Jingwen Guan

ORCID: 0000-0003-1759-2172
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Research Areas
  • X-ray Diffraction in Crystallography
  • Crystallization and Solubility Studies
  • Crystallography and molecular interactions
  • Carbon Nanotubes in Composites
  • Graphene research and applications
  • Bacteriophages and microbial interactions
  • Boron and Carbon Nanomaterials Research
  • Radioactive element chemistry and processing
  • Lanthanide and Transition Metal Complexes
  • Organometallic Complex Synthesis and Catalysis
  • Bacterial Genetics and Biotechnology
  • MXene and MAX Phase Materials
  • Conducting polymers and applications
  • Fiber-reinforced polymer composites
  • Coordination Chemistry and Organometallics
  • CRISPR and Genetic Engineering
  • Thermal properties of materials
  • MicroRNA in disease regulation
  • Cancer-related molecular mechanisms research
  • Advanced biosensing and bioanalysis techniques
  • Enzyme Production and Characterization
  • Polymer Nanocomposites and Properties
  • Smart Materials for Construction
  • Ferroptosis and cancer prognosis
  • Carbohydrate Chemistry and Synthesis

University of California, San Francisco
2020-2025

Anhui Medical University
2020-2025

Wuyi University
2025

Northern Jiangsu People's Hospital
2025

National Research Council Canada
2011-2024

Soochow University
2019-2024

Texas A&M University
2015-2024

Nanjing University of Information Science and Technology
2024

Nanjing University of Science and Technology
2024

Jilin Normal University
2024

Boron nitride nanotubes (BNNTs) exhibit a range of properties that are as compelling those carbon (CNTs); however, very low production volumes have prevented the science and technology BNNTs from evolving at even fraction pace CNTs. Here we report high-yield small-diameter pure hexagonal boron powder in an induction thermal plasma process. Few-walled, highly crystalline (∼5 nm) produced exclusively unprecedentedly high rate approaching 20 g/h, without need for metal catalysts. An...

10.1021/nn501661p article EN ACS Nano 2014-05-07

A multifunctional architecture for biomedical applications has been developed by deliberately combining the useful functions of superparamagnetism, luminescence, and surface functionality into one material. Good control core−shell achieved employing a sol−gel synthesis. Superparamagnetic iron oxide nanoparticles are first coated with silica to isolate magnetic core from surrounding. Subsequently, dye molecules doped inside second shell improve photostability allow versatile functionalities....

10.1021/cm052067x article EN Chemistry of Materials 2006-03-14

Numerous studies have described the altered expression and causal role of microRNAs (miRNAs) in human cancer. However, to date, efforts modulate miRNA levels for therapeutic purposes been challenging implement. Here we find that nucleolin (NCL), a major nucleolar protein, posttranscriptionally regulates specific subset miRNAs, including miR-21, miR-221, miR-222, miR-103, are causally involved breast cancer initiation, progression, drug resistance. We also show NCL is commonly overexpressed...

10.1084/jem.20120950 article EN cc-by-nc-sa The Journal of Experimental Medicine 2013-04-22

Boron nitride nanotubes (BNNTs) exhibit a range of properties that hold great potential for many fields science and technology; however, they have inherently low chemical reactivity, making functionalization specific applications difficult. Here we propose covalent BNNTs via reduction chemistry could be highly promising viable strategy. Through density functional theory calculations the electron affinity their binding energies with various radicals, reveal reactivity can significantly...

10.1021/acsnano.5b06523 article EN ACS Nano 2015-11-18

Jumbo bacteriophages of the ϕKZ-like family assemble a lipid-based early phage infection (EPI) vesicle and proteinaceous nucleus-like structure during infection. These structures protect from nucleases may create selective pressure for immunity mechanisms targeting this specific family. Here, we identify "jumbo killer" (Juk), two-component immune system that terminates phages, suppressing expression genes preventing DNA replication nucleus assembly while saving cell. JukA (formerly YaaW)...

10.1016/j.cell.2025.02.016 article EN cc-by-nc Cell 2025-03-01

A novel method combining wet chemistry for synthesis of an Fe core, 532 nm laser irradiation nanoparticles and Au powder in liquid medium deposition shell, sequential magnetic extraction/acid washing purification has been developed to fabricate oxidation-resistant Fe@Au core-shell nanoparticles. The have extensively characterized at various stages during up several months after completion the by a suite electron microscopy techniques (HRTEM, HAADF STEM, EDX), X-ray diffraction (XRD), UV-vis...

10.1021/jp0560967 article EN The Journal of Physical Chemistry B 2006-03-23

225Ac is considered as one of the most promising radioisotopes for alpha-therapy because its emitted high-energy α-particles can efficiently damage tumor cells. However, it also represents a significant threat to healthy tissues owing extremely high radiotoxicity if targeted therapy fails. This calls pressing requirement monitoring biodistribution in vivo during treatment tumors. lack imageable photons or positrons from therapeutic doses makes this task currently quite challenging. We report...

