A5102969293- Diabetes and associated disorders
- Pancreatic function and diabetes
- Diabetes Management and Research
- Adipokines, Inflammation, and Metabolic Diseases
- Ocular Surface and Contact Lens
- Medical Research and Treatments
- Biomarkers in Disease Mechanisms
- Peroxisome Proliferator-Activated Receptors
- Eicosanoids and Hypertension Pharmacology
- Vitamin C and Antioxidants Research
- Vestibular and auditory disorders
- Diet, Metabolism, and Disease
- Glaucoma and retinal disorders
- Cancer, Hypoxia, and Metabolism
- Traditional Chinese Medicine Studies
Second Xiangya Hospital of Central South University
2016-2022
Central South University
2016-2022
National Clinical Research Center for Digestive Diseases
2021
Qiqihar Medical University
2020
Chinese People 's Liberation Army No.455 Hospital
2011
Expression characteristics of inflammatory factors interleukin-23 and interleukin-35; oxidative stress markers malondialdehyde, which is a final product lipid peroxidation; superoxide dismutase; microRNA-126 microRNA-146a in serum patients with coronary heart disease were investigated. Correlation between these biomarkers CACS (calcification score), as well the underlying clinical significance evaluated. A total 192 diagnosed recruited observation group, 69 healthy adults who provided their...
Type 1 diabetes (T1D) has long been considered a progressive autoimmune disease resulting in the failure of pancreatic β-cell function and absolute endogenous insulin deficiency. However, several studies have demonstrated patients with T1D detectable C-peptide levels after diagnosis, which remarkable clinical significance. Since this issue not systematically explored non-Caucasian populations, we aimed to identify prevalence residual its related features Chinese long-term patients.We...
Epitope-specific GAD65Abs and HLA-DR-DQ gene assays help improve the value of risk stratification in autoimmune diabetes mellitus protect islet function. Identification early intervention are important for latent youth (LADY). The aims this study were to investigate 1) frequencies epitope-specific genes LADY 2) association between GAD65Abs. Higher GAD65-CAb multiepitope observed young type 1 diabetes, LADY, old subjects than those adult (LADA) patients. specific susceptible HLA haplotype DR3...
This study investigated the natural progression of β-cell function in Chinese autoimmune type 1 diabetic (T1D) patients and clarified factors possibly influencing course disease.The 325 newly diagnosed T1D was assessed by fasting postprandial C-peptide (FCP PCP, respectively) levels. β-Cell failure defined as FCP <50 pM PCP <100 pM, whereas preserved >200 or >400 pM. that did not meet these criteria described residual.At initial recruitment, 33.3% had failure, 41.0% 25.8% residual function,...
Background: The detection of islet autoantibodies is essential for the accurate classification and diagnosis diabetes mellitus (DM). autoantibody distribution varies by age. However, screening strategies DM patients with different onset ages remain lacking. Materials Methods: This cross-sectional study included 17,536 from 46 medical centers across China. seroprevalence glutamic acid decarboxylase (GADA), insulinoma-associated-2 (IA-2A), zinc transporter 8 (ZnT8A), insulin (IAA) was...
To investigate the prevalence and clinical features of latent autoimmune diabetes in youth (LADY) diagnosed between 15 29 years old as a component an age-related spectrum.This nationwide, multicenter, cross-sectional study continuously included 19,100 newly patients over across China. LADY were screened from 1803 subjects aged old, with type 2 (T2D) phenotype positive autoantibodies against glutamic acid decarboxylase (GADA), insulinoma-associated-2 (IA-2A) or zinc transporter-8 (ZnT8A). The...
This study investigated insulinoma-associated-2 autoantibody (IA-2A) and zinc transporter 8 (ZnT8A) distribution in patients with type 1 diabetes (T1D) latent autoimmune (LAD) the autoantibodies' association clinical characteristics HLA-DR-DQ genes.This cross-sectional recruited 17,536 from 46 hospitals across China. A total of 189 T1D 58 LAD IA-2A positivity, 126 86 ZnT8A 231 2 (T2D) were selected to evaluate islet autoantibodies, phenotypes, gene frequency.IA-2A was bimodally distributed...