A5076034197- Cyclopropane Reaction Mechanisms
- Synthetic Organic Chemistry Methods
- Organometallic Complex Synthesis and Catalysis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Catalytic C–H Functionalization Methods
- Asymmetric Synthesis and Catalysis
- Radical Photochemical Reactions
- Asymmetric Hydrogenation and Catalysis
- Epigenetics and DNA Methylation
- Catalytic Cross-Coupling Reactions
- Prostate Cancer Treatment and Research
- Urological Disorders and Treatments
- Glutathione Transferases and Polymorphisms
- Oxidative Organic Chemistry Reactions
- Protein Structure and Dynamics
- Additive Manufacturing and 3D Printing Technologies
- Photopolymerization techniques and applications
- Cancer-related gene regulation
- 3D Printing in Biomedical Research
- Heat shock proteins research
- Sulfur-Based Synthesis Techniques
- Mycobacterium research and diagnosis
- Molecular Biology Techniques and Applications
- Catalytic Alkyne Reactions
Scripps (United States)
2023-2024
Scripps Institution of Oceanography
2023-2024
University of Modena and Reggio Emilia
2024
Torrey Pines Institute For Molecular Studies
2024
Stockholm University
2019-2021
University of Milan
2021
Ospedale G.B. Morgagni - L.Pierantoni
2016-2018
The Kolbe reaction forms carbon-carbon bonds through electrochemical decarboxylative coupling. Despite more than a century of study, the has seen limited applications owing to extremely poor chemoselectivity and reliance on precious metal electrodes. In this work, we present simple solution long-standing challenge: Switching potential waveform from classical direct current rapid alternating polarity renders various functional groups compatible enables sustainable carbon-based electrodes...
Asymmetric cyclopropane synthesis currently requires bespoke strategies, methods, substrates, and reagents, even when targeting similar compounds. This approach slows down discovery limits available chemical space. Introduced herein is a practical versatile diazocompound its performance in the first unified asymmetric of functionalized cyclopropanes. The redox-active leaving group this reagent enhances reactivity selectivity geminal carbene transfer. effect allowed cyclopropanation various...
GSTP1 belongs to the GSTs family, a group of enzymes involved in detoxification exogenous substances and it also plays an important role cell cycle regulation. Its dysregulation correlates with large variety tumors, particular prostate cancer. We investigated methylation status specific PCR (MS-PCR) cancer (PCa) benign tissue 56 prostatectomies. performed immunohistochemistry (IHC) so as correlate gene silencing. appears methylated PCa not healthy tissue; IHC confirmed that leads protein...
Chiral cis-cyclopropanes are strained rigid analogues of alkyl chains, whose study and application limited by their difficult synthesis. A modular approach from olefin materials is enabled the discovery electron donor–acceptor (EDA) interaction between 2-substituted benzothiazolines N-hydroxyphthalimide esters. These complexes activated visible light without photocatalysts, benzothiazoline reagent plays a triple role as photoreductant, stereoselective hydrogen-atom donor, Brønsted acid....
In the molecular era, proper archival conditions within pathology laboratories are crucial, especially for formalin-fixed paraffin-embedded (FFPE) tissue specimens retrieved years after original diagnosis. Indeed, improper preservation can impact integrity of nucleic acids and protein antigens. This study evaluates quality status stored FFPE blocks using multilevel omics approaches. from 45 Non-Small Cell Lung Carcinoma (NSCLC) cases were analyzed. The collected six different archives across...
Abstract Asymmetric cyclopropane synthesis currently requires bespoke strategies, methods, substrates, and reagents, even when targeting similar compounds. This approach slows down discovery limits available chemical space. Introduced herein is a practical versatile diazocompound its performance in the first unified asymmetric of functionalized cyclopropanes. The redox‐active leaving group this reagent enhances reactivity selectivity geminal carbene transfer. effect allowed cyclopropanation...
Epigenetic silencing mediated by CpG island methylation is a common feature of many cancers. Characterizing aberrant DNA changes associated with prostate carcinogenesis could potentially identify tumour-specific pattern, facilitating the early diagnosis cancer. The objective study was to assess status 40 tumour suppressor genes in cancer and healthy prostatic tissues.We used specific-multiplex ligation probe amplification (MS-MLPA) assay two independent case series (training validation set)....
A combined experimental-computational approach has been used to study the cyclopropanation reaction of
Abstract Hydrogels are soft materials widely used as a substrate or matrix for cell culture to mimic the physicochemical, structural, and mechanical properties of cell's native microenvironment. Recently, growing body evidence has shown that topography is key determinant behavior. These studies, however, mostly rely on use hard elastomeric materials, particularly introducing in hydrogels technically challenging, labor intensive, often does not provide flexible design space. Here, new...
Asymmetric cyclopropane synthesis currently requires bespoke strategies, methods, substrates and reagents, even when targeting similar compounds. This limits the speed chemical space available for discovery campaigns. Here we introduce a practical versatile diazocompound, demonstrate its performance in first unified asymmetric of functionalized cyclopropanes. We found that redox-active leaving group this reagent enhances reactivity selectivity geminal carbene transfer. effect enabled...
Asymmetric cyclopropane synthesis currently requires bespoke strategies, methods, substrates and reagents, even when targeting similar compounds. This limits the speed chemical space available for discovery campaigns. Here we introduce a practical versatile diazocompound, demonstrate its performance in first unified asymmetric of functionalized cyclopropanes. We found that redox-active leaving group this reagent enhances reactivity selectivity geminal carbene transfer. effect enabled...
Der Aufbau eines Kohlenstoff-Stereozentrums in einer “Carbon City” der Zukunft wird illustriert, diese Bausteine einheitlichen und programmierbaren Weise zusammengefügt werden. Das Prinzip ist ähnlich wie beim gewöhnlichen Städtebau, wo mit wenigen allgemeinen Werkzeugen vielzählige Architekturen entstehen. Wie A. Mendoza et al. ihrer Zuschrift auf S. 5991 ff. zeigen, kann eine einzelne Strategie den von Cyclopropan-Stereozentren unterschiedlicher Funktionalität (farbige Atome Illustration)...
Chiral cis-cyclopropanes are strained rigid analogs of alkyl chains, whose study and application is still limited by their difficult synthesis. A modular approach for the synthesis this challenging structures from abundant olefins enabled discovery electron donor-acceptor (EDA) interaction between 2-substituted benzothiazolines N-hydroxyphtalimide esters. These complexes activated visible light without photocatalysts. In system, benzothiazoline reagent plays a triple role as photoreductant,...