10.1021/jacs.3c02325 article EN Journal of the American Chemical Society 2023-06-27

We present the results of controlled synthesis core−shell nanostructures and influence silica coating on magnetic properties formed hybrid nanoparticles. The nanoarchitectures composed iron oxide cores amorphous shells have been synthesized through a sol−gel approach characterized by transmission electron microscopy, energy dispersive X-ray analysis, magnetometry. It is found that many nanoparticles contain single core. A good control shell thickness (10−100 nm) has achieved adjusting silane...

10.1021/jp0665067 article EN The Journal of Physical Chemistry C 2007-01-12

Single-walled carbon nanotubes (SWCNTs) have been used as fillers to produce electrically conductive composite papers. While papers made using other fillers, they either suffer from instability or low conductivity. Using simple papermaking techniques, we SWCNT–cellulose paper which possesses a conductivity of 3 × 10−2 S cm−1 and is comparable exceeds reports nanotube–cellulose by layer-by-layer assembly. These are multifunctional, having both improved electrical enhanced flame retardant...

10.1039/b924260k article EN Journal of Materials Chemistry 2010-01-01

Reduced single-walled carbon nanotubes (r-SWCNT) are shown to react readily at room temperature under inert atmosphere conditions with epoxide moieties, such as those in triglycidyl p-amino phenol (TGAP), produce a soft covalently bonded interface around the SWCNT. The is compatible SWCNT-free cross-linked cured matrix and acts toughener for composite. Incorporation of 0.2 wt % r-SWCNT enhances ultimate tensile strength, toughness fracture by 32, 118, 40%, respectively, without change...

10.1021/am200523z article EN ACS Applied Materials & Interfaces 2011-05-25

While production of engineered carbon nanotubes (CNTs) has escalated in recent years, knowledge risk associated with exposure to these materials remains unclear. We report on the cytotoxicity four CNT variants human lung epithelial cells (A549) and murine macrophages (J774). Morphology, metal content, aggregation/agglomeration state, pore volume, surface area modifications were determined for pristine oxidized single-walled (SW) multi-walled (MW) CNTs. Cytotoxicity was evaluated by cellular...

10.3109/17435390.2014.902519 article EN Nanotoxicology 2014-04-09

Boron nitride, which possesses high thermal conductivity, is often incorporated into polymer matrixes for management. The enhancement in the conductivity depends on filler shape, size, effective dispersion matrix, and interfacial resistance between last two are most challenging issues. To address these challenges, this study different covalent functionalization approaches boron nitride nanotubes (BNNTs) with short polyethylene (PE) chains employed: one based Williamson reaction other nitrene...

10.1021/acsanm.8b01992 article EN ACS Applied Nano Materials 2018-12-20

An agent for actinide sequestration with fast uranium uptake kinetics and efficient in vivo removal using a nanoscale metal-organic framework (nano-MOF) is proposed. UiO-66 nanoparticles post-synthetically functionalized carboxyl groups, UiO-66-(COOH)4 -180, exhibit the fastest reported more than 65 % of uranyl fetal bovine serum (FBS) removed within 5 min. Moreover, bio-distribution studies show that material partially accumulates kidneys femurs where mainly deposits facilitating uranium....

10.1002/anie.202012512 article EN Angewandte Chemie International Edition 2020-10-08

Current processes to manufacture nanotubes at commercial scales are unfortunately imperfect and commonly generate undesirable byproducts. After manufacturing, purification is necessary a rate cost determining step in advancing the development of products based on nanotubes. Boron nitride (BNNTs) produced without metal catalysts from high-temperature known contain significant amount (e.g., 50 wt %) various boron derivatives. Herein we report simple yet efficient scalable process purify these...

10.1021/acs.chemmater.0c00144 article EN Chemistry of Materials 2020-04-09

Single-walled carbon nanotubes (SWCNTs) covalently modified with OH functional groups were assembled into buckypapers through solvent dispersion and vacuum filtration. These SWCNT-OH buckypaper sheets subsequently crosslinked by wetting bifunctional linkers followed hot compression causing reaction between the of reagent on side-walls SWCNTs to create three-dimensional (3D) cross-linked buckypapers. Cross-linking also was performed using encapsulated a functionalized polymer wrapping in...

10.1039/c4ra12026d article EN RSC Advances 2014-11-04

The fabrication of BNNT–polymer nanocomposites, including BNNT–epoxy and BNNT–polyurethane has been demonstrated for the first time from free-standing BNNT buckypapers.

10.1039/c5ra02988k article EN RSC Advances 2015-01-01

Abstract Background Macroalgae and microalgae, as feedstocks for third-generation biofuel, possess competitive strengths in terms of cost, technology economics. The most important compound brown macroalgae is alginate, the synergistic effect endolytic exolytic alginate lyases plays a crucial role saccharification process transforming into biofuel. However, there are few studies on lyases, especially those from same bacterial strain. Results In this study, lyase AlyPB1 AlyPB2 were identified...

10.1186/s13068-019-1600-y article EN cc-by Biotechnology for Biofuels 2019-11-04
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