A5066933911- Synthesis and biological activity
- Click Chemistry and Applications
- Synthesis and Characterization of Heterocyclic Compounds
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Computational Drug Discovery Methods
- Metal complexes synthesis and properties
- Corrosion Behavior and Inhibition
- Crystal structures of chemical compounds
- Synthesis and Biological Evaluation
- Bioactive Compounds and Antitumor Agents
- Concrete Corrosion and Durability
- Inorganic and Organometallic Chemistry
- Crystallography and molecular interactions
- Organic Chemistry Cycloaddition Reactions
- Asymmetric Synthesis and Catalysis
- Molecular spectroscopy and chirality
- Cancer therapeutics and mechanisms
- Essential Oils and Antimicrobial Activity
- Axial and Atropisomeric Chirality Synthesis
- Cancer Mechanisms and Therapy
- Analytical Chemistry and Chromatography
- Research on Leishmaniasis Studies
- Transition Metal Oxide Nanomaterials
- Synthesis and Reactivity of Sulfur-Containing Compounds
Cadi Ayyad University
2021-2025
Université Hassan II Mohammedia
2021
Laboratoire de Chimie Moléculaire
2014
Aseries of novel 1,4-disubstituted 1,2,3-triazoles were synthesized from an (R)-carvone terminal alkyne derivative via a Cu (I)-catalyzed azide-alkyne cycloaddition reaction using CuSO4,5H2O as the copper (II) source and sodium ascorbate reducing agent which reduces into (I). All newly 9a-h fully identified on basis their HRMS NMR spectral data then evaluated for cell growth inhibition potential by MTS assay against HT-1080 fibrosarcoma, A-549 lung carcinoma, two breast adenocarcinoma (MCF-7...
Abstract A variety of hybrid compounds, combining a camphor thiazolidinone skeleton with either 1,2,3‐triazole or isoxazole nucleus, have been synthesized from natural (R)‐camphor. Our efficient procedure consists in transformation the (R)‐camphor into corresponding thiazolidin‐4‐one. The latter is then N‐alkylated propargyl bromide before submitting resulting product to 1,3‐dipolar cycloaddition reactions, series nitrile oxides and arylazides respectively. chemical structures all newly...
A new series of thiazolidinone linked 1,2,3-triazole hybrids 5a-h was designed and synthesized using the copper-catalyzed Huisgen azide-alkyne cycloaddition (CuAAC) between alkyne aromatic azides. The structures newly compounds were established by NMR (1H 13C) HRMS. targeted thiazolidinone-1,2,3-triazole evaluated for their cytotoxic activity against four human cancer cell lines, including fibrosarcoma (HT-1080), lung carcinoma (A-549), breast (MCF-7 MDA-MB-231)...
ABSTRACT Tropical parasitic diseases like leishmaniasis pose significant public health challenges, impacting millions of individuals globally. Current drug treatments for these have notable drawbacks and side effects, underscoring the pressing need new medications with improved selectivity reduced toxicity. Through structural modifications both natural synthetic compounds using click chemistry, researchers been able to produce derivatives showing promising activity against parasites. In this...
Abstract A new 1,2,3‐triazole sesquiterpenic named (4aR,5aS,7aR,10aR,10bR)‐10‐benzyl‐5,5‐dichloro‐1,1,4a,7a‐tetramethyl‐1,2,3,4,4a,5,7a,10,10a,10b decahydrocyclopropa[2′,3′]cyclohepta [1′,2′:3,4]benzo[1,2‐d][1,2,3]triazol‐7(6H)‐one was synthesized by a dipolar cycloaddition 1,3 between benzyl azide and α,β‐unsaturated sesquiterpene ketone catalyzed titanium tetrachloride TiCl 4 . It obtained with good yield characterized using single‐crystal X‐ray diffraction technique, infra red (IR)...
In the current study, natural (R)-carvone was utilized as a starting material for efficient synthesis of two series isoxazoline derivatives bearing 1,3,4-thiadiazole moiety. The new compounds were obtained in good yields and characterized by 1 H 13 C NMR HRMS analysis. newly synthesized monoterpenic their thiosemicarbazone intermediate evaluated anticancer activity four cancer cell lines (HT-1080, A-549, MCF-7, MDA-MB-231). Most exhibited moderate to high effects. Compound 13c showed highest...
This study aimed to analyze the cytotoxic and apoptotic effects of isoxazoline derivatives with monoterpene scaffold 9a-e in HT-1080 fibrosarcoma, MCF-7, MDA-MB-231 breast carcinoma, A-549 lung carcinoma. The data revealed that compounds generally induced significant cell growth inhibition all lines, IC50 ranging from 10 30 µM. However, for 9c 9e, reached a value 100 µM cells. Compounds 9a, 9b, 9d could induce apoptosis cells as demonstrated by Annexin-V labeling Caspase-3/7 activity. effect...
A database of 300 compounds was virtually screened and docked against Bcl-2 protein; the stability best-formed complex evaluated through Molecular dynamics, top ten with best
Background: This study aimed to develop novel isoxazoline-1,3,4-thiadiazole hybrids from (S)-verbenone for potential anticancer treatment, particularly focusing on cytotoxic and apoptotic effects in hormone-sensitive MCF-7 triple-negative MDA-MB-231 breast cancer cells. Methods & results: was used synthesize through 1,3-dipolar cycloaddition, followed by thorough characterization. The compounds were screened across cell lines, showing significant effects. Compound 8b notably induced...
Abstract A variety of novel thiazolidin‐4‐one himachalene derivatives were designed and synthesized through hetero‐cyclization thiosemicarbazone analogs that have previously exhibited strong anticancer activity. The products 2 a – 4 f completely characterized by 1 H NMR, 13 C IR, HRMS later submitted for in vitro evaluation their activity cytotoxicity on panel four human cancer cell lines ( i.eHT‐1080, MCF‐7, A‐549, MDA‐MB‐231). Most the evaluated compounds showed potent antiproliferative...
Aim: A series of 1,3,4-thiadiazole himachalene hybrids were prepared from the treatment a himachalen-4-one thiosemicarbazone derivative with N-aryl-C-ethoxycarbonyl-nitrilimines and diarylnitrilimines via 1,3-dipolar cycloaddition reaction. Materials & methods: The structures confirmed by NMR, IR high-resolution mass spectroscopy (HRMS). Results conclusion: newly synthesized hybrid compounds tested for their in vitro antitumor activities against panel cancer cell lines including fibrosarcoma...