A5062912789- Ruminant Nutrition and Digestive Physiology
- SARS-CoV-2 and COVID-19 Research
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- vaccines and immunoinformatics approaches
- COVID-19 Clinical Research Studies
- Algal biology and biofuel production
- Genetic and phenotypic traits in livestock
- Immune Cell Function and Interaction
- Aquaculture Nutrition and Growth
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Dermatology and Skin Diseases
- Animal Nutrition and Physiology
- Fermentation and Sensory Analysis
- Healthcare professionals’ stress and burnout
- Horticultural and Viticultural Research
- Empathy and Medical Education
- Phytase and its Applications
- Ocular Surface and Contact Lens
- Health, psychology, and well-being
- Mineral Processing and Grinding
- Cyclone Separators and Fluid Dynamics
- Mindfulness and Compassion Interventions
- Alcohol Consumption and Health Effects
University of Hohenheim
2016-2025
University Medical Center Freiburg
2019-2023
University of Freiburg
2019-2023
University of Tübingen
2021
Technische Hochschule Ulm
2018
Friedrich-Alexander-Universität Erlangen-Nürnberg
2014-2017
SARS-CoV-2 spike mRNA vaccines
Abstract Continuously emerging variants of concern (VOCs) sustain the SARS-CoV-2 pandemic. The Omicron/B.1.1.529 VOC harbours multiple mutations in spike protein associated with high infectivity and efficient evasion from humoral immunity induced by previous infection or vaccination. By performing in-depth comparisons SARS-CoV-2-specific T-cell epitope repertoire after messenger RNA vaccination, we demonstrate that spike-derived epitopes were not dominantly targeted convalescent individuals...
The chemical composition of 16 microalgae products four genera, Arthrospira (n = 2), Chlorella 8), Nannochloropsis 4) and Phaeodactylum was assayed to evaluate the intra- inter-genera variation nutrient profiles commercial products. Crude protein main component in all followed by ether extract crude ash. Mean concentrations were 690, 502, 431 446 g/kg dry matter, mean 63, 157, 188 113 matter for Arthrospira, Chlorella, respectively. However, there considerable inter- intra-genera variation....
Burnout and stress-related mental disorders (depression, anxiety) occur in medical students physicians with a significantly higher prevalence than the general population. At same time, learning of coping mechanisms against stress is still not an integral part education. In this pilot study we developed elective course for relaxation techniques examined condition before after course. 42 participated semester courses 2012 2013 as well survey at start end each The were instructed autogenic...
Effectiveness of seasonal influenza vaccination varies between individuals and might be affected by history among other factors. Here we show, monitoring frequencies CD4 T cells specific to the conserved hemagglutinin epitope HA
The neuronal Na+-activated K+ channel Slack (aka Slo2.2, KNa1.1, or Kcnt1) has been implicated in setting and maintaining the resting membrane potential defining excitability firing patterns, as well generation of slow afterhyperpolarization following bursts action potentials. activity increases significantly under conditions high intracellular Na+ levels, suggesting this may exert important pathophysiological functions. To address these putative roles, we studied whether channels contribute...
<title>Abstract</title> <italic>In vitro</italic> gas production (GP) is commonly used to evaluate ruminant feed, yet its accurate interpretation requires robust mathematical modeling. This study systematically explores a wide array of nonlinear models explain GP dynamics across various feed types, addressing the question: how can efficient and versatile that accurately represent profiles be identified? We hypothesized distinct types exhibit unique characteristics, effectively captured by...
Abstract The objective of this study was to investigate ruminal fermentation and the nutritional value different microalgae products ( MAP ) for ruminants, including inter‐ intra‐genera variability. Furthermore, effect mechanical cell disruption also evaluated. Cell‐disrupted nondisrupted four genera were investigated using Hohenheim Gas Test. investigations included characterization gas production GP ), volatile fatty acids VFA methane, organic matter digestibility, energetic as well...
Here, it was investigated whether substitution of amino acids (AA) from soy protein isolate with free AA in low crude diets influences the growth performance and N utilisation broilers, interactions dietary glycine equivalent (Glyequi) concentration exist. Birds were distributed two 2 × factorial arrangements 48 floor pens containing 10 birds each, plus metabolism cages each. Experimental feed provided for ad libitum consumption d 7 to 22. Diets contained either a at 79 g/kg or mix AA, which...
The pathogenesis of chronic inflammatory bowel diseases (Crohn's disease [CD] and ulcerative colitis) involves dysregulated TH1 TH17 cell responses, which can be targeted therapeutically by the monoclonal antibody Ustekinumab directed against joint p40 subunit IL-12 IL-23. These cytokines may also regulate differentiation T follicular helper (TFH) cells, promote B function in germinal centers. However, role TFH cells CD impact therapy on fate patients are poorly defined.Lymphocytes were...
This study aimed to investigate the effects of two brown Icelandic seaweed samples ( Ascophyllum nodosum and Fucus vesiculosus ) on in vitro methane production, nutrient degradation, microbiota composition. A total mixed ration (TMR) was incubated alone as control or together with each at inclusion levels (2.5 5.0% a dry matter basis) long-term rumen simulation technique (Rusitec) experiment. The incubation period lasted 14 days, 7 days adaptation sampling. concentration gas produced...
Purpose: The S100 fused-type proteins hornerin (HRNR) and filaggrin-2 (FLG2) are members of the epidermal differentiation complex, which is involved in terminal keratinocytes via cornification as well maintenance antimicrobial barrier. We investigated expression possible regulation HRNR FLG2 at ocular surface lacrimal apparatus. Methods: Tissues apparatus were analