A5101809998- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Monoclonal and Polyclonal Antibodies Research
- Cancer Immunotherapy and Biomarkers
- nanoparticles nucleation surface interactions
- Developmental Biology and Gene Regulation
- Cancer Cells and Metastasis
- Magnesium Oxide Properties and Applications
- Multiferroics and related materials
- Kruppel-like factors research
- Chalcogenide Semiconductor Thin Films
- Anesthesia and Sedative Agents
- RNA Research and Splicing
- Hedgehog Signaling Pathway Studies
- Quantum Dots Synthesis And Properties
- Anesthesia and Pain Management
- Immune Cell Function and Interaction
- Surface and Thin Film Phenomena
- Theoretical and Computational Physics
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer Research and Treatments
- Ultrasound and Cavitation Phenomena
- Colorectal Cancer Treatments and Studies
- Acoustic Wave Resonator Technologies
- Nanowire Synthesis and Applications
Fudan University Shanghai Cancer Center
2021-2024
Shanghai Clinical Research Center
2024
Shanghai Medical College of Fudan University
2024
Nanjing Drum Tower Hospital
2017-2023
Nanjing University
2003-2021
Cancer Institute (WIA)
2021
Zaozhuang Municipal Hospital
2015-2020
BACKGROUND. Recent genomic and bioinformatic technological advances have made it possible to dissect the immune response personalized neoantigens encoded by tumor-specific mutations. However, timely efficient identification of is still a major obstacle neoantigen-based cancer immunotherapy.
Abstract Poor infiltration of activated lymphocytes into tumors represents a fundamental factor limiting the therapeutic effect adoptive cell immunotherapy. A tumor-penetrating peptide, iRGD, has been widely used to deliver drugs tumor tissues. In this study, we demonstrate for first time that iRGD could also facilitate in both 3D spheroids and several xenograft mouse models. addition, combining modification with PD-1 knockout reveals superior anti-tumor efficiency. Mechanistic studies...
Background Poor infiltration and limited activation of transferred T cells are fundamental factors impeding the development adoptive cell immunotherapy in solid tumors. A tumor-penetrating peptide iRGD has been widely used to deliver drugs deep into tumor tissues. CD3-targeting bispecific antibodies represent a promising which recruits activates cells. Methods T-cell penetration was demonstrated spheroids using confocal microscope, xenografted tumors by histology vivo real-time fluorescence...
3046 Background: Recent genomic and bioinformatic technological advances have made it possible to dissect the immune response personalized neoantigens encoded by tumor-specific mutations.However, rapid efficient identification of is still fraught with difficulty, a systematic evaluation based immunotherapy in advanced refractory epithelial tumors lacking. Methods: Tumor ctDNA samples from 16 cancer patients were underwent mutational profiling cancer-associated genes panel. Neoantigens...
Cervical cancer is the third most common malignancy worldwide, accounting for 250,000 mortalities annually. Notch1, an important regulator of cell‑fate decisions and differentiation, has been found to be overexpressed in certain types cancer. However, role Notch1 cervical carcinogenesis remains unclear. In present study, immunohistochemical staining western blot analysis revealed that expression was significantly higher tissues than normal tissues. Furthermore, statistical associated with...
Poor penetration of transferred T cells represents a critical factor impeding the development adoptive cell therapy in solid tumors. We demonstrated that iRGD-antiCD3 modification promoted both infiltration and activation our previous work. Interest low-dose radiotherapy has recently been renewed due to its immuno-stimulatory effects including recruitment. This study aims explore synergistic between iRGD-antiCD3-modified cells.
Abstract T cell receptor‐engineered (TCR‐T) therapy has demonstrated therapeutic effects in basic research and clinical trials for treating solid tumors. Due to the peptide‐dependent recognition human leukocyte antigen (HLA)‐restriction, TCR‐T is generally custom designed target individual antigens. The lack of suitable universal targets tumor cells significantly limits its applications. Establishing a treatment strategy great significance. This study evaluated HLA‐peptide‐addressing (HAUL)...
It was previously reported that targeting vascular epithelial growth factor (VEGF)/VEGFR could modulate the antitumor immunity. VEGFR2 inhibitor YN968D1 is a highly selective and approved for treatment of late-stage gastric cancer in 2014, but its role immunity remains unknown.In this study, we investigated effects on function T cells vitro by testing cytotoxicity cytokine production. Next, constructed peritoneal dissemination subcutaneous mouse model to assess YN968D1-treated vivo,...
Background: T cell-redirecting bispecific antibodies (BsAbs) are emerging as a potent cancer therapy that crosslinks tumor cells and by simultaneously binding to tumor-associated antigen CD3ϵ. However, immune inhibitory molecules can be remarkably upregulated after BsAbs treatment, leading suppressive microenvironment treatment resistance. This partially reversed combination with checkpoint inhibitors. In our previous work, we successfully constructed the recombinant protein iRGD-antiCD3...
Ferroelectric domain configurations and microstructural defects in the Bi- Zn-modified Pb(Ni <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1/3</sub> Nb xmlns:xlink="http://www.w3.org/1999/xlink">2/3</sub> )O xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> -PbZrO -PbTiO piezoelectric ceramics were investigated by transmission electron microscopy (TEM) selected area diffraction. In samples with tetragonal symmetry, labyrinthic 90deg a-c...
We report on the effects of reactive conditions formation BT nanoparticles via hydrothermal process with a focus their atomic-scale surface microstructures and structural defects characterized by HRTEM. The results showed that large Ba/Ti molar ratios in precursors could lead to particles cubic morphology. Smaller weaker agglomeration behavior were observed products synthesized solvothermal using ethylene glycol (EG) as reaction medium, comparison either pure water or water-EG mixed solution...
Rutile TiO 2 nanorods have been successfully prepared by a sonochemical method. The microstructures of were investigated in detail transmission electron microscopy (TEM), selected area diffraction (SAED) and high-resolution (HREM). Probable mechanisms for the formation are proposed.