A5032935506- Reproductive Biology and Fertility
- Assisted Reproductive Technology and Twin Pregnancy
- Ovarian function and disorders
- Reproductive Health and Technologies
- COVID-19 Impact on Reproduction
- Maternal and Perinatal Health Interventions
- Ectopic Pregnancy Diagnosis and Management
- Prenatal Screening and Diagnostics
- Sperm and Testicular Function
- Coenzyme Q10 studies and effects
- Reproductive Health and Contraception
- Maternal and fetal healthcare
- Mitochondrial Function and Pathology
- Pluripotent Stem Cells Research
- Reproductive System and Pregnancy
- Uterine Myomas and Treatments
- Pelvic floor disorders treatments
- Renal and related cancers
- SARS-CoV-2 and COVID-19 Research
- Endometriosis Research and Treatment
- Vaccine Coverage and Hesitancy
- Birth, Development, and Health
- Congenital Anomalies and Fetal Surgery
- Genetic and phenotypic traits in livestock
- Endometrial and Cervical Cancer Treatments
Hebrew University of Jerusalem
2008-2025
Hadassah Medical Center
2014-2024
University Medical Center
2021
Lunenfeld-Tanenbaum Research Institute
2011-2019
Mount Sinai Hospital
2015-2019
CReATe Fertility Centre
2019
Hadassah Academic College
2005-2016
University of Toronto
2011
Washington University in St. Louis
2011
Weatherford College
2009
Summary Female reproductive capacity declines dramatically in the fourth decade of life as a result an age‐related decrease oocyte quality and quantity. The primary causes aging molecular factors responsible for decreased remain elusive. Here, we show that female germ line is accompanied by mitochondrial dysfunction associated with oxidative phosphorylation reduced Adenosine tri‐phosphate ( ATP ) level. Diminished expression enzymes CoQ production, Pdss2 Coq6, was observed oocytes older...
Clinically compliant human embryonic stem cells (hESCs) should be developed in adherence to ethical standards, without risk of contamination by adventitious agents. Here we for the first time animal-component free and good manufacturing practice (GMP)-compliant hESCs. After vendor raw material qualification, derived xeno-free, GMP-grade feeders from umbilical cord tissue, utilized them within a novel, xeno-free hESC culture system. We characterized three lines regulations embryo procurement,...
What is the clinical value of Day 7 blastocysts?Ending embryo culture at 144 hours post-insemination (h.p.i.; i.e. 6 days) would involve 7.3% and 4.4% relative reductions in number patients obtaining euploid blastocysts live birth(s) (LBs), respectively.Many studies showed that are clinically valuable, although less competent than faster-growing embryos. Nevertheless, a large variability exists in: (i) definition 'Day 7'; (ii) criteria to embryos 7; (iii) setting; (iv) local regulation;...
Over the past four decades, due to cultural and social changes, women in developed world have significantly delayed childbirth. This trend is even worse for patients who attend infertility clinics. It well-known that live birth rates older than 35 are lower those younger, both naturally with assisted reproduction. Fertility decline is, part, an increase oocyte aneuploidy leads a reduced embryo quality, as well increased incidence of miscarriages defects. Here we show aging-associated...
Abstract STUDY QUESTION What are the factors associated with human blastocyst spontaneous collapse and consequences of this event? SUMMARY ANSWER Approximately 50% blastocysts collapsed, especially when non-viable, morphologically poor and/or aneuploid. WHAT IS KNOWN ALREADY Time-lapse microscopy (TLM) is a powerful tool to observe preimplantation development dynamics. Lately, artificial intelligence (AI) has been harnessed automate standardize such observations. Here, we adopted AI...
To investigate the association between Polycystic Ovary Syndrome (PCOS) and rate of embryo development, using time-lapse monitoring systems (TLM), compared to a control group women with mechanical (tubal) factor infertility. A retrospective case-control study conducted in university affiliated IVF unit. Women PCOS undergoing in-vitro fertilization (IVF) treatments those non-PCOS controls tubal infertility only. Development morphokinetic milestones were analysis covariance for time distinct...
