A5101995245- Anesthesia and Pain Management
- Anesthesia and Sedative Agents
- Musculoskeletal pain and rehabilitation
- Spine and Intervertebral Disc Pathology
- Nausea and vomiting management
- Pain Mechanisms and Treatments
- Anesthesia and Neurotoxicity Research
- Spinal Hematomas and Complications
- Ion channel regulation and function
- Airway Management and Intubation Techniques
- Plant Virus Research Studies
- Opioid Use Disorder Treatment
- Healthcare and Venom Research
- Cervical and Thoracic Myelopathy
- Insect-Plant Interactions and Control
- Infectious Diseases and Tuberculosis
- Sympathectomy and Hyperhidrosis Treatments
- Pain Management and Treatment
- Pain Management and Opioid Use
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Mycobacterium research and diagnosis
- Agricultural pest management studies
- Transition Metal Oxide Nanomaterials
- Medicinal Plants and Neuroprotection
Kangdong Sacred Heart Hospital
2014-2025
Hallym University
2012-2024
Daewoong Pharmaceutical (South Korea)
2021
Kangwon National University
2008-2021
Hallym University Medical Center
2009-2021
Samsung (South Korea)
2021
Rural Development Administration
2015-2018
Seoul National University
2015-2016
National Academy of Agricultural Science
2015
New Generation University College
2015
This study investigated the chemical characteristics and microbial population during incubation of four kinds aerated compost teas based on oriental medicinal herbs compost, vermicompost, rice straw mixtures three composts (MOVR). It aimed to determine effects tea (ACT) MOVR growth promotion red leaf lettuce, soybean sweet corn. Findings showed that pH level EC slightly increased time except for tea. All contained more NO−3-N than NH+4-N. Plate counts bacteria fungi were significantly higher...
We recently showed that streptozotocin (STZ) injections in rats lead to the development of painful peripheral diabetic neuropathy (PDN) accompanied by enhancement CaV3.2 T-type calcium currents (T-currents) and hyperexcitability dorsal root ganglion (DRG) neurons. Here we used classical peripherally acting T-channel blocker mibefradil examine role T-channels as pharmacological targets for treatment PDN. When administered intraperitoneally (i.p.), at clinically relevant doses, effectively...
Abstract The Ca V 3.2 isoform of T-type voltage-gated calcium channels plays a crucial role in regulating the excitability nociceptive neurons; endogenous molecules that modulate its activity, however, remain poorly understood. Here, we used serum proteomics and patch-clamp physiology to discover novel peptide albumin (1-26) facilitates channel gating by chelating trace metals tonically inhibit via H191 residue. Importantly, also potently modulated T-currents human rodent dorsal root...
Melatonin has been reported to protect neurons from a variety of neurotoxicity. However, the underlying mechanism by which melatonin exerts its neuroprotective property not yet clearly understood. We previously demonstrated that protected kainic acid-induced neuronal cell death in mouse hippocampus, accompanied sustained activation Akt, critical mediator survival. To further elucidate action melatonin, we examined present study causal how Akt signaling pathway is regulated rat primary...
Summary Zinc is an essential trace element that plays pivotal roles in multiple facets of the immune system. Besides its catalytic and structural roles, zinc also functions as intracellular signalling molecule, changes levels can cause both direct indirect modulation responses. Further, cytoplasmic bioavailable cells are largely influenced by many extracellular stimuli. Here we provide evidence represses memory T helper type 17 responses humans inhibiting interleukin‐1 β ( IL ‐1 )‐mediated...
Complex regional pain syndrome (CRPS) is an intractable disease with various symptoms. Here, we investigated the status, work life, sleep problems, medical insurance, economic psychological and quality of life (QOL) CRPS patients.CRPS patients from 37 university hospitals in South Korea were surveyed. The survey questionnaire consisted 24 questions on following aspects patients: sex, age, occupation, cause injury, activities daily living (ADL), severity, disturbance, level education,...
The anesthetic management of patients undergoing endovascular treatment cerebral aneurysms in the interventional neuroradiology suite can be challenged by hypothermia because low ambient temperature for operating and maintaining its equipments. We evaluated efficacy skin surface warming prior to induction anesthesia prevent decrease core reduce incidence hypothermia. Seventy-two were randomized pre-warmed control group. group warmed 30 minutes before with a forced-air blanket set at 38°C....
Abstract Background We evaluated the endotracheal tube cuff pressure (P ) changes during pneumoperitoneum for laparoscopic cholecystectomy and correlations between body mass index (BMI), time, P changes. Methods Total 60 patients undergoing were allocated to either a study group (BMI ≥ 25 kg/m 2 or control < ). The intubation was performed with high-volume low-pressure cuffed oral tube. A manometer connected pilot balloon using 3-way stopcock inflated. change in defined as difference just...
Spinal myoclonus is an unusual, self-limiting, adverse event that may occur during spinal anesthesia. The exact cause and underlying biochemical mechanism of remain unclear. A few cases have been reported after administration intrathecal bupivacaine. We report a case in which recurred two episodes anesthesia with bupivacaine at 1-year interval 35-year-old woman. was acute transient. patient recovered completely, no neurologic sequelae.
