A5041538194- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Hip and Femur Fractures
- Histone Deacetylase Inhibitors Research
- Genetics and Neurodevelopmental Disorders
- Signaling Pathways in Disease
- Lower Extremity Biomechanics and Pathologies
- Cardiac, Anesthesia and Surgical Outcomes
- Hair Growth and Disorders
- Dietary Effects on Health
- Advanced Drug Delivery Systems
- DNA Repair Mechanisms
- Nanoparticle-Based Drug Delivery
- Neuroscience, Education and Cognitive Function
- Identity, Memory, and Therapy
- Dental Radiography and Imaging
- Bacterial Identification and Susceptibility Testing
- Medical Education and Admissions
- Transplantation: Methods and Outcomes
- Tryptophan and brain disorders
- Epigenetics and DNA Methylation
- Diversity and Career in Medicine
- RNA regulation and disease
- Scoliosis diagnosis and treatment
Duke University Hospital
2020-2025
Duke Medical Center
2024
Duke University
2019-2024
Athinoula A. Martinos Center for Biomedical Imaging
2018-2020
Massachusetts General Hospital
2018-2020
Yale University
2014-2019
Harvard University
2010-2019
Wuhan University
2018
Hypertension Institute
2017
Northwestern University
2017
Urinary concentrating ability is central to mammalian water balance and depends on a medullary osmotic gradient generated by countercurrent multiplication mechanism. Medullary hyperosmolarity protected from washout exchange efficient removal of interstitial fluid resorbed the loop Henle collecting ducts. In most tissues, lymphatic vessels drain excess back venous circulation. However, renal medulla devoid classic lymphatics. Studies have suggested that fenestrated ascending vasa recta (AVRs)...
Patients with schizophrenia (SCZ) experience chronic cognitive deficits. Histone deacetylases (HDACs) are enzymes that regulate circuitry; however, the role of HDACs in disorders, including SCZ, remains unknown humans. We previously determined HDAC2 mRNA levels were lower dorsolateral prefrontal cortex (DLPFC) tissue from donors SCZ compared controls. Here we investigated relationship between vivo HDAC expression and impairment patients matched healthy controls using [11C]Martinostat...
Abstract Mechanisms of neuroimmune and mitochondrial dysfunction have been repeatedly implicated in autism spectrum disorder (ASD). To examine these mechanisms ASD individuals, we measured the vivo expression 18 kDa translocator protein (TSPO), an activated glial marker expressed on membranes. Participants underwent scanning a simultaneous magnetic resonance–positron emission tomography (MR–PET) scanner with second-generation TSPO radiotracer [ 11 C]PBR28. By comparing 15 young adult males...
Abstract Age- and sex-related alterations in gene transcription have been demonstrated, however the underlying mechanisms are unresolved. Neuroepigenetic pathways regulate brain. Here, we measure vivo expression of epigenetic enzymes, histone deacetylases (HDACs), across healthy human aging between sexes using [ 11 C]Martinostat positron emission tomography (PET) neuroimaging ( n = 41). Relative HDAC increases with age cerebral white matter, correlates age-associated disruptions matter...
In most tissues, the prevailing view is that stem cell (SC) niches are generated by signals from within nearby tissue environment. Here, we define genetic changes altered in hair follicle (HF) SCs mice treated with a potent SC activator, cyclosporine A (CSA), which inhibits phosphatase calcineurin (CN) and activity of transcription factor nuclear activated T cells c1 (Nfatc1). We show CN/Nfatc1 regulates expression prolactin receptor ( Prlr ) canonical activation its downstream signaling via...
Aims Modular dual mobility (MDM) acetabular components are often used with the aim of reducing risk dislocation in revision total hip arthroplasty (THA). There is, however, little information literature about its use this context. The study, therefore, was to evaluate outcomes a cohort patients whom MDM were at THA, mean follow-up more than five years. Methods Using database single academic centre, 126 THAs 117 using design an component retrospectively reviewed. A 94 88 5.5 years included...
Robotic-assisted total joint arthroplasty (rTJA) has growing interest among patients and surgeons. However, patient in perceptions of rTJA have not been well explored. We sought to investigate the influence demographics on regarding rTJA.
Aims Tibial cones are often utilized in revision total knee arthroplasty (TKA) with metaphyseal defects. Because there few studies evaluating mid-term outcomes a sufficient cohort, the purpose of this study was to evaluate tibial cone survival and complications TKAs at minimum follow-up five years. Methods A retrospective review completed from September 2006 March 2015, 67 (64 patients) that received one specific porous during TKA. The final cohort composed 62 knees (59 years clinical or...
Abstract Staphylococcus sciuri is an occasional cause of human infection that has been described in the flora numerous animal species and environmental specimens. Here, we report a rare case S. peritonitis dialysis patient who had exposure to peridomestic animals.
Historically, orthopaedic surgery has had low female representation, with <6% of practicing surgeons identifying as female. Although prior literature illustrated gender disparities in first and last authorship well changes representation over time, less attention been paid to middle authorship. We hypothesized that trends would reflect increasing participation subspecialties coinciding an overall increase
Immunosuppressive therapies using calcineurin inhibitors, such as cyclosporine A, are associated with a higher incidence of squamous cell carcinoma formation in mice and humans. Calcineurin is believed to suppress tumorigenesis part through Nfatc1, transcription factor expressed primarily hair follicle bulge stem cells mice. However, overexpressing constitutively active Nfatc1 isoform the skin epithelium developed increased spontaneous carcinomas. Because follicular can contribute...
Purpose: Bilateral total knee arthroplasty (TKA) can be performed in patients with bilateral arthritis. Outside of nationwide database studies, which have limitations, few studies compared outcomes for same-day versus staged TKA. We sought to compare patient at a single tertiary referral center. Methods: The institutional was queried from March 2014 December 2017 primary Patients undergoing procedures were stratified by staged; length stay (LOS), disposition, 90-day emergency department (ED)...