A5027273930- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Liver Disease Diagnosis and Treatment
- Burkholderia infections and melioidosis
- Genetics, Bioinformatics, and Biomedical Research
- Hepatitis B Virus Studies
- Epigenetics and DNA Methylation
- Machine Learning in Bioinformatics
- Hepatitis C virus research
- Animal Genetics and Reproduction
- Heat Transfer and Optimization
- Radiomics and Machine Learning in Medical Imaging
- Hearing, Cochlea, Tinnitus, Genetics
- Advancements in Transdermal Drug Delivery
- Consumer Attitudes and Food Labeling
- Multidisciplinary Warburg-centric Studies
- High-pressure geophysics and materials
- Big Data Technologies and Applications
- Heavy Metal Exposure and Toxicity
- Cancer-related gene regulation
- Plant Pathogenic Bacteria Studies
- Advanced Data Compression Techniques
- Advanced Image Processing Techniques
- Parasites and Host Interactions
- Genetics and Neurodevelopmental Disorders
Indian Council of Medical Research
2023-2024
Sri Sivasubramaniya Nadar College of Engineering
2023
Bar-Ilan University
2017-2021
Radboud University Nijmegen
2010-2011
Radboud University Medical Center
2011
Extracellular vesicles (EV) secreted by pathogens function in a variety of biological processes. Here, we demonstrate that the protozoan parasite Trypanosoma brucei, exosome secretion is induced stress affects trans-splicing. Following perturbations biogenesis spliced leader RNA, which donates its (SL) exon to all mRNAs, or after heat-shock, SL RNA exported cytoplasm and forms distinct granules, are then exosomes. The exosomes formed multivesicular bodies (MVB) utilizing endosomal sorting...
In this study, we report that the ability of human pathogen Leishmania to sense and monitor lack arginine in phagolysosome host macrophage is essential for disease development. Phagolysosomes macrophages are niche where resides causes leishmaniasis. During infection, concentration decreases as part innate immune response. An sensor on cell surface activates an deprivation response pathway upregulates expression a parasite transporter (AAP3). Here, use CRISPR/Cas9-mediated disruption AAP3...
Nanoparticles (NPs) based drugs for topical administration are gaining interest in the biomedical world. However, a study tool of their penetration depth to different tissue layers without additional markers or contrast agents is required order relieve safety concerns. While common diagnostic tools, e.g. X-ray, computed tomography magnetic resonance imaging, can provide vivo detection metallic NPs, resolution cannot determine exact thin skin layers. In this work, we propose noninvasive...
Leishmaniasis is among the five parasitic diseases that still require development of new drugs. Ultrasmall cerium (Ce3/4+) cation-doped maghemite (γ-Fe2O3) nanoparticles (NPs) were tested as a potential drug to treat visceral leishmaniasis, disease affecting millions people worldwide. The NPs engineered for binding polycationic branched polyethylenimine (PEI) polymer, thereby rupturing single lysosome these parasites and enabling entry anti-Leishmania drug, pentamidine. Exploiting known...
Background: India is rich in tribal population including north-east India. This research of ours based on viral hepatitis diagnosis (HBV, HCV, HDV. HAV. HEV) and prevalence the eight north eastern states (namely Assam, Arunachal, Nagaland, Sikkim, Tripura, Meghalaya, Manipur, Mizoram) that are locations bordering other countries like Bangladesh, Bhutan Nepal. The article intercompares pattern non-tribal patients as well overall pre-COVID-19 during COVID-19. Methodology: cross-sectional study...
Background: Viral hepatitis is of global importance and inflicts a huge healthcare cost in northeast India where its prevalence the drug-resistant variants are not well known. Hepatotropic viruses (hepatitis B virus, A C virus E virus) known to cause ‘viral hepatitis.’ This study documents genotype Hepatitis Virus (HCV) India.Aim: Identification genotypes with their resistance-associated (RAVs) could facilitate development selective antiviral drug regimens against HCV infection. The present...
Background: Burkholderia pseudomallei is a Gram –negative bacteria that can cause the fatal disease of Melioidosis with mortality ranging from 21-40% in different countries. Further, highly resilient environmental pathogen and live as free-living bacterium soil, water parasite within amoeba, fungi, animal cells. It known to have developed adaptation stressful factors like salinity, iron levels, oxidation. Widely this associated agricultural activities, construction activities hence farmers,...
