A5043730105- Treatment of Major Depression
- Anesthesia and Neurotoxicity Research
- Stress Responses and Cortisol
- Enhanced Recovery After Surgery
- Tryptophan and brain disorders
- Anesthesia and Sedative Agents
- Neuroscience and Neuropharmacology Research
- Health and Wellbeing Research
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer, Hypoxia, and Metabolism
- Bone and Joint Diseases
- Antioxidants, Aging, Portulaca oleracea
- Physical Activity and Health
- Bone Metabolism and Diseases
- Lung Cancer Treatments and Mutations
- Transcranial Magnetic Stimulation Studies
- Music Therapy and Health
- Infection Control and Ventilation
- Cancer, Lipids, and Metabolism
- Traditional Chinese Medicine Analysis
- Education, Safety, and Science Studies
- Herbal Medicine Research Studies
- RNA regulation and disease
- Genetic Associations and Epidemiology
- Respiratory and Cough-Related Research
The Affiliated Yongchuan Hospital of Chongqing Medical University
2012-2025
Chongqing Medical University
2012-2025
Heilongjiang University of Chinese Medicine
2021-2025
Tianjin University
2025
Chengdu Fifth People's Hospital
2024
Chengdu University
2024
Shanghai Jiao Tong University
2024
Renji Hospital
2024
First Hospital of Jilin University
2024
Jilin University
2024
Sleep deprivation adversely affects the digestive system. Multiple studies have suggested sleep and oxidative stress are closely related. Autophagy can be triggered by as a self-defense strategy to promote survival. In this study, we investigated effects of on liver functions, stress, concomitant hepatocyte autophagy, well associated pathways. Enzymatic nonenzymatic biochemical markers in serum were used assess hepatic function damage. To evaluate occurrence expression autophagy-related...
To explore the therapeutic effect of polygonum cuspidatum glycoside on steroid-induced osteonecrosis femoral head(SONFH) in rats and its potential mechanism protecting bone tissue by regulating Janus kinase 2/signal transducer activator transcription 3 signaling pathway(JAK2/STAT3). Fifty male SD were randomly divided into control group, model low-dose group (polygonum glycoside-L), high-dose glycoside-H), glycoside-H+Colivelin (JAK2/STAT3 pathway activator) group. SONFH was induced...
BACKGROUND: Low health literacy (HL) adversely affects medical adherence and outcomes in patients with chronic diseases. However, the association between HL enhanced recovery after surgery (ERAS) postoperative has not been investigated undergoing colorectal surgery. METHODS: The data of all from a single academic institution who underwent on an ERAS pathway January 2019 to July 2020 were prospectively collected. levels assessed using Brief Health Literacy Screen (BHLS), proven tool that was...
Background Whether sarcopenic obesity had unfavorable effect on survival of peritoneal dialysis (PD) patients is unknown. We aimed to investigate the association between and in PD patients. Methods This was a prospective observational study. Eligible from November 2016 December 2017 were enrolled followed until August 31, 2023. Sarcopenia defined following recommendations Asian Working Group for (AWGS) as low appendicular skeletal muscle mass index (ASMI) handgrip strength (HGS). Obesity...
Although paclitaxel is a promising frontline chemotherapy agent for various malignancies, the clinical applications have been restricted by side effects, drug resistance, and cancer metastasis. The combination of other agents could be strategies against malignant tumor, which enhances antitumor effect through synergistic reduces required concentrations, also suppresses tumorigenesis in multiple ways. In this study, we found that luteolin, natural flavonoid compound, combined with low‐dose...
Chronic heavy drinking causes ethanol-induced osteoporosis (EIO). The present study aimed to explore the role of GM in EIO.A rat EIO model was established by chronic ethanol intake. Taking antibiotic application as matched group dysbacteriosis, an integrated 16S rRNA sequencing and liquid chromatography-tandem mass spectrometry-based metabolomics serum faeces were applied association differential metabolic phenotypes screen out candidate metabolites detrimental ossification. colon organoids...
Irinotecan (CPT-11) is used for therapy of various cancers. However, it has several serious adverse reactions such as diarrhea which caused by SN-38, the active form CPT-11. This study aimed to evaluate effectiveness Jiawei xianglian decoction (JWXLD), been widely treatment in China. In this study, a mouse model with delayed was generated Real-time PCR and enzyme-linked immunosorbent assay (ELISA) were performed explore intestinal microflora inflammatory cytokine. Hematoxylin eosin (H&E)...
Enhanced recovery after surgery (ERAS) pathways have been shown to improve clinical outcomes surgery. Considering the importance of patient experience for patients with benign surgery, this study evaluated whether improved compliance ERAS protocol modified gynecological which recommended by Society is associated better and experience, determine influence each element on patients' outcome hysterectomy. A prospective observational was performed women who underwent hysterectomy between 2019...
