A5101641241- Traditional Chinese Medicine Analysis
- Pharmacological Effects of Natural Compounds
- Cardiac electrophysiology and arrhythmias
- Bone and Joint Diseases
- Bone Metabolism and Diseases
- Ion channel regulation and function
- Esophageal Cancer Research and Treatment
- Liver Disease Diagnosis and Treatment
- Inflammatory mediators and NSAID effects
- Drug Transport and Resistance Mechanisms
- Bone health and treatments
- Infant Nutrition and Health
- Bariatric Surgery and Outcomes
- Autoimmune and Inflammatory Disorders
- Infant Health and Development
- Ginseng Biological Effects and Applications
- Cancer Mechanisms and Therapy
- Acute Myeloid Leukemia Research
- Healthcare and Venom Research
- Epigenetics and DNA Methylation
- Nanocluster Synthesis and Applications
- Nutrition and Health in Aging
- Cancer Immunotherapy and Biomarkers
- Phytochemical and Pharmacological Studies
- Hematopoietic Stem Cell Transplantation
Heilongjiang University of Chinese Medicine
2017-2025
Nanjing Normal University
2019-2025
Kagawa University
2024
Wenzhou Medical University
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
Wangjing Hospital of China Academy of Chinese Medical Sciences
2021
Soochow University
2020
Capital Medical University
2019
University of California, Irvine Medical Center
2019
Weifang Maternity and Child Care Hospital
2019
Recent studies have suggested that inositol-1,4,5-trisphosphate-receptor (IP 3 R)–mediated Ca 2+ release plays an important role in the modulation of excitation–contraction coupling (ECC) atrial tissue and generation arrhythmias, specifically chronic fibrillation (AF). IP R type-2 R2) is predominant isoform expressed myocytes. To determine R2 arrhythmogenesis ECC, we generated R2-deficient mice. Our results revealed endothelin-1 (ET-1) stimulation wild-type (WT) myocytes caused increase...
Abstract We tested the hypothesis that induction of cyclo-oxygenase (COX) 2 mediates some effects bone morphogenetic protein (BMP) on bone. BMP-2 induced COX-2 mRNA and prostaglandin (PG) production in cultured osteoblasts. increased luciferase activity calvarial osteoblasts from mice transgenic for a promoter-luciferase reporter construct (Pluc) MC3T3-E1 cells transfected with Pluc. Deletion analysis identified −300/−213-bp region promoter as necessary stimulation activity. Mutation...
This study aimed to investigate the underlying mechanisms of Duhuo Jisheng Decoction(DJD) in prevention and treatment knee osteoarthritis(KOA). Forty SPF New Zealand rabbits were randomly divided using SPSS 26.0 software into five groups: blank group, model low-dose DJD high-dose DJD+phosphatidylinositol 3-kinase(PI3K)/protein kinase B(Akt)/mammalian target rapamycin(mTOR) signaling pathway activator group(high-dose DJD+740Y-P group), with eight each group. Except for KOA was established...
There have been anecdotal reports that local hyperthermia was effective in the treatment of viral warts. We conducted a randomized, patient-blinded, placebo-controlled trial to test effect (44°C for 30 min day 3 consecutive days plus 2 additional weeks later) on plantar By end months, 53.57% patients (15/28) group and 11.54% (3/ 26) control were cured (P < .01). The not influenced by patient age, duration disease, or number size lesions.
Inflammatory bowel disease is associated with carcinogenesis, which limits the prognosis of patients. The local expression proteinases and proteinase-activated receptor 1 (PAR
Articular cartilage degradation is a main feature of osteoarthritis (OA). The effects Danshen, traditional Chinese herb, in mitigating damage have been reported before. This study was conducted to investigate the Danshen on injuries OA. Rabbit OA models were established by surgical destabilization medial meniscus and anterior posterior cruciate ligaments left knee joint. Injection into articular cavity attenuated destruction vivo. levels phosphorylated Janus kinase 2 (JAK2) signal transducer...
The phase I metabolizing enzyme and II play vital roles in carcinogenesis, but little is known about the changes of their activities patients with hepatocellular carcinoma (HCC) secondary to chronic hepatitis B virus (HBV) infection. In this study phenacetin, a probe drug (1 g for men 0.85 women orally), was applied detection sulfotransferase 1A1 (SULT1A1) cytochrome P4501A2 (CYP1A2) 82 healthy participants 148 HCC, 106 cirrhosis, 41 patients. addition, prospective cohort susceptibility HCC...
