A5015453182- Global Cancer Incidence and Screening
- Cancer Risks and Factors
- Colorectal Cancer Screening and Detection
- Digital Radiography and Breast Imaging
- AI in cancer detection
- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Radiomics and Machine Learning in Medical Imaging
- COVID-19 and healthcare impacts
- Cancer Diagnosis and Treatment
- Cervical Cancer and HPV Research
- BRCA gene mutations in cancer
- Nutritional Studies and Diet
- Urological Disorders and Treatments
- Medical Imaging Techniques and Applications
- Management of metastatic bone disease
- Urinary Bladder and Prostate Research
- Gene expression and cancer classification
- Ultrasound and Hyperthermia Applications
- Ultrasound Imaging and Elastography
- Healthcare Systems and Challenges
- Pelvic floor disorders treatments
- Nutrition, Genetics, and Disease
- Brain Metastases and Treatment
- Prostate Cancer Diagnosis and Treatment
Gentofte Hospital
2022-2025
Rigshospitalet
2012-2024
Copenhagen University Hospital
2014-2024
University of Copenhagen
2004-2023
Radboud University Nijmegen
2023
Radboud University Medical Center
2023
Capital Region of Denmark
2012-2016
Region Zealand
2016
National Board of Health
2005
Danish Cancer Society
2005
Background Retrospective studies have suggested that using artificial intelligence (AI) may decrease the workload of radiologists while preserving mammography screening performance. Purpose To compare and performance for two cohorts women who underwent before after AI system implementation. Materials Methods This retrospective study included 50–69-year-old biennial in Capital Region Denmark. Before implementation (October 1, 2020, to November 17, 2021), all screenings involved double...
To evaluate the effect on breast cancer mortality during first 10 years of mammography service screening programme that was introduced in Copenhagen 1991.Cohort study.The Copenhagen, Denmark.All women ever invited to programme. Historical, national, and historical national control groups were used.The main outcome measure mortality. We compared study group with rates groups, adjusting for age, time period, region.Breast period reduced by 25% (relative risk 0.75, 95% confidence interval 0.63...
EUSOBI and 30 national breast radiology bodies support mammography for population-based screening, demonstrated to reduce cancer (BC) mortality treatment impact. According the International Agency Research on Cancer, reduction in is 40 % women aged 50–69 years taking up invitation while probability of false-positive needle biopsy <1 per round overdiagnosis only 1–10 a 20-year screening. Mortality was also observed age groups 40–49 70–74 years, although with “limited evidence”. Thus, we...
Abstract Background Screening mammography works better in fatty than dense breast tissue. Computerized assessment of parenchymal texture is a non-subjective method to obtain refined description tissue, potentially valuable addition density scoring for the identification women need supplementary imaging. We studied sensitivity screening by combination radiologist-assessed Breast Imaging Reporting and Data System (BI-RADS) score computer-assessed marker, resemblance (MTR), population-based...
High breast density, a strong predictor of cancer may be determined early in life. Childhood anthropometric factors have been related to and but rarely simultaneously. We examined whether mammographic density (MD) mediates an association birth weight, childhood body mass index (BMI), height with the risk cancer. 13,572 women (50 69 years) Copenhagen mammography screening program (1991 through 2001) measurements School Health Records Register were followed for until 2010. With logistic Cox...
<b>Objective</b> To use data from two longstanding, population based screening programmes to study overdiagnosis in mammography. <b>Design</b> Population cohort study. <b>Setting</b> Copenhagen municipality (from 1991) and Funen County 1993), Denmark. <b>Participants</b> 57 763 women targeted by organised screening, aged 56-69 when the started, followed up 2009. <b>Main outcome measures</b> Overdiagnosis of breast cancer assessed relative risks compared with historical control groups...
Delivery of screening mammography differs substantially between the United States (US) and Denmark. We evaluated whether there are differences in sensitivity specificity. included screens from women screened at age 50–69 years during 1996–2008/2009 US Breast Cancer Surveillance Consortium (BCSC) ( n = 2,872,791), two population‐based programs Denmark (Copenhagen, 148,156 Funen, 275,553). Women were followed‐up for 1 year. For initial screens, recall rate was significantly higher BCSC (17.6%)...
Hormone replacement therapy (HRT) use increases breast cancer risk and mammographic density (MD). We examine whether MD mediates or modifies the association of HRT with cancer. For 4,501 participants in Danish diet, health cohort (1993–1997) who attended screening Copenhagen (1993–2001), (mixed/dense fatty) was assessed at first after entry. by questionnaire diagnoses until 2012 obtained from registry. The associations were analyzed separately using Cox's regression. Mediation analyses used...
