ferroptosis and cancer prognosis
- ATP Synthase and ATPases Research
Helmholtz Zentrum München
2020-2024
Ludwig-Maximilians-Universität München
2020-2024
Urologische Klinik München
2024
University of Copenhagen
2019
Mitochondria account for essential cellular pathways, from ATP production to nucleotide metabolism, and their deficits lead neurological disorders contribute the onset of age-related diseases. Direct neuronal reprogramming aims at replacing neurons lost in such conditions, but very little is known about impact mitochondrial dysfunction on direct human cells. Here, we explore effects induced pluripotent stem cell (iPSC)-derived astrocytes carrying mutations NDUFS4 gene, important Complex I...
Astrocyte-to-neuron conversion is a promising avenue for neuronal replacement therapy. Neurons are particularly dependent on mitochondrial function, but how well mitochondria adapt to the new fate unknown. Here, we determined comprehensive proteome of cortical astrocytes and neurons, identifying about 150 significantly enriched proteins each cell type, including transporters, metabolic enzymes, cell-type-specific antioxidants. Monitoring their transition during reprogramming revealed late...