A5003737863- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Monoclonal and Polyclonal Antibodies Research
- CAR-T cell therapy research
- CNS Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Genetic factors in colorectal cancer
- Viral-associated cancers and disorders
- Autoimmune and Inflammatory Disorders Research
- Colorectal Cancer Screening and Detection
- Blood groups and transfusion
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Radiopharmaceutical Chemistry and Applications
- Acute Lymphoblastic Leukemia research
- Lung Cancer Treatments and Mutations
- Chronic Myeloid Leukemia Treatments
- Neonatal Health and Biochemistry
- Brain Metastases and Treatment
- Nanofabrication and Lithography Techniques
- Multiple and Secondary Primary Cancers
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Glioma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Microfluidic and Bio-sensing Technologies
University of British Columbia
2020-2024
Spinal Cord Injury BC
2021-2024
Research Canada
2024
Shandong University
2021
Shandong Provincial Hospital
2021
Al-Sabah Hospital
2020-2021
Princess Margaret Cancer Centre
2018
University Health Network
2018
Cancer Research UK Manchester Institute
2008-2013
University of Manchester
2008-2013
Lynch syndrome or hereditary non‐polyposis colorectal cancer is caused by mutations of DNA mismatch repair (MMR) genes. The extracolonic tumour spectrum includes endometrial, ovarian, gastric, small bowel, pancreatic, hepatobiliary, brain, and urothelial neoplasms. Families were referred on the basis clinical criteria. Tumour immunohistochemistry microsatellite testing performed. Appropriate patients underwent sequencing relevant exons MMR Proven obligate mutation carriers first‐degree...
mAbs are becoming increasingly utilized in the treatment of lymphoid disorders. Although Fc-FcgammaR interactions thought to account for much their therapeutic effect, this does not explain why certain mAb specificities more potent than others. An additional effector mechanism underlying action some is direct induction cell death. Previously, we demonstrated that CD20-specific (which termed type II mAbs) evoke a nonapoptotic mode death appears be linked with homotypic adhesion. Here, reveal...
Hereditary non‐polyposis colorectal cancer (HNPCC) is an autosomal dominant condition caused by inactivating mutations of DNA mismatch repair (MMR) genes. An accurate estimation risk for mutation carriers essential counselling and rationalizing screening programmes. Families were referred on the basis clinical criteria. Tumour immunohistochemistry microsatellite testing performed. Appropriate patients underwent sequencing all relevant exons MMR Proven obligate first‐degree relatives (FDRs)...
Hemophagocytic lymphohistiocytosis (HLH) is a cytokine storm syndrome associated with mortality rates of up to 88%. Standard therapy high-dose glucocorticoids and etoposide used in adults extrapolated from pediatric trials, significant toxicity older patients those poor performance status. The JAK1/2 inhibitor ruxolitinib has recently gained attention as treatment option for HLH due its broad cytokine-modulating abilities safety profile. Herein we report our center's experience using the...
Molecular characterization of high-grade B-cell lymphoma, not otherwise specified (HGBCL-NOS), is hindered by its rarity, evolving definition, and poor diagnostic reproducibility. To address this challenge, we analyzed 92 HGBCL-NOS tumors collected across Lymphoma/Leukemia Profiling Project sites. Leveraging comparison cohorts diffuse large lymphoma (DLBCL-NOS) Burkitt (BL), molecular frameworks described in these entities, our analysis revealed a heterogenous landscape, reminiscent...
Abstract Background ABO blood groups have been linked to susceptibility infection with certain microorganisms, including coronaviruses. We examined the relationship between group and clinical outcomes in individuals infected severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) compared their distribution general population. Methods At inception of pandemic, all testing positive for SARS‐CoV‐2 Kuwait were admitted one designated coronavirus disease 2019 (COVID‐19) hospital enrolled a...
Although next-generation sequencing (NGS) has helped characterize the complex genomic landscape of myeloid malignancies, its clinical utility remains undefined. This resulted in variable funding for NGS testing, limiting accessibility. At our center, targeted (TAR-SEQ) using a 54-gene panel is offered to all new patients referred as part prospective observational study. Here, we evaluated diagnostic, prognostic, and potential therapeutic grade TAR-SEQ routine workflow 179 with...
High-grade B-cell lymphoma with MYC and BCL2 rearrangements (HGBCL-DH-BCL2), or 'double-hit lymphoma,' has been associated a high risk of central nervous system (CNS) relapse. However, historic estimates are impacted by selection bias. We report CNS relapse rates HGBCL-DH-BCL2 from population-based cohort complete fluorescence in situ hybridization testing, as well diffuse large morphology (DLBCL) tumors expressing the dark-zone gene expression signature (DZsig), which was originally derived...
Composite lymphoma (CL) is the coexistence of two or more distinct subtypes in a single biopsy, whereas discordant (DL) represents their occurrence at different anatomical sites. CL and DL were historically considered rare, but recent study showed that 12.9% all newly diagnosed diffuse large B-cell lymphomas (DLBCL) are CL/DL with concurrent indolent component.1 may comprise entities share clonally related ancestor represent 2 independent, unrelated tumors.2 Classically, was shown to consist...