A5067763694- Diabetes Treatment and Management
- Diet and metabolism studies
- Pharmacology and Obesity Treatment
- Diabetes Management and Research
- Metabolism, Diabetes, and Cancer
- Regulation of Appetite and Obesity
- Nutrition, Genetics, and Disease
- Pancreatic function and diabetes
- Bariatric Surgery and Outcomes
- Biochemical Analysis and Sensing Techniques
- Dietary Effects on Health
- Diabetes and associated disorders
- Obesity, Physical Activity, Diet
- Eating Disorders and Behaviors
- Nutritional Studies and Diet
- Adipose Tissue and Metabolism
- Adrenal and Paraganglionic Tumors
- Hormonal Regulation and Hypertension
- Cancer Risks and Factors
- Pituitary Gland Disorders and Treatments
- Diabetes Management and Education
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diet, Metabolism, and Disease
- Menopause: Health Impacts and Treatments
- Celiac Disease Research and Management
Mayo Clinic in Arizona
2019-2024
Milken Institute
2024
George Washington University
2024
MedStar Health
2024
University of Michigan
2023-2024
Kings County Hospital Center
2024
State University of New York
2024
Carolina Institute for NanoMedicine
2024
Kaiser Permanente
2024
Jacksonville College
2023-2024
Importance No retrospective cohort study has assessed the effectiveness of semaglutide at doses used in randomized clinical trials to treat obesity (ie, 1.7 and 2.4 mg). Objective To weight loss outcomes associated with treatment for patients overweight or obesity. Design, Setting, Participants This study, conducted a referral center management, retrospectively collected data on use adults between January 1, 2021, March 15, 2022, follow-up up 6 months. A total 408 body mass index (BMI) 27...
Summary Objective To identify predictors of hypothalamic‐pituitary‐adrenal ( HPA ) axis recovery interval and severity glucocorticoid withdrawal symptoms GWS in patients undergoing adrenalectomy for corticotropin‐independent cortisol excess. Design This is a retrospective study with mild autonomous excess MACE ), moderate severe Cushing syndrome CS who developed adrenal insufficiency after unilateral between 1998 2017. Results Adrenalectomy was performed 81 (79% women, median age 52 years [...
No effective systemic treatment is available for patients with unresectable, recurrent, or metastatic mucoepidermoid carcinoma (MEC), the most common salivary gland malignancy. MEC frequently associated a t(11;19)(q14-21;p12-13) translocation that creates CRTC1-MAML2 fusion gene. The exhibited transforming activity in vitro; however, whether it serves as an oncogenic driver establishment and maintenance vivo remains unknown. Here, we show doxycycline-induced knockdown blocked growth of...
Abstract Objective To compare weight loss response and changes in cardiometabolic risk markers postmenopausal women using semaglutide with without menopause hormone therapy (HT) use. Methods Retrospective cohort study of treated for overweight or obesity ≥3 months. Endpoints: total body percentage (TBWL%) at 3, 6, 9, 12 months after initiation; achieving ≥5% ≥10% TBWL (glucose, blood pressure, lipids) Results There were 16 on HT 90 no-HT; mean age 56 ± 8 vs 59 yr, P = 0.2 BMI 36 5 39 kg/m 2...
Peptide YY(3-36) is a satiation hormone released postprandially into the bloodstream from L-endocrine cells in gut epithelia. In current report, we demonstrate PYY(3-36) also present murine as well human saliva. mice, salivary derives plasma and synthesized taste buds of tongue. Moreover, cognate receptor Y2R abundantly expressed basal layer progenitor tongue epithelia von Ebner's gland. The acute augmentation induced stronger demonstrated feeding behavioral studies. effect mediated through...
It has been hypothesized that the peripheral taste system may be modulated in context of an animal's metabolic state. One purported mechanism for this phenomenon is circulating gastrointestinal peptides modulate functioning gustatory system. Recent evidence suggests endocrine signaling oral cavity can influence food intake (FI) and satiety. We these hormones affecting FI by influencing perception. used immunohistochemistry along with genetic knockout models specific reconstitution peptide YY...
Increased visceral fat and sarcopenia are cardiovascular risk factors that may explain increased morbidity frailty in patients with adrenal adenomas. Our objective was to compare body composition measurement of adenomas referent subjects without disease.Cross-sectional study, 2014-2018.Participants were adults nonfunctioning tumor (NFAT), mild autonomous cortisol secretion (MACS), Cushing syndrome (CS) age, sex, BMI 1:1 matched disorders. Main outcome measures measurements calculated from...
Peptide hormones and their cognate receptors belonging to neuropeptide Y (NPY) family mediate diverse biological functions in a number of tissues. Recently, we discovered the presence gut satiation peptide YY (PYY) saliva mice humans defined its role regulation food intake body weight maintenance. Here report systematic analysis expression patterns all NPY (Rs), Y1R, Y2R, Y4R, Y5R lingual epithelia mice. Using four independent assays, immunohistochemistry, situ hybridization,...
Long-term follow-up is important for determining performance characteristics of thyroid fine-needle aspiration (FNA).Histologic or 3 more years clinical was used to calculate FNA before and after implementation The Bethesda System Reporting Thyroid Cytopathology (TBSRTC). impact noninvasive follicular neoplasm with papillary-like nuclear features (NIFTP) classification also investigated.Follow-up obtained 1,277/1,134 1,616/1,393 aspirates/patients (median follow-up, 9.9 4.4 years, pre-...
Obesity is a multifactorial disease with variable and underwhelming weight loss response to current treatment approaches. Precision medicine proposes new paradigm improve classification based on the premise of human heterogeneity, ultimate goal maximizing effectiveness, tolerability, safety. Recent advances in high-throughput biochemical assays have contributed partial characterization obesity's pathophysiology, as well understanding role that intrinsic environmental factors, their...