A5072192321- Synthesis and biological activity
- Click Chemistry and Applications
- Synthesis and Characterization of Heterocyclic Compounds
- Computational Drug Discovery Methods
- Corrosion Behavior and Inhibition
- Synthesis and Biological Evaluation
- Organic Chemistry Cycloaddition Reactions
- Bioactive Compounds and Antitumor Agents
- Metal complexes synthesis and properties
- Fungal Plant Pathogen Control
- Cancer therapeutics and mechanisms
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Crystal structures of chemical compounds
- Concrete Corrosion and Durability
- Organometallic Compounds Synthesis and Characterization
- Multicomponent Synthesis of Heterocycles
- Chemical and Physical Properties in Aqueous Solutions
- Synthesis of heterocyclic compounds
- Synthesis and Reactivity of Heterocycles
- Quinazolinone synthesis and applications
- Cancer Mechanisms and Therapy
- Transition Metal Oxide Nanomaterials
- Hydrogen embrittlement and corrosion behaviors in metals
- Chemical Reaction Mechanisms
- Thermodynamic properties of mixtures
Cadi Ayyad University
2021-2024
Université Hassan II Mohammedia
2020-2021
Pfizer (United Kingdom)
1980
In the current study, natural (R)-carvone was used as starting material for efficient synthesis of several 1,2,3-triazole derivatives. The produced products were obtained in good yields and characterized by 1H 13C NMR HRMS analysis. newly synthesized monoterpenic 4 derivatives analyzed viability tests (MTT) their cytotoxic activity against three human cancer cells. Product 5 showed a medium antitumor activity, which IC50 values selected cells HT-1080, A-549 MCF-7 29.25 μM, 31.62 μM 26.02...
Aseries of novel 1,4-disubstituted 1,2,3-triazoles were synthesized from an (R)-carvone terminal alkyne derivative via a Cu (I)-catalyzed azide-alkyne cycloaddition reaction using CuSO4,5H2O as the copper (II) source and sodium ascorbate reducing agent which reduces into (I). All newly 9a-h fully identified on basis their HRMS NMR spectral data then evaluated for cell growth inhibition potential by MTS assay against HT-1080 fibrosarcoma, A-549 lung carcinoma, two breast adenocarcinoma (MCF-7...
Abstract A variety of hybrid compounds, combining a camphor thiazolidinone skeleton with either 1,2,3‐triazole or isoxazole nucleus, have been synthesized from natural (R)‐camphor. Our efficient procedure consists in transformation the (R)‐camphor into corresponding thiazolidin‐4‐one. The latter is then N‐alkylated propargyl bromide before submitting resulting product to 1,3‐dipolar cycloaddition reactions, series nitrile oxides and arylazides respectively. chemical structures all newly...
Abstract A series of C(2)‐N(4)‐disubstituted 1,3,4‐thiadiazoles bearing dichlorocyclopropane, have been prepared from (R)‐carvone 1 in a three‐step procedure. First, was treated with dichlorocarbene, generated in‐situ chloroform using PTC technique. The resulting dichlorocyclopropane 2 then converted into thiosemicarbazone derivatives 3 – c before being transformed peri‐selectively and efficiently (up to 80 % yield) their corresponding ( 6 d 7 ) via 1,3‐dipolar cycloaddition reaction...
A new series of thiazolidinone linked 1,2,3-triazole hybrids 5a-h was designed and synthesized using the copper-catalyzed Huisgen azide-alkyne cycloaddition (CuAAC) between alkyne aromatic azides. The structures newly compounds were established by NMR (1H 13C) HRMS. targeted thiazolidinone-1,2,3-triazole evaluated for their cytotoxic activity against four human cancer cell lines, including fibrosarcoma (HT-1080), lung carcinoma (A-549), breast (MCF-7 MDA-MB-231)...
In the current study, natural (R)-carvone was utilized as a starting material for efficient synthesis of two series isoxazoline derivatives bearing 1,3,4-thiadiazole moiety. The new compounds were obtained in good yields and characterized by 1 H 13 C NMR HRMS analysis. newly synthesized monoterpenic their thiosemicarbazone intermediate evaluated anticancer activity four cancer cell lines (HT-1080, A-549, MCF-7, MDA-MB-231). Most exhibited moderate to high effects. Compound 13c showed highest...
This study aimed to analyze the cytotoxic and apoptotic effects of isoxazoline derivatives with monoterpene scaffold 9a-e in HT-1080 fibrosarcoma, MCF-7, MDA-MB-231 breast carcinoma, A-549 lung carcinoma. The data revealed that compounds generally induced significant cell growth inhibition all lines, IC50 ranging from 10 30 µM. However, for 9c 9e, reached a value 100 µM cells. Compounds 9a, 9b, 9d could induce apoptosis cells as demonstrated by Annexin-V labeling Caspase-3/7 activity. effect...
A database of 300 compounds was virtually screened and docked against Bcl-2 protein; the stability best-formed complex evaluated through Molecular dynamics, top ten with best
Background: This study aimed to develop novel isoxazoline-1,3,4-thiadiazole hybrids from (S)-verbenone for potential anticancer treatment, particularly focusing on cytotoxic and apoptotic effects in hormone-sensitive MCF-7 triple-negative MDA-MB-231 breast cancer cells. Methods & results: was used synthesize through 1,3-dipolar cycloaddition, followed by thorough characterization. The compounds were screened across cell lines, showing significant effects. Compound 8b notably induced...
Abstract A variety of novel thiazolidin‐4‐one himachalene derivatives were designed and synthesized through hetero‐cyclization thiosemicarbazone analogs that have previously exhibited strong anticancer activity. The products 2 a – 4 f completely characterized by 1 H NMR, 13 C IR, HRMS later submitted for in vitro evaluation their activity cytotoxicity on panel four human cancer cell lines ( i.eHT‐1080, MCF‐7, A‐549, MDA‐MB‐231). Most the evaluated compounds showed potent antiproliferative...
Aim: A series of 1,3,4-thiadiazole himachalene hybrids were prepared from the treatment a himachalen-4-one thiosemicarbazone derivative with N-aryl-C-ethoxycarbonyl-nitrilimines and diarylnitrilimines via 1,3-dipolar cycloaddition reaction. Materials & methods: The structures confirmed by NMR, IR high-resolution mass spectroscopy (HRMS). Results conclusion: newly synthesized hybrid compounds tested for their in vitro antitumor activities against panel cancer cell lines including fibrosarcoma...
Abstract Herein, we report the synthesis of a novel series β‐himachalene derivatives, including semicarbazones, thiosemicarbazones, and thiazoles. The structures these compounds were elucidated by NMR, IR, HRMS analysis methods. in vitro antitumor activity was evaluated MTT assay against four human cancer cell lines, such as fibrosarcoma (HT‐1080), breast adenocarcinoma (MCF‐7 MDA‐MB‐231), lung carcinoma (A‐549), results indicated that all showed moderate to significant cytotoxic activities...
A series of novel 2-iminothiazolidin-4-one analogs have been synthesized from limonaketone, and structurally characterized by HR-MS, 1 H-NMR 13 C-NMR spectroscopy techniques, the structure compound 4 was elucidated XRD. The newly products were biologically evaluated in vitro for their cytotoxic activity against human cancer cell lines HT-1080, A549, MCF-7. Thiazolidinones 9 10 most active compounds HT-1080 (IC50 =15.85±1.75 16.13±1.55 μM, respectively). apoptosis induction derivatives...