A5084831558- Catalytic C–H Functionalization Methods
- Asymmetric Hydrogenation and Catalysis
- Synthetic Organic Chemistry Methods
- Bioactive Compounds and Antitumor Agents
- Spectroscopy and Quantum Chemical Studies
- Protein Structure and Dynamics
- Asymmetric Synthesis and Catalysis
- Photoreceptor and optogenetics research
- CO2 Reduction Techniques and Catalysts
- Microbial Natural Products and Biosynthesis
- Polyoxometalates: Synthesis and Applications
- Chemical Synthesis and Analysis
- Catalytic Alkyne Reactions
- Radioactive element chemistry and processing
The University of Texas at Austin
2019-2024
Robert Bosch (Germany)
2019
University of Pennsylvania
2015
California University of Pennsylvania
2015
Philadelphia University
2015
Recently it has been suggested that the C≡N stretching vibration of a tryptophan analog, 5-cyanotryptophan, could be used as an infrared probe local environment, especially hydration status, residues in proteins. However, factors influence frequency this vibrational mode are not understood. To determine these factors, herein we carried out linear and nonlinear measurements on sidechain 3-methyl-5-cyanoindole, series protic aprotic solvents. We found while frequencies obtained solvents do...
Abstract Use of abundant feedstock pronucleophiles in catalytic carbonyl reductive coupling enhances efficiency target‐oriented synthesis. For such reactions, equally inexpensive reductants are desired or, ideally, corresponding hydrogen autotransfer processes may be enacted wherein alcohols serve dually as reductant and proelectrophile. As described this Minireview, these concepts allow reactions that traditionally require preformed organometallic reagents to conducted catalytically a...
The first total synthesis of the pentacyclic phenylnaphthacenoid type II polyketide antibiotic formicamycin H is described. A key feature involves convergent, regioselective assembly tetracyclic core via ruthenium-catalyzed α-ketol-benzocyclobutenone [4 + 2] cycloaddition. Double dehydration diol-containing cycloadduct provides an achiral enone, which upon asymmetric nucleophilic epoxidation and further manipulations delivers penultimate trichloride in enantiomerically enriched form....