A5088092816- Phytochemicals and Antioxidant Activities
- Protein Hydrolysis and Bioactive Peptides
- Medicinal Plant Research
- Natural Antidiabetic Agents Studies
- Microbial Inactivation Methods
- Biochemical Analysis and Sensing Techniques
- Proteins in Food Systems
- Natural product bioactivities and synthesis
- Drug-Induced Hepatotoxicity and Protection
- Biochemical effects in animals
- Liver Disease Diagnosis and Treatment
- Computational Drug Discovery Methods
- Phytochemistry and Bioactive Compounds
- Tea Polyphenols and Effects
- Microbial Metabolites in Food Biotechnology
- Meat and Animal Product Quality
- Essential Oils and Antimicrobial Activity
- Phytochemical compounds biological activities
- Postharvest Quality and Shelf Life Management
- Moringa oleifera research and applications
- Physics of Superconductivity and Magnetism
- Nuts composition and effects
- Free Radicals and Antioxidants
- Food composition and properties
- Peptidase Inhibition and Analysis
Kunming University of Science and Technology
2016-2025
Yunnan Machinery Research and Design Institute
2023-2025
Chinese Academy of Sciences
2001-2024
Technical Institute of Physics and Chemistry
2024
Kunming University
2019-2024
Icahn School of Medicine at Mount Sinai
2023
State Council of the People's Republic of China
2019-2020
Caerus Molecular Diagnostics (United States)
2019
Sichuan University
2019
University of Freiburg
2019
Many peptides are contained in rice wine, which may have various bioactivities, and need to be investigated. The aim of this study was identify novel with high α-glucosidase inhibition antioxidant activities wine illustrate their underlying mechanisms. Peptide composition, the different elution fractions from macroporous resin adsorption chromatography were Potentially bioactive screened via silico analyses validated by vitro experiments, then, mechanisms further investigated molecular...
The aim of present work was to investigate the effect solid-state fermentation with filamentous fungi (Aspergillus oryzae var. effuses, Aspergillus oryzae, and niger) on total phenolics content (TPC), flavonoids, antioxidant activities four subfractions oat, namely, n-hexane, ethyl acetate (EA), n-butanol, water, compare them their corresponding unfermented oat. TPC flavonoids increased dramatically, especially in EA (p < 0.05). levels activity were also significantly enhanced highest found...
This work was designed to comparatively investigate 27 dietary flavonoids that act as α-glucosidase inhibitors and insulin sensitizers. On the basis of results an in vitro experiment inhibition, myricetin (IC50 = 11.63 ± 0.36 μM) possessed strongest inhibitory effect, followed by apigenin-7-O-glucoside 22.80 0.24 fisetin 46.39 0.34 μM). A three-dimensional quantitative structure–activity relationship model with good predictive capability [comparative molecular field analysis, q2 0.529,...
The present work investigated the effect of 90 days' traditional fermentation on phytochemicals and inhibition towards α-glucosidase dipeptidyl peptidase-IV (DPP-IV) pickled chili pepper, clarified their possible mechanisms based molecular docking analysis. results show that significantly enhanced for but reduced inhibitory effects DPP-IV (P < 0.05), especially fermented 42 days. In peppers, a total 12 phytochemical compounds were characterized quantified, which kaempferol-3-O-rutinoside,...
The purpose of the present work is to study pancreatic lipase inhibitory effects different subfractions (n-hexane, ethyl acetate (EA), n-butanol, and water) from ethanol extracts nonfermented fungi-fermented oats delineate interactions three primary phenolic acids in EA subfractions. subfraction showed highest effect on activity at 1.5 mg/mL compared other subfractions, regardless whether were fermented. Meanwhile, both two demonstrated more effective than that oats. A positive correlation...
Flavonoids often show inconsistent antioxidant activities (AAs) depending on the assay used. The electrochemical properties of 14 flavonoid standards in cyclic voltammetry [area under anodic wave (Q) and oxidant peak potentials (Epa)] structural parameters [bond dissociation enthalpy (BDE) ionization potential (IP)] were investigated. They compared with results four spectrophotometric assays, namely, diphenyl-1-picrylhydrazyl (DPPH), Folin-Ciocalteu reagent (FCR), ferric reducing ability...
This study aimed to explore the potential of umami peptides for lowering blood glucose. Molecular docking results showed that LADW and EEAEGT bound active amino acid residues α-glucosidase via hydrogen bonds Van der Waals forces, a finding supported by an independent gradient model (IGM). dynamics (MD) simulations demonstrated can decelerate outward expansion reduce fluctuations at site. In vitro findings indicated potent inhibitory activity against α-glucosidase, with IC50 values 4.40 ±...
Hyperuricemia (HUA) is a prevalent chronic disease, characterized by excessive blood uric acid levels, that poses significant health risk. In this study, the preventive effects and potential mechanisms of ethanol extracts from Chinese sumac (Rhus chinensis Mill.) fruits on HUA nephropathy were comprehensively investigated. The results demonstrated reduction in levels hyperuricemia mice after treatment with fruit extract, especially high-dose group, where level decreased 39.56%. Visual...