A5013867431- Synthesis and biological activity
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Crystal structures of chemical compounds
- Computational Drug Discovery Methods
- SARS-CoV-2 and COVID-19 Research
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Concrete Corrosion and Durability
- Bioactive Compounds and Antitumor Agents
- Hydrogen embrittlement and corrosion behaviors in metals
- Corrosion Behavior and Inhibition
- Metal complexes synthesis and properties
- Click Chemistry and Applications
- Cancer therapeutics and mechanisms
- Organic Chemistry Cycloaddition Reactions
- Synthesis and Characterization of Heterocyclic Compounds
- Selenium in Biological Systems
- Synthesis and Catalytic Reactions
- HER2/EGFR in Cancer Research
- CRISPR and Genetic Engineering
- Research on Leishmaniasis Studies
- Mosquito-borne diseases and control
- Synthesis of heterocyclic compounds
- Organoselenium and organotellurium chemistry
Cadi Ayyad University
2018-2023
Laboratoire de Chimie Moléculaire
2017-2018
Abstract A variety of hybrid compounds, combining a camphor thiazolidinone skeleton with either 1,2,3‐triazole or isoxazole nucleus, have been synthesized from natural (R)‐camphor. Our efficient procedure consists in transformation the (R)‐camphor into corresponding thiazolidin‐4‐one. The latter is then N‐alkylated propargyl bromide before submitting resulting product to 1,3‐dipolar cycloaddition reactions, series nitrile oxides and arylazides respectively. chemical structures all newly...
We have studied the inhibitory effect of some Monoterpenic Thiosemicarbazones on steel corrosion in 1 M HCl solution. The potentiodynamic polarization and electrochemical impedance spectroscopy were used. inhibited significantly dissolution steel. inhibition efficiency increased with increasing inhibitor concentration also increase temperature (293–323 K). Furthermore, results obtained revealed that adsorption surface obeys Langmuir model thermodynamic parameters such as enthalpy activation...
This study aimed to analyze the cytotoxic and apoptotic effects of isoxazoline derivatives with monoterpene scaffold 9a-e in HT-1080 fibrosarcoma, MCF-7, MDA-MB-231 breast carcinoma, A-549 lung carcinoma. The data revealed that compounds generally induced significant cell growth inhibition all lines, IC50 ranging from 10 30 µM. However, for 9c 9e, reached a value 100 µM cells. Compounds 9a, 9b, 9d could induce apoptosis cells as demonstrated by Annexin-V labeling Caspase-3/7 activity. effect...
This work deals with the study of inhibition activity three thiazolidinones (prepared from monoterpenic ketones) on deterioration S300 steel in hydrochloric acid solution. The potentiodynamic polarization was used to investigate electrochemical behavior studied inhibitors which were revealed be mixed type ones. It established that compounds have significantly inhibited dissolution highest efficiency 84% at 293 K. increases an increase inhibitor's concentrations ranging between 1 × 10−4 and 5...
COVID-19 is a global pandemic caused by infection with the SARS-CoV-2 virus. Remdesivir, RNA polymerase inhibitor, only drug to have received widespread approval for treatment of COVID-19. The main protease enzyme (M
The synthesis of three new polysubstituted monoterpenic thiazolidin-4-ones, namely (Z)-3-methyl-2-{(E)-[(1R,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ylidene]hydrazinylidene}thiazolidin-4-one, C14H21N3OS (2), (2Z,5Z)-5-[(dimethylamino)methylidene]-2-{(E)-[(1R,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ylidene]hydrazinylidene}thiazolidin-4-one, C16H24N4OS (3), and...
The crystal structure and the conformation of title compound, C
The title compound, C13H19N3OS, is a new thia-zolidin-4-one derivative prepared and isolated as the pure (3aS,6R)-diastereisomer from (R)-thio-semicarbazone pulegone. It crystallized with two independent mol-ecules (A B) in asymmetric unit. compound composed of hexhydro-indazole ring system (viz. five-membered di-hydro-pyrazole fused to cyclo-hexyl ring) thia-zole-4-one attached one pyrazole N atoms (at position 2). overall geometry differs slightly, mean planes thia-zole rings being...
The title compound, C 11 H 19 N 3 S, was prepared by the reaction of ( R )-pulegone with thiosemicarbazide in acidic medium, using ethanol as solvent. molecule is built up from fused six and five-membered rings. six-membered ring adopts a chair conformation, while displays an envelope conformation dimethyl-substituted atom flap. dihedral angle between mean planes two rings 20.35 (6)°. In crystal, molecules are linked N—H...N N—H...S hydrogen bonds into chains running parallel to [100].
COVID-19 is a global pandemic caused by infection with the SARS-CoV-2 virus. Remdesivir, RNA polymerase inhibitor, only drug to have received widespread approval for treatment of COVID-19. The main protease enzyme (MPro), essential viral replication and transcription, remains an active target in search new treatments. In this study, ability novel thiazolyl-indazole derivatives inhibit MPro evaluated. These compounds were synthesized via heterocyclization phenacyl bromide (R)-carvone...
COVID-19 is a global pandemic caused by infection with the SARS-CoV-2 virus. Remdesivir, RNA polymerase inhibitor, only drug to have received widespread approval for treatment of COVID-19. The main protease enzyme (MPro), essential viral replication and transcription, remains an active target in search new treatments. In this study, ability novel thiazolyl-indazole derivatives inhibit MPro evaluated. These compounds were synthesized via heterocyclization phenacyl bromide (R)-carvone...