Abstract Arginine homeostasis in lysosomes is critical for growth and metabolism of mammalian cells. They employ a specific sensor (SLC38A9) that monitors intra-lysosome arginine sufficiency subsequently up-regulates cellular mTORC1 activity. Lysosomes macrophages (phagolysosomes) are the niche where parasitic protozoan Leishmania resides causes important human disease. Several years ago, we discovered upon starvation, cultured parasites promptly activate MAPK2-mediated Deprivation Response...
Infertility issues can be attended to by in vitro maturation (IVM) of an imma- ture oocyte into a developmentally compe- tent followed fertilisation (IVF). The hypothesis presented here is consolidated logical outcome indepen- dent research publications concluding suggesting photoirradiation granulosa cu- mulus cells and oocytes as means influ - ence IVM IVF humans animals with possible outcomes discussed. INTRODUCTION Fertility are mostly associated the quality 1 which turn determined its...
<sec> <title>UNSTRUCTURED</title> ALBI (Albumin-Bilirubin) score is routinely used in grading liver function of hepatocarcinoma and hepatitis patients. In this purposive review, the published values serum albumin, bilirubin Viral hepatitis, Tuberculosis, Scrub Typhus, Enteric fever has been compared with that melioidosis. Since PubMed yielded zero searches key words “albumin, bilirubin, melioidosis”, it was searched Google Scholar, a better retrievable search engine. This 46 relevant...
ALBI (Albumin-Bilirubin) score is routinely used in grading liver function of hepatocarcinoma and hepatitis patients. In this purposive review, the published values serum albumin, bilirubin Viral hepatitis, Tuberculosis, Scrub typhus, Enteric fever has been compared with that melioidosis. Since PubMed yielded zero searches key words “albumin, bilirubin, melioidosis”, it was searched Google Scholar, a better retrievable search engine. This 46 relevant articles 53 scores for Melioidosis. An...
Image compression is crucial task in the current era. This mainly due to ubiquitous nature of images applications we use today and with need transmit these without spending fortunes while also maintaining quality up a certain mark. paper will provide an insight into problems image compression, comparing different models. In this paper, autoencoders, SVDs, GANs, JPEG, K-means, PCA models are used perform compression. It further aims compare performance aforementioned understand which model...
The causative agent of melioidosis Burkholderia pseudomallei is a Gram-negative soil bacterium that can cause fatal infection in people with occupational hazards related to environmental exposure. Since be misdiagnosed withother diseases like scrub typhus, this motivatedto use non-serological technique dermal lesion pattern-based differentiation and typhus. In article, ImageJ plugin-3D surface plot was used analyze the pattern. Pub Med search using key words “Skin Lesion Melioidosis” Scrub...
Abstract There is significance in the molecular weight derived sequence patterns of adenosine, guanosine, cytosine, thymine, methyl cytosine and hydroxyl if one has to consider events holistically by including single nucleotide polymorphisms, tumor suppressor gene activity like that ten eleven translocation gene, CpG methylation, miRNA SNP SNPs neighboring CpGs. This research article focuses on observing simulation results validated a using substitution A, G, C, T, 5OHC, 5MC. The outcome...
DNA methylation maintains allele specific gene expression (Chan et al., 2003) in which miRNA influences allele-specific protein and SNPs, found inside miRNA, turn tumor susceptibility (Nicoloso 2010). Further, methylated CpGs have been correlated to APC colorectal cancer (Zhang 2007) retrotranspositions also (Miki 1992). Another aspect unrelated it is Tet1 gene, has associated with the conversion of methylcytosine hydroxymethyl cytosine (Tahiliani 2009). DNA might a role prevention normal...
There is significance in the molecular weight derived sequence patterns of adenosine, guanosine, cytosine, thymine, methyl cytosine and hydroxyl if one has to consider events holistically by including single nucleotide polymorphisms, tumor suppressor gene activity like that ten eleven translocation gene, CpG methylation, miRNA SNP SNPs neighboring CpGs. This research article focuses on observing simulation results validated a using substitution A, G, C, T, 5OHC, 5MC. The outcome helped bring...