A5032545904- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- MicroRNA in disease regulation
- Seismic Imaging and Inversion Techniques
- Cell death mechanisms and regulation
- Extracellular vesicles in disease
- Geophysical and Geoelectrical Methods
- Reservoir Engineering and Simulation Methods
- RNA Interference and Gene Delivery
- Seismic Waves and Analysis
- Acute Myeloid Leukemia Research
- Circular RNAs in diseases
- Ubiquitin and proteasome pathways
- Phagocytosis and Immune Regulation
- Chronic Myeloid Leukemia Treatments
- FOXO transcription factor regulation
- Cancer-related Molecular Pathways
- Cancer Mechanisms and Therapy
- Geochemistry and Geologic Mapping
- Peptidase Inhibition and Analysis
- earthquake and tectonic studies
- Cell Adhesion Molecules Research
- Advanced biosensing and bioanalysis techniques
- Seismology and Earthquake Studies
- Cancer therapeutics and mechanisms
Centro di Riferimento Oncologico della Basilicata
2014-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2014-2023
Schlumberger (British Virgin Islands)
2009-2022
Ospedale Maggiore
2013-2022
Ospedale Maria Vittoria
2022
Azienda Sanitaria Locale di Asti
2022
Centro Cardiologico Monzino
2022
Azienda Ospedaliero-Universitaria Careggi
2022
Ospedale San Carlo
2022
Hospital Clínico San Carlos
2022
Many cell types release extracellular vesicles (EVs), including exosomes, microvesicles (MVs), and apoptotic bodies, which play a role in physiology diseases. Presence phenotype of circulating EVs hematological malignancies (HMs) remain largely unexplored.The aim this study was to characterize peripheral blood HM patients compared healthy subjects (controls). We isolated serum from with chronic lymphocytic leukemia (CLL), non-Hodgkin's lymphoma (NHL), Waldenstrom's macroglobulinemia (WM),...
Numerous studies have described the altered expression and causal role of microRNAs (miRNAs) in human cancer. However, to date, efforts modulate miRNA levels for therapeutic purposes been challenging implement. Here we find that nucleolin (NCL), a major nucleolar protein, posttranscriptionally regulates specific subset miRNAs, including miR-21, miR-221, miR-222, miR-103, are causally involved breast cancer initiation, progression, drug resistance. We also show NCL is commonly overexpressed...
// Luciana De Luca 1 , Stefania Trino Ilaria Laurenzana Vittorio Simeon Giovanni Calice Raimondo 2 Marina Podestà 3 Michele Santodirocco 4 Lazzaro Di Mauro Francesco La Rocca Antonella Caivano Annalisa Morano Frassoni 5 Daniela Cilloni Luigi Del Vecchio 6, 7, * Pellegrino Musto 8, Laboratory of Preclinical and Translational Research, IRCCS-Centro di Riferimento Oncologico della Basilicata (CROB), Rionero in Vulture, 85028, Italy Department Clinical Biological Sciences, University...
Primary plasma cell leukemia (pPCL) is a rare and very aggressive form of dyscrasia. To date, no information on microRNA (miRNA) expression in pPCL has been reported. This study aimed at investigating the involvement miRNAs their possible relationship with higher tumor aggressiveness.Global miRNA profiles were analyzed highly purified malignant cells from 18 untreated patients included prospective clinical trial. MiRNA patterns evaluated comparison representative series multiple myeloma...
Primary plasma cell leukemia (pPCL) is a rare, yet aggressive form of de novo tumor, distinct from secondary PCL (sPCL) which represents leukemic transformation pre-existing multiple myeloma (MM). Herein, we performed comprehensive molecular analysis prospective series pPCLs by means FISH, single nucleotide polymorphism (SNP) array and gene expression profiling (GEP). IGH@ translocations were identified in 87% pPCL cases, with prevalence t(11;14) (40%) t(14;16) (30.5%), whereas the most...
Abstract Purpose: Plasma cell leukemia (PCL) is a rare form of plasma dyscrasia that presents either as progression previously diagnosed multiple myeloma, namely secondary PCL, or initial manifestation disease, primary PCL (pPCL). Although the presenting signs and symptoms include those seen in pPCL characterized by several aspects define more aggressive course. Here, we have investigated transcriptome pPCLs correlated differential expression profiles with outcome to provide insights into...
Introduction Acute Myeloid Leukemia (AML) cells communicate with surrounding normal cells, including hematopoietic stem progenitor (HSPCs), in the bone marrow, and modify their fate supporting tumor growth. This communication can be mediated by Extracellular Vesicles (EVs), small vectors carrying a range of molecular information. One hallmarks AML is aberrant DNA methylation. It not known if how epigenomic profile healthy HSPCs. Here, we investigated methylation HSPCs after exposure to...
Microvescicles (MV) are shedding particles released by normal and neoplastic cells, whose levels in biological fluids highlight their potential role as disease biomarkers therapeutic targets. By analyzing 131 newly diagnosed chronic lymphocytic leukemia (CLL), we found that the absolute number of serum CLL MV was significantly higher than controls, particular advanced stages disease. In addition, CD19 + CD37+, B-cell derived MV, correlated with high tumor burden. Absolute cutoff selected ROC...
Lin28A is a highly conserved RNA-binding protein that concurs to control the balance between stemness and differentiation in several tissue lineages. Here, we report role of miR-128a/Lin28A axis blocking cell acute myeloid leukemia (AML), genetically heterogeneous disease characterized by abnormally controlled proliferation progenitor cells accompanied partial or total inability undergo terminal differentiation. First, found underexpressed blast from AML patients lines as compared with CD34+...
MicroRNAs (miRNAs) are short non-coding RNAs that play critical roles in numerous cellular processes through post-transcriptional regulating functions. The aberrant role of miRNAs has been reported a number haematopoietic malignancies including multiple myeloma (MM). In this review we summarize the current knowledge on pathogenesis MM.
// Stefania Trino 1 , Ilaria Iacobucci 2 Daniela Erriquez 3 Laurenzana Luciana De Luca Anna Ferrari Andrea Ghelli Luserna Di Rorà Cristina Papayannidis Enrico Derenzini Giorgia Simonetti Annalisa Lonetti 4 Claudia Venturi Federica Cattina 5 Emanuela Ottaviani Maria Chiara Abbenante Domenico Russo Giovanni Perini Pellegrino Musto 6 Martinelli Laboratory of Pre-Clinical and Translational Research, IRCCS Referral Cancer Center Basilicata, Rionero in Vulture (PZ), Italy Department Experimental,...
Introduction: Extracellular vesicles (EVs) are naturally secreted cellular lipid bilayer particles, which carry a selected molecular content. Owing to their systemic availability and role in tumor pathogenesis, circulating EVs (cEVs) can be valuable source of new biomarkers useful for diagnosis, prognostication monitoring. However, precise approach isolation characterization cEVs as biomarkers, exportable clinical setting, has not been conclusively established. Methods: We developed novel...
Acute myeloid leukemia (AML) is an aggressive and heterogeneous clonal disorder of hematopoietic stem/progenitor cells (HSPCs). It not well known how alter hematopoiesis promoting tumor growth leukemic niche formation. In this study, we investigated AML deregulates the process HSPCs through release extracellular vesicles (EVs). First, found that released a population EVs containing microRNAs involved in pathogenesis. Notably, AML-EVs were able to influence fate modifying their transcriptome....