A5064976355- Chronic Lymphocytic Leukemia Research
- Multiple Myeloma Research and Treatments
- Cell death mechanisms and regulation
- Phagocytosis and Immune Regulation
- MicroRNA in disease regulation
- Glycosylation and Glycoproteins Research
- RNA Interference and Gene Delivery
- FOXO transcription factor regulation
- Ubiquitin and proteasome pathways
- Peptidase Inhibition and Analysis
- Circular RNAs in diseases
- Acute Myeloid Leukemia Research
- Lymphoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- DNA Repair Mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related Molecular Pathways
- Protease and Inhibitor Mechanisms
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Prostate Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Glutathione Transferases and Polymorphisms
- Epigenetics and DNA Methylation
- Neutropenia and Cancer Infections
- Microbial bioremediation and biosurfactants
Istituti di Ricovero e Cura a Carattere Scientifico
2010-2024
Centro di Riferimento Oncologico della Basilicata
2010-2024
Institut de Chimie de Strasbourg
2022
Université de Strasbourg
2022
Centre National de la Recherche Scientifique
2022
Advanced Cell Diagnostics (United States)
2014
Casa Sollievo della Sofferenza
2013
University of Milan
2013
Ospedale Maggiore
2013
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2013
Primary plasma cell leukemia (pPCL) is a rare and very aggressive form of dyscrasia. To date, no information on microRNA (miRNA) expression in pPCL has been reported. This study aimed at investigating the involvement miRNAs their possible relationship with higher tumor aggressiveness.Global miRNA profiles were analyzed highly purified malignant cells from 18 untreated patients included prospective clinical trial. MiRNA patterns evaluated comparison representative series multiple myeloma...
Primary plasma cell leukemia (pPCL) is a rare, yet aggressive form of de novo tumor, distinct from secondary PCL (sPCL) which represents leukemic transformation pre-existing multiple myeloma (MM). Herein, we performed comprehensive molecular analysis prospective series pPCLs by means FISH, single nucleotide polymorphism (SNP) array and gene expression profiling (GEP). IGH@ translocations were identified in 87% pPCL cases, with prevalence t(11;14) (40%) t(14;16) (30.5%), whereas the most...
Abstract Purpose: Plasma cell leukemia (PCL) is a rare form of plasma dyscrasia that presents either as progression previously diagnosed multiple myeloma, namely secondary PCL, or initial manifestation disease, primary PCL (pPCL). Although the presenting signs and symptoms include those seen in pPCL characterized by several aspects define more aggressive course. Here, we have investigated transcriptome pPCLs correlated differential expression profiles with outcome to provide insights into...
Gastric cancer, the second most common cause of death worldwide, is characterized by poor prognosis and low responsiveness to chemotherapy. Indeed, multidrug resistance, based mainly on cellular molecular factors, remains one limiting factors current approach gastric cancer (GC) therapy. We employed a comprehensive gene expression analysis through data mining publicly available databases assess role signal transducer activator transcription 3 (STAT3) in drug efficiency. It has been proposed...
Lin28A is a highly conserved RNA-binding protein that concurs to control the balance between stemness and differentiation in several tissue lineages. Here, we report role of miR-128a/Lin28A axis blocking cell acute myeloid leukemia (AML), genetically heterogeneous disease characterized by abnormally controlled proliferation progenitor cells accompanied partial or total inability undergo terminal differentiation. First, found underexpressed blast from AML patients lines as compared with CD34+...
High purity alumina as well zirconia ceramics have been widely used orthopaedic implant biomaterials and dental devices displaying optimal, but sometimes exclusive, mechanical properties. In order to combine the advantages of ceramic materials different types composites developed in which either is dispersed an matrix or vice versa. Orthopaedic are expected be contact with living tissues for a long period time their term toxicity must carefully evaluated. this study we report development...
Abstract The epidermal growth factor (EGF) plays a role in the development of prostate cancer, which becomes essential after androgen resistance has emerged. EGF receptor (EGFR) is therefore potential target for anticancer therapy. We evaluated effects ZD1839 (‘Iressa’), an orally active EGFR—tyrosine kinase inhibitor, on cancer cell lines. were anchorage dependent and independent androgen‐responsive (LNCaP) androgen‐independent (DU145 PC3) cells by proliferation assay, counting, soft agar...
Methyl tertiary butyl ether (MTBE) is the most widely used motor vehicle fuel oxygenate since it reduces harmful emissions due to gasoline combustion. However, significant increase in its use recent years has raised new questions related potential toxicity. In fact, although available data are somehow conflicting, there evidence that MTBE a toxic substance may have effects on both animals and humans an unresolved problem role played by metabolites, especially alcohol (TBA), determining...
Abstract In humans, the thymus is primary lymphoid organ able to support development of T cells through its three-dimensional (3D) organization thymic stromal cells. Since a remarkable number similarities are shared between epithelial (TECs) and skin-derived keratinocytes fibroblasts, in this study we used human seeded with fibroblasts on 3D poly ε-caprolactone scaffold evaluate their ability replace TECs supporting T-cell differentiation from haematopoietic stem (HSCs). We observed that...
Cell cycle progression in eukaryotic cells is regulated by a family of cyclin-dependent kinases (CDKs). Cyclin E regulatory subunit CDK2 and drives from G1 to S phase. Increased expression cyclin frequent event human malignancies has been associated with poor prognosis various cancers. In this study, we evaluated the effects E-overexpression on sensitivity rat fibroblasts anticancer drugs. E-overexpressing were less sensitive doxorubicin-induced inhibition cell growth but not other...
Radiotherapy (RT) is an important therapeutic option in patients with localized prostate cancer (PC). Unfortunately, radiation treatment causes a decrease peripheral lymphocytes and, consequently, influences the patients' immune status. Our aim was to study changes blood cell subpopulations after RT and during 6 months' follow-up 2 groups of PC irradiated different techniques dose fractions curative intent. We also investigated presence correlation between modulation genitourinary or...
The γ-chain (γc) is a transducing element shared between several cytokine receptors whose alteration causes X-linked severe combined immunodeficiency. Recently, direct involvement of γc in self-sufficient growth concentration-dependent manner was described, implying relationship the amount molecule and its role cell cycle progression. In this study, we evaluate whether expression could interfere progression also malignant hematopoietic cells. Here, first report that absence expression,...
The thymus is the primary organ able to support T cell ontogeny, abrogated in FOXN1(-/-) human athymia. Although evidence indicates that animal models lymphocytes may differentiate at extrathymic sites, whether this process really thymus-independent has still be clarified. In an athymic fetus, which we previously described a total blockage of CD4(+) and partial CD8(+) development, investigated intestine could play role as site T-lymphopoiesis humans. We document presence few extrathymically...
Abstract A 30–year–old female, with no prior history of heart disease sought medical treatment for increasing shortness breath, oedema in the lower limbs, abdominal enlargement from seven days. She had was adopted, a smoker, use illicit drugs. Her rate 90 per minute, she bilateral pitting to mid–shin, her blood pressure 100/70mm Hg, there were signs jugular venous hypertension, pulmonary and cardiac auscultations normal. ascites liver palpable 3cm below right costal margin. ECG shown sinus...