Background The most effective strategy for prevention of ovarian and breast cancer in high-risk women is bilateral salpingo-oophorectomy. inevitable consequence the procedure early menopause with associated climacteric symptoms. Little known about nature symptoms who undergo risk-reducing salpingo-oophorectomy.Objectives To compare nature, frequency, severity, duration, overall effects a group underwent preventive salpingo-oophorectomy as compared to experienced natural menopause.Methods...
In in vitro fertilization (IVF) treatments, early identification of embryos with high implantation potential is required for shortening time to pregnancy while avoiding clinical complications the newborn and mother caused by multiple pregnancies. Current classification tools are based on morphological morphokinetic parameters that manually annotated using time‐lapse video files. However, manual annotation introduces interobserver intraobserver variability provides a discrete representation...
Abstract In vitro fertilization is typically associated with high failure rates per transfer, leading to an acute need for the identification of embryos developmental potential. Current methods are tailored specific times after fertilization, often require expert inspection, and have low predictive power. Automatic challenged by ambiguous labels, clinical heterogeneity, inability utilize multiple points. this work, we propose a novel method that trains classifier conditioned on time since...
First trimester miscarriage is a major concern in IVF-ET treatments, accounting for one out of nine clinical pregnancies and up to three recognized pregnancies. To develop machine learning classifier predicting the risk cleavage-stage embryos undergo first based on time-lapse images preimplantation development.
Our objective was to design an automated deep learning model that extracts the morphokinetic events of embryos were recorded by time-lapse incubators. Using annotation, we set out characterize temporal heterogeneity preimplantation development across a large number embryos.
Data collection regarding the effects of COVID-19 on reproduction is ongoing. This study examined effect IVF cycle parameters and early pregnancy outcomes. It included two arms: first compared non-exposed cycles to post-SARS-CoV-2 cycles. Sperm were also compared. The second, prospective arm outcomes among patients who contracted during those did not. None vaccinated against SARS-CoV-2. 60 treatment women with confirmed COVID-19, (either same patient before exposure or matched patients). not...
Abstract Blastocyst selection is primarily based on morphological scoring systems and morphokinetic data. These methods involve subjective grading time-consuming techniques. Artificial intelligence allows for objective quick blastocyst selection. In this study, 608 blastocysts were selected transfer using morphokinetics Gardner criteria. Retrospectively, morphometric parameters of size, inner cell mass (ICM) ICM-to-blastocyst size ratio, ICM shape automatically measured by a semantic...
To improve patient consultation before external cephalic version (ECV) attempt at term by defining prognostic parameters for the success of procedure.This was a prospective observational study set in university teaching hospital. We prospectively collected demographic and obstetric data from 603 ECV attempts our center period between January 1997 June 2005. Analysis performed stepwise logistic regression parameters. The main outcome measure attempt.Success rates were 72.3% 46.1% multiparas...
Abstract Objective To investigate the possible impact of Pfizer-BioNTech’s mRNA BNT162b2 COVID-19 vaccine on women’s fertility. Methods A retrospective single-center study examining IVF treatment parameters and pregnancies before after their vaccination between February May 2021. Each woman served as a self-control vaccination. Additionally, in order to neutralize effect sperm fertilization, only Intracytoplasmic Sperm Injection (ICSI) patients who were currently being treated with an ICSI...
Our objective was to evaluate the effectiveness of adhesive glue in repairing first degree perineal tears. We conducted a noninferiority prospective, randomized, controlled trial comparing with traditional suturing. Each case evaluated immediately after birth and puerperium. The two-sample t-test Mann-Whitney nonparametric test were applied compare quantitative variables between treatment groups. chi-squared Fisher's exact used assess association qualitative variables. A total 102 women...
It has been shown - mostly in animal models that circadian clock genes are expressed granulosa cells and corpora luteum might be essential for the ovulatory process steroidogenesis.We sought to investigate which exist human whether their expression activity decrease during aging of ovary.Human luteinized were isolated from young (age 18-33) older 39-45) patients who underwent in-vitro fertilization treatment. Levels measured these 36 h after chorionic gonadotropin stimulation.Human...