A5010378837- Ion Channels and Receptors
- Solar and Space Plasma Dynamics
- Nuclear Physics and Applications
- Plant Stress Responses and Tolerance
- Astro and Planetary Science
- Geophysics and Gravity Measurements
- Radiation Detection and Scintillator Technologies
- Ion channel regulation and function
- Ionosphere and magnetosphere dynamics
- Biochemical Analysis and Sensing Techniques
- Gyrotron and Vacuum Electronics Research
- Geomagnetism and Paleomagnetism Studies
- Photocathodes and Microchannel Plates
- Particle accelerators and beam dynamics
- RNA regulation and disease
- Meteorological Phenomena and Simulations
- Calcium signaling and nucleotide metabolism
- Cannabis and Cannabinoid Research
- Quantum optics and atomic interactions
- Magnetic and Electromagnetic Effects
- Railway Systems and Energy Efficiency
- Surfactants and Colloidal Systems
- Electric Power Systems and Control
- Economic and Technological Systems Analysis
- Lipid Membrane Structure and Behavior
Institute of Bioorganic Chemistry
2019-2024
Moscow Engineering Physics Institute
2011-2023
Irkutsk State Transport University
2023
National Research University Higher School of Economics
2019
Moscow State University
2010
Abstract Calcium-selective oncochannel TRPV6 is the major driver of cell proliferation in human cancers. While significant effort has been invested development synthetic inhibitors, natural channel blockers have largely neglected. Here we report structure complex with plant-derived phytoestrogen genistein, extracted from Styphnolobium japonicum , that was shown to inhibit invasion and metastasis cancer clinical trials. Despite pharmacological value, molecular mechanism inhibition by...
Abstract Structural biology is solving an ever-increasing number of snapshots ion channel conformational ensembles. Deciphering mechanisms, however, requires understanding the ensemble dynamics beyond static structures. Here, we present a molecular modeling-based approach characterizing structural intermediates, or their “dynamic portraits”, by assessing water and conductivity along with detailed evaluation pore hydrophobicity residue packing. We illustrate power this analyzing structures...
Abstract The calcium-selective oncochannel TRPV6 is an important driver of cell proliferation in human cancers. Despite increasing interest pharmacological research developing synthetic inhibitors TRPV6, natural compounds acting at this channel have been largely neglected. On the other hand, pharmacokinetics small-molecule antagonists optimized by nature throughout evolution endows these with a medicinal potential to serve as potent and safe next-generation anti-cancer drugs. Here we report...
Solvation effects play a key role in chemical and biological processes. The microscopic properties of water near molecular surfaces are radically different from those the bulk. Furthermore, behavior confined volumes nanometer scale, including transmembrane pores ion channels, is especially nontrivial. Knowledge at level structural dynamic parameters such systems necessary to understand mechanisms channels functioning. In this work, results dynamics (MD) simulations pore selectivity filter...
The so-called "hydrophobic gating" is widely discussed as a putative mechanism to control water and ion conduction via channels. This effect can occur in narrow areas of the channels pore lined by non-polar residues. In closed state channel, such regions may spontaneously transit dehydrated block ions transport without full occlusion. open state, hydrophobic gate wide enough provide sustainable hydration conduction. Apparently, through facilitated some polar residues that assist...
PMT performances significantly change under the influence of magnetic field. Even relatively weak geomagnetic field, which typically value is about 0.5 gauss, has an appreciable effect. Gain variations with 76 mm photocathode diameter may reach 10-20% depending on spatial orientation. Therefore, it necessary to apply shields for response stability enhancement. The investigation made steel, permalloy and amorphous metallic alloy ribbon 51 diameters was carried out. Based obtained data choice...
Abstract The article presents some results of research to improve the stability rail circuits and automatic cab signaling on Railways. Signals locomotive under influence stationary harmonic random impulse noise are considered, sources which can be power lines, devices, radio frequency electromagnetic fields, electrostatic discharges, lightning traction supply networks, as well adjacent circuits. Particular attention is paid negative effects reverse current uneven magnetization rails. It...
In the article issue of transforming transport education in Russian Federation is discussed, substantiating necessity to introduce educational tracks form a young specialist since set his professional skills should forestall level current manufacturing technologies used. The strategic documents industry have been analyzed with requests identifi ed presenting specifi cs their own for operation under digital economy and at railroad. promising directions fi eld are considered. twins technology...
GRIS is a prospective experiment designed to measure hard X-rays and γ-rays of solar flares in the energy range from 50 keV 200 MeV as well neutrons > 30 MeV. This study considers results GEANT 4 simulation detectors response cosmic background radiation flare SOL2002-07-23 (X4.8). It shown that spectrometers have enough sensitivity resolution redshifts some narrow spectra, low thresholds can be lowered considerably without risk counting rate saturation during high magnitude at choice between...
The unique capabilities of the detector, based on CeBr3 crystal (very short flashing time) allow us to expand range problems solved in GRIS experiment. In addition registering solar flares that have characteristic times per second÷minute, this detector allows solving identifying and recording characteristics geophysical astrophysical events (short gamma-ray bursts - SGRB terrestial TGF) time 10μs÷1 ms. modification hardware device for these is described discussed paper.
The main aim of this research is the development and prototyping ionizing radiation detectors for diagnosis physical processes used monitoring situation at thermal or fast neutrons reactors. In article we present experimental verification applicability scintillation based on LaBr3(Ce) YAlO3(Ce). studies gamma-ray detection with several designs crystal in gas liquid are considered. It was shown that measurement range medium duration one 100 seconds 137Cs equals from 3.79·102 Bq/l to 1.08·108...
The so-called “hydrophobic gating” is widely discussed as a putative mechanism to control water and ion conduction via channels. This effect can occur in narrow areas of the channels pore lined by non-polar residues. In closed state channel, such regions may spontaneously transit dehydrated block ions transport without full occlusion. open state, hydrophobic gate wide enough provide sustainable hydration conduction. Apparently, through facilitated some polar residues that assist...