Esophageal cancer responds poorly to conventional radiotherapy, chemotherapy, and/or surgery. Immunotherapy works by boosting the body's immune system, and preoperative immunotherapy combined with chemotherapy may increase survival rate of patients esophageal cancer. Here we further explore immunotherapy's role in treating borderline resectable (BR) squamous cell carcinoma (ESCC) combining chemotherapy.In this multicenter, randomized controlled study plus for BR ESCC, [i.e., tislelizumab...
A meta-analysis was performed to analyze the efficacy of 3% hypertonic saline (HS) in bronchiolitis. Pubmed and MEDLINE databases were searched for relevant articles. total 2 authors selected articles according inclusion criteria then data carefully extracted. Weighted mean difference (WMD) with 95% confidence interval (95% CI) values used pool continuous data, including length stay clinical severity score (CSS). Relative risk (RR) CI calculated determine association between HS re-admission....
Objective: To develop a physical- cognitive scale for assessment of frailty and compare the clinical features between new conventional Fried criteria.Methods: 1757 individuals aged 70–84 were analyzed. Participants reporting three or more phenotypes grouped as frail patients (FP) whereas others non-frail (NF). A score Hasegawa's dementia (HDS-R) higher than 21.5 classified non-cognitive impairment group (NCI) group. By combining criteria, participants manifesting positive components out six...
To investigate the effects of Chinese herbal medicine in tonifying qi and attaining hemostasis caused by metabolism drug clopidogrel as a result platelet gastric mucosa injury an ischemia-reperfusion rat model.A pharmacokinetic model was established to record parameters metabolites. Then, absorption compared with approaches using traditional (TCM) approach establishing hemostasis, pantoprazole applying these combination clopidogrel. Intragastric administration performed, all indicators were...
Steroid-induced osteonecrosis of the femoral head (SIONFH) is a frequent orthopedic disease caused by long-term or high-dose administration corticosteroids. Tanshinone I (TsI), flavonoid compound isolated from Salvia miltiorrhiza Bunge, has been reported to inhibit osteoclastic differentiation in vitro. This study aimed investigate whether TsI can ameliorate SIONFH. Herein, SIONFH was induced intraperitoneal injection 20 μg/kg lipopolysaccharide every 24 h for 2 days, followed an...
Abstract To investigate the effect and mechanism of Huogu injection (HG) on steroid-induced osteonecrosis femoral head (SONFH), we established a SONFH model in rabbits using horse serum dexamethasone (DEX) applied HG locally at hip joint. We evaluated therapeutic efficacy 4 weeks scanning electron microscopy (SEM), micro-CT, qualitative histology including H&E, Masson’s trichrome, ALP, TUNEL staining. In vitro, induced osteogenic differentiation bone marrow stromal cells (BMSCs)...
Decitabine (5-aza-2'-deoxycytidine; DAC) is a well-tolerated alternative to aggressive chemotherapy for leukemia, which induces differentiation and apoptosis of leukemic cells as DNA hypomethylating agent. The aim the present study was investigate feasibility DAC sequentially combined with reverse drug resistance. HL-60/ADR multidrug-resistant leukemia cultured in 96-well plates were pretreated 72 h; varying concentrations aclacinomycin (ACLA) then added wells, cell proliferation tested...
The clinical outcome of the advanced biliary tract cancer (BTC) is unfavorable, and mortality rate high. With local advance metastasis, median survival time less than 1 year. But this patient survived 14 months with no signs progress under treatment in our hospital. And situation stable recently. This case report can provide a template for clinicians. was appeared dull pain upper abdomen, occasionally poor defaecating. After series medical tests, diagnosed gallbladder (GBC). received...
Objective To study prevention and treatment effect of curcumin on autoimmune hepatitis (AIH) induced by concanavalin A (Con A) in mice model.Methods AIH models were established they divided into four groups：normal control group，model group，curcumin group，and cyclosporine group.The alanine aminotransferase (ALT) changes peripheral blood was detected IFCC-rate methods，and the degree inflammatory cell infiltration observed liver paraffin sections.Results The ALT values model group reached its...