A5106277732- Planetary Science and Exploration
- Astro and Planetary Science
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Metal complexes synthesis and properties
- Photodynamic Therapy Research Studies
- Semiconductor Lasers and Optical Devices
- Semiconductor Quantum Structures and Devices
- Photonic and Optical Devices
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- RNA Research and Splicing
- Healthcare Systems and Public Health
- Laser Applications in Dentistry and Medicine
- Human Health and Disease
- Laser Design and Applications
- Organometallic Compounds Synthesis and Characterization
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Biological Evaluation
- Lanthanide and Transition Metal Complexes
- Crystal structures of chemical compounds
- Nanoplatforms for cancer theranostics
- Porphyrin and Phthalocyanine Chemistry
- Photonic Crystals and Applications
- Space Exploration and Technology
Polyus Research Institute of M.F.Stelmakh (Russia)
2011-2024
Federal Medical-Biological Agency
2018-2022
Institute of Geology and Nature Management, Far Eastern Branch of the Russian Academy of Sciences
2006-2022
Central Scientific Research Institute of Traumatology and Orthopedics
2003-2022
V.I. Vernadsky Institute of Geochemistry and Analytical Chemistry
2021-2022
Russian Academy of Sciences
2005-2021
V.I.Shumakov Federal Research Center of Transplantology and Artificial Organs
2018-2021
St Petersburg University
2009-2020
Federal State Budgetary Institution Russian Scientific Center of Roentgenoradiology
2019
Ministry of Health of the Russian Federation
2019
mAbs are becoming increasingly utilized in the treatment of lymphoid disorders. Although Fc-FcgammaR interactions thought to account for much their therapeutic effect, this does not explain why certain mAb specificities more potent than others. An additional effector mechanism underlying action some is direct induction cell death. Previously, we demonstrated that CD20-specific (which termed type II mAbs) evoke a nonapoptotic mode death appears be linked with homotypic adhesion. Here, reveal...
p53 mutant tumour cells respond to genotoxic insults by bypassing G1 arrest and halting in G2. Following release from G2 they undergo mitotic catastrophe, whereby cycling is suppressed, delayed apoptosis begins endopolyploid are produced. The ability of these participate the restitution process controversial. To facilitate recovery, must repair extensive DNA damage induced. its resolution were studied observing kinetics gamma-H2AX foci formation comet assay analysis. Subsequently,...
Recent findings including computerised live imaging suggest that polyploidy cells transiently emerging after severe genotoxic stress (and named 'endopolyploid cells') may have a role in tumour regrowth anti-cancer treatment. Until now, mostly the factors enabling metaphase were studied them. Here we investigate mitotic activities and of Aurora-B, view potential depolyploidisation these cells, because Aurora-B kinase is responsible for coordination completion mitosis. We observed...
The geometric and electronic properties of supported Pt particles have been altered by modifying the ionicity (acid base properties) Al2O3 support via sol−gel method. Si modifier resulted in most acidic Cs basic support. Application new Delta XANES technique shows that, above 373K vacuum, surface is covered with hydrogen chemisorbed an atop site for dispersed on Cl−Al2O3 mostly n-fold sites a Rb−Al2O3. Further, FTIR data significant bridged CO coverage Rb−Al2O3 case but not Cl−Al2O3. At low...
Reverse‐phase HPLC was used to fractionate 40S ribosomal proteins from human placenta. Application of a C 4 , reverse‐phase column allowed us obtain 27 well‐resolved peaks. The protein composition each chromatographic fraction established by two‐dimensional polyacrylamide gel electrophoresis and N‐terminal sequencing. N‐terminally blocked were cleaved with endoproteinase Lys‐C, suitable peptides sequenced. All sequences compared those available data bases. This identify all the subunit in...
Effect of ethylene and propylene oxide tri-block copolymers (Pluronics) on the photocatalytic activity tree porphyrins differing by their hydrophobicity was studied. It shown that Pluronics induce considerable increase in tetraphenylporphyrin, hematoporphyrin disodium salt (Dimegine) relatively hydrophilic N-methyl-bis-glucamine chlorine e6 (Photoditazine) reaction photooxidation tryptophan water solution. This effect maximal for F127 P85 with intermediate hydrophobicity, while more F68...
Site-directed spin labeling (SDSL) is widely applied for structural studies of biopolymers by electron paramagnetic resonance (EPR). However, SDSL long RNA sequences still remains a challenging task. Here, we propose novel approach potentially suitable natural RNAs, which based on the attachment linker containing an aliphatic amino group to target nucleotide residue followed selective coupling label this group. Such can be attached desired via sequence-specific reaction with derivatives...
Fifty-three patients with single, multiple and/or multi-organ hydatid cysts were treated mebendazole, in varying dosages (30-70 mg/kg.day) and over periods (6-24 months). Treatment failure was recorded if the mebendazole had no apparent effect on cyst morphology (monitored by radiology, ultrasonography computed tomography) or only a parasitostatic (characterized mixed transitory, hypo- hyper-echoic changes lesions). Cure indicated parasitocidal totally echogenic picture, increased density of...
The creation and application of new low-toxic photosensitizers for the luminescence diagnostics cancer are considered. weakly generate singlet oxygen, exhibit developed luminescence, retain tumor-tropic properties therapeutic photosensitizers. Twenty one ytterbium complexes porphyrin compounds that differ by substituents at periphery ring synthesized. absorption spectra decay curves these substances studied. primary toxicological pharmacokinetic investigations performed most promising in...
The eukaryotic ribosomal protein S26e (rpS26e) lacking eubacterial counterparts is a key component of the binding site mRNA region 5′ codon positioned at exit site. Here, we determined rpS26e oligopeptide neighboring on human 80S ribosome using analogues bearing perfluorophenyl azide-derivatized nucleotides designed locations. was cross-linked to in specific complexes, which derivatized nucleotide located positions −3 −9. Digestion with various proteolytic agents followed by identification...
In a large-scale Bulgarian study, 122 patients with abdominal and/or lung echinococcosis were randomly selected for treatment albendazole or mebendazole. The main aims to evaluate the effect of each drug on hydatid cysts, follow changes in cyst morphology during and after treatment, determine how quickly produced first, detectable, degenerative cysts. Follow-up was based periodic ultrasonography, chest radiography computed tomography. cysts categorised as small (<5 cm diameter) large. As had...
Temperature-dependent transient processes initiated by a direct photogeneration of singlet oxygen in suspensions human erythrocytes and solutions serum albumin are studied. The appear as anomalous jumps the temperature dependences deformability coefficient refractive index extracellular medium protein solution. In regions jumps, cells proteins transfer to metastable state lower activity, but they can be isothermally photoreactivated. Simultaneously, reversible rearrangement aqueous phase...
Recently, photodynamic therapy (PDT) has been used for the treatment of festering wounds and trophic ulcers. An important advantage PDT is its ability to affect bacterial cultures that are resistant antibiotics. However use alone does not usually guarantee a stable antiseptic effect cannot prevent an external infection burns. In this work attention focused on healing extensive soft tissues with combined laser (LT) treatment. At first stage process (for example spacious purulent area more...