Urushinol, a plant allergen, has significantly restricted the medical application of Rhus verniciflua, although it been reported to possess wide variety biological activities such as anti-inflammatory, antioxidant, and anti-cancer actions. To reduce urushinol content while maintaining beneficial activities, mushroom-mediated fermentation verniciflua was carried out this method resulted in attenuated allergenicity [1]. In present study, examine neuroprotective properties mushroom-fermented...
In Brief Study Design. Case report. Objective. To report our results of a sacroplasty technique, using 3-dimensional C-arm CT for the treatment sacral body fracture. Summary Background Data. Sacroplasty may provide symptomatic relief and hasten recovery in insufficiency fractures. knowledge, there is no case literature describing application We present patient who had percutaneous fracture alar under guidance discuss clinical technical considerations. Methods. The procedure included standard...
Spontaneous retropharyngeal hematoma is rare and difficult to diagnosis early. A 23-year-old male spontaneously developed acute onset of neck pain, limitation motion, mild dysphagia. Magnetic resonance imaging demonstrated blood products in prevertebral space from C2 C4, suggesting a hematoma. We report case spontaneous causing pain.
A 51-year-old man with a 1-month history of lower back pain and radiating visited to our clinic. magnetic resonance imaging (MRI) scan demonstrated cyst like mass at the level L4-5 interspace compression thecal sac nerve root on right side. We performed percutaneous needle aspiration lumbar zygapophyseal joint synovial under fluoroscopic guidance. The patient felt an immediate relief symptoms after aspiration, had no signs or recurrence follow-up 6 months later. No demonstrable lesion was...
Use of opioids for chronic intractable pain is increasing globally, and their proper use can improve patients' quality life. In contrast, opioid disorders, such as abuse or addiction, caused by prescribing opioids, are a worldwide issue. This study aimed to understand current patterns physicians' experiences with in South Korea.Pain physicians 42 university hospitals Korea were asked complete anonymous questionnaires regarding prescriptions.A total 69 surveys completed. Most started at score...
Chronic pain affects approximately 22% of the world's population. Opioids can be useful in chronic management. However, some patients have negative perception opioids. The purpose this research was to evaluate patients' about opioids and investigate problems associated with prescribing taking South Korea.Patients who visited a clinic 14 university hospitals Korea from September through October 2018 were asked complete anonymous questionnaires opioids.Of 368 that surveyed (female 53.3%, male...
A 68-year-old woman suffered from lower back and radiating pain on her right buttock posterior calf. Axial magnetic resonance imaging showed a 7 × mm nodular lesion (T1 and, T2 low signal intensity) at the epidural space between L5-S1 level computed tomography revealed it was an gas cyst. The authors performed block percutaneous needle aspiration of patient almost complete resolution symptoms one year later. suggest that nerve with cyst could be alternative treatment option for patients...
Morphine is widely used in pain management although the risk of side effects significant. The use biased agonists to G protein μ-opioid receptors has been suggested as a potential solution, oliceridine and PZM21 have previously failed demonstrate benefits clinical studies. An amplification-induced confusion process comparing beta-arrestin pathways may account for agonist misidentification. Here, we devised strategy discover with intrinsic efficacy. We computationally simulated 430 000...
Background We evaluated the effect and safety of immediate postoperative continuous infusion remifentanil at two doses in patients undergoing laparoscopic-assisted vaginal hysterectomy (LAVH) with alfentanil-based patient-controlled analgesia (PCA). Methods The study enrolled 50 ASA physical status 1 or 2 scheduled to undergo LAVH. Anesthesia was maintained sevoflurane-remifentanil-air. At last skin suture, sevoflurane discontinued, were randomized receive 0.05 µg/kg/min (group I) 0.1 II)....
환자 관리에 있어서 중심정맥 도관 삽관은 기본적 술기 이며 심혈관계 감시, 대량 수혈, 수액투여 및 승압제 투약 등에 유용하게 사용된다.또한 장기 항생제, 항암제, 비경구 영양 요법 등에도 유용하며 때로 필수적인 수기이다. 1) 중심 정맥도관을 주로 시행하는 부위는 내경정맥, 쇄골하정맥, 대퇴정맥 등이며 삽관 시 여러 가지 기계적 손상, 감염, 혈전성 합병증들이 발생할 수 있고 선택된 부위에 따 라 그 빈도가 조금씩 다르게 나타난다.쇄골하정맥 천자 합병증은 6.2-10.7%의빈도로 발생한다고 알려져 그중 혈흉은 0.4-0.6%의빈도로 발생하는 것으로 알 려져 있으며 2) 환자의 자세를 적절하게 취함으로써 그러한 합병증의 빈도를 줄일 있다.어떠한 원인 에서든 객혈이 발생하면 기관내 흡인 등을 통해 혈액과 각 종 분비물 제거하여 기도의 통기성과 청결을 유지하 는 것이 최우선이며 3) 후 기관지경 이용하여 출혈 부위를 확인하고 적절한