Observational studies have reported a close relationship between post-traumatic stress disorder (PTSD) and neurological disorders, but the existence of causal link remains uncertain. The aim this study is to investigate these relationships potential mediators via Mendelian randomization (MR) analysis. We sourced pooled data for genome-wide association (GWAS) PTSD (n = 1,222,882) from psychiatric genomics consortium. Summary-level eight traits were derived large-scale GWASs. Genetic...
Radiation-induced lung injury (RILI) frequently occurs in patients with thoracic malignancies. In response to radiation, alveolar epithelial cells (AEC) undergo epithelial-mesenchymal transition (EMT) and contribute the pathogenesis of RILI. Insulin-like growth factor binding protein 7 (IGFBP7) is reported as a downstream mediator transforming factor-β1 (TGF-β1) pathway, which plays crucial role radiation-induced EMT. present study, levels IGFBP7 TGF-β1 were simultaneously increased...
This study aimed at investigating the effects of propofol on expression hippocampal neuronal nitric oxide synthase (nNOS) and carboxy-terminal PDZ ligand nNOS (CAPON) in stressed rats after electroconvulsive shock (ECS).Sprague-Dawley were repeatedly for 28 days to establish a model. Forty randomly divided into 4 groups (n = 10 each group): group (unapplied group), (applied with intraperitoneal injection 80 mg/kg 7 days), ECS normal saline 8 mL/kg), or + mg/kg). Sucrose preference test,...
Steroid-induced osteonecrosis of the femoral head (SIONFH) is a frequent orthopedic disease caused by long-term or high-dose administration corticosteroids. Tanshinone I (TsI), flavonoid compound isolated from Salvia miltiorrhiza Bunge, has been reported to inhibit osteoclastic differentiation in vitro. This study aimed investigate whether TsI can ameliorate SIONFH. Herein, SIONFH was induced intraperitoneal injection 20 μg/kg lipopolysaccharide every 24 h for 2 days, followed an...
The present study examines the microstructure of rapidly solidified ribbons an Mg–9.0 wt% Al–1.0 Zn–4.0 Sn alloy. XRD and transmission electron microscopy (TEM), including high-resolution (HRTEM), confirmed that consist α-Mg, γ-Mg17Al12 β-Mg2Sn phases. predominant fraction phase reveals intergranular texture morphologies with Burgers OR. minor γ exists in short-lath morphology a typical grain size 30 nm, its orientation relationship matrix is also relationship. particle spherical 40 form , .
To explore the neuroprotective effects of Shaoyao Gancao decoction (SGD) against excitatory damage in PC12 cells and role Src-NR2-nNOS pathway mediation by SGD regulating γ-aminobutyric acid (GABA)-glutamate (Glu) homeostasis. N-Methyl-d-aspartic (NMDA) was used to establish a cell excitability injury model. investigate effect SGD, Cell Counting Kit-8 (CCK-8) assay determine viability, Annexin V/Propidium Iodide (Annexin V/PI) double staining apoptosis, Ca2+ concentration observed using...
Aspirin-exacerbated respiratory disease (AERD) is a clinical syndrome characterized by chronic rhinosinusitis with nasal polyps, asthma and the development of significant airway symptoms following ingestion aspirin other nonsteroid anti-inflammatory drugs (NSAIDs). At present, challenge gold standard for diagnosis. Aspirin desensitization therapy after (ATAD) one classical therapies. This paper described application ATAD in AERD provided reference comprehensive treatment AERD.
Neprilysin (NEP), a zinc-dependent membrane-bound metallopeptidase, regulates various bioactive peptides, particularly in kidneys, vascular endothelium, and the central nervous system. NEP’s involvement metabolizing natriuretic insulin, enkephalins makes it promising target for treating cardiovascular Alzheimer’s diseases. Several NEP inhibitors, such as sacubitril omapatrilat, have been approved clinical use, which inhibit activity to prolong bioactivity of beneficial thereby exerting...
A growing number of studies have demonstrated that ketamine induces rapid and sustained antidepressant action. Neuronal nitric oxide synthase (nNOS) signaling has been explored for the treatment neuropsychiatric disorders decades. But effect on nNOS is poorly understood. The aim present study was to investigate in a chronic unpredictable mild stress (CUMS) model depression.Forty-eight rats were randomly divided into four groups: control group healthy (group C), treated with 10 mg/kg 3 days...
Objectives: This study aimed to evaluate the level and factors affecting perioperative exercise intention in China. Design: was a cross-sectional survey Southwest Methods: Four hundred ninety nine participants were randomly sampled eight medical centers from November 23, 2020 27, 2020. The included sociodemographic information 24-item modified questionnaire, which attitude toward daily exercise, perception of social support intention. A multivariable linear regression model used effect...
Abstract Background: Rhizoma Drynariae (RD), a traditional Chinese medicine with pleiotropic biological activities, exerts protective effect against age-related osteoporosis. Osteoporosis is serious clinical problem and characterized by the deterioration in bone volume strength, mainly due to dysfunction of marrow stromal cells (BMSCs). However, it remains unclear whether RD-containing serum regulates osteogenic differentiation BMSCs via Wnt/β-catenin signaling pathway. Methods: The effects...