A5020551232- Cancer, Lipids, and Metabolism
- Computational Drug Discovery Methods
- Microbial Metabolism and Applications
- Drug Transport and Resistance Mechanisms
- Galectins and Cancer Biology
- Adipokines, Inflammation, and Metabolic Diseases
- Aortic aneurysm repair treatments
- Diet and metabolism studies
- Signaling Pathways in Disease
- Ovarian cancer diagnosis and treatment
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal motility and disorders
- Ovarian function and disorders
- Medicinal Plants and Bioactive Compounds
- Peripheral Artery Disease Management
- NF-κB Signaling Pathways
- Cholesterol and Lipid Metabolism
- Abdominal Surgery and Complications
- Cardiac Fibrosis and Remodeling
- Drug Solubulity and Delivery Systems
- Atherosclerosis and Cardiovascular Diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cynara cardunculus studies
- Exercise and Physiological Responses
- Surfactants and Colloidal Systems
Xinjiang Medical University
2024
State Administration of Traditional Chinese Medicine of the People's Republic of China
2022
Peking University
2017-2022
Shihezi University
2017-2021
National Health and Family Planning Commission
2021
Ministry of Education of the People's Republic of China
2019-2020
Purpose: Heart failure (HF) is a leading cause of morbidity and mortality worldwide, it characterized by cardiac hypertrophy fibrosis. However, effective treatments are not available to block fibrosis after hypertrophy. The QiShenYiQi pill (QSYQ) an treatment for chronic HF. the underlying mechanism remains unclear. Methods: In present study, pressure overload-induced model was established in rats inducing ascending aortic stenosis 4 weeks. QSYQ administered 6 weeks, its effects on fibrosis,...
Tilianin, a representative flavonoid ingredient of Dracocephalum moldavica L., has been used to treat several diseases for centuries, including atherosclerosis (AS). However, pharmacological mechanisms underlying its biological functions remain elusive. In the present study, we investigated anti-AS tilianin through establishing in vitro models using three types cells that contributed AS progression, macrophage, vascular smooth muscle and human umbilical vein endothelial cells, which were...
To investigate the effects of Bushen Huatan Granules (BHG) and Kunling Wan (KW), two Chinese medicines, on regulation polycystic ovary syndrome (PCOS) their underlying mechanisms.PCOS rat model was established by subcutaneous injection dehydroepiandrosterone (DHEA) (6 mg/100 g/day) for 20 days, followed treatment with BHG (0.75, 1.49, 2.99 g/kg) or KW (0.46, 0.91, 1.82 gavage 4 weeks. Estrous cycle detected vaginal smears. Follicles development assessed histology. Levels testosterone insulin...
Background and Purpose Abdominal aortic aneurysm (AAA) is a degenerative disease with irreversible progressive dilation of the artery. But there are few options for efficacious treatment except traditional surgery. Probucol has been widely applied to treat hyperlipidaemia atherosclerosis in clinic, but whether it can protect against AAA remains unknown. In this study, protective effects probucol its related mechanisms were explored. Experimental Approach The model was induced mice by...
Background: Yu-ping-feng powder (YPF) is a compound traditional Chinese medicine extensively used in China for respiratory diseases. However, the role of YPF alveolar-capillary barrier dysfunction remains unknown. This study aimed to explore effect and potential mechanism on injury induced by exhausted exercise. Methods: Male Sprague–Dawley rats were establish an exhausted-exercise model using motorized rodent treadmill. at doses 2.18 g/kg was administrated gavage before exercise training 10...
Nanoliposome is a useful dosage form to increase solubility and absorption of simvastatin (SMV), consequently improves its therapeutic effects. However, in vivo toxicity SMV could also be elevated accompanied by the enhancement, which decisive factor for clinical application nanoliposome (SMV-Lipo), but has not been studied systematically reported so far. In this study, organ SMV-Lipo was evaluated mice presence absence isoproterenol compared those free SMV. Results demonstrated that SMV,...
Pathophysiological vascular remodeling in response to disturbed flow with low and oscillatory shear stress (OSS) plays important roles atherosclerosis progression. Pomegranate extraction (PE) was reported having anti-atherogenic effects. However, whether it can exert a beneficial effect against flow-induced pathophysiological inhibit remains unclear. The present study aims at investigating the effects of pomegranate peel polyphenols (PPP) its purified compound punicalagin (PU), as well their...
Background: Chronic stress-induced diarrhea is a common clinical condition, characterized by an abnormal bowel movement and loose stools, which lacks effective treatment in the clinic. Si-Ni-San (SNS) compound traditional Chinese medicine extensively used China for stress-related diarrhea. However, mechanism unclear. Methods: Male Wistar rats (200 ± 20 g) were placed restraint cylinder fixed horizontally 3 h once daily 21 consecutive days to establish chronic stress (CRS) rat model. SNS...