Denmark was one of the few countries where it politically decided to continue cancer screening during COVID-19 pandemic. We assessed actual population uptake mammography and cervical this period.The first lockdown in announced on 11 March 2020. To investigate possible changes activity due pandemic, we analysed data from beginning 2017 until end 2021. A time series analysis carried out discover trends outliers activities period 2017-2021. Data were retrieved governmental pandemic-specific...
The occurrence of bone marrow carcinosis was investigated in 380 patients at the time first recurrence breast cancer. Results were related to results from radiographic survey, 99mTc MDP scintigraphy, clinical examination and serum alkaline phosphatase calcium levels. Eighty-seven (23%) had tumor cells marrow. X-rays showed metastases 78% with 16% without carcinosis. diagnostic efficiency x-rays biopsy as key factor 83%, it superior that other investigation methods. Bone tissue biopsies...
Metastatic bone disease was evaluated in 380 consecutive patients at the time of first metastasis breast cancer. Studies included radiographic examination, radionuclide and marrow biopsy. Radiographs skeleton demonstrated metastases 120 (32%), 40 these (13%) only site metastases. The diagnostic efficiency 82% for scanning, 80% pain evaluation, 59% s-calcium analyses, 77% s-alkaline phosphatase analyses. Bone scanning is an effective method to exclude metastatic (sensitivity: 96%). A positive...
Mammographic density is a well-established risk factor for breast cancer. We investigated the association between three different methods of measuring or parenchymal pattern/texture on digitized film-based mammograms, and examined to what extent textural features independently jointly with can improve ability identify screening women at increased The study included 121 cases 259 age- time matched controls based cohort 14,736 negative mammograms from population-based programme in Denmark 2007...
Purpose Randomized, controlled trials showed that screening reduces breast cancer mortality rates, but some recent observational studies have concluded programmatic has had minor effect on rates. This apparent contradiction might be explained by the use of aggregated data in studies. We assessed long-term using individual-level data. Materials and Methods Using from mammography Copenhagen Danish national registers, we compared observed rate women invited to with expected absence screening....
Background Recent mammography-based risk models can estimate short-term or long-term breast cancer risk, but whether assessment may improve by combining these has not been evaluated. Purpose To determine improves when a diagnostic artificial intelligence (AI) system for lesion detection and mammographic texture model. Materials Methods This retrospective study included Danish women consecutively screened at mammography from November 2012 to December 2015 who had least 5 years of follow-up...
Background: Attention in the 2000s on importance of mammographic density led us to study screening sensitivity, breast cancer incidence, and associations with risk factors by Danish programs. Here, we summarise our approaches findings. Methods: Dichotomized codes: fatty, equal BI-RADS code 1 part 2, other mixed/dense data from 1990s—were available two counties, codes one region were 2012/13. Density linked vital status, incident cancer, potential factors. We calculated sensitivity combining...
Abstract Axillary lymph node status is an important prognostic factor for breast cancer patients and sentinel biopsy (SLNB) a less invasive surgical proxy. We examined if consecutively derived molecular subtypes from primary cancers provide additional predictive value SLNB status. 1556 with > 10 mm underwent procedure including tumor specimens were assigned transcriptomics-based subtype. 1020 had negative (SN) 536 positive. A significant association between size SN ( p < 0.0001) was...
Objectives: The objectives of this study was to provide a simple estimate the cumulative risk false-positive test for women participating in mammography screening. To method, we used data from two well-established, organized screening programmes offering biennial aged 50–69 years Copenhagen and Fyn, Denmark. Methods: We defined outcome screen as being either or not test. then tested whether outcomes subsequent screens were independent, afterwards estimated over 10 test, i.e. getting at least...
Mammographic breast density and parenchymal patterns are well-established risk factors for cancer. We aimed to report inter-observer agreement on three different subjective ways of assessing mammographic pattern, secondarily examine what potential impact reproducibility has relative estimates This retrospective case–control study included 122 cases 262 age- time matched controls (765 breasts) based a 2007 screening cohort 14,736 women with negative mammograms from Bispebjerg Hospital,...
The currently recommended double reading of all screening mammography examinations is an economic burden for programs. sensitivity higher women with low breast density than high density. One may therefore ask whether single could replace at least We addressed this question using data from a program where the radiologists coded their readings independently.Data include in Capital Region Denmark 1 November 2012 to 31 December 2013. Outcome was assessed by linkage Danish Pathology Register....
Cancer risk varies geographically, and migrants are influenced by different factors before, during after migration. Increased migration from non-Western countries to the Nordic calls for a better understanding of migrants' cancer change in patterns over time. The aim this study was compare incidence mortality breast, colorectal lung between immigrant native female population Denmark, Finland, Iceland, Norway.Data national registries were processed pre-analysed each country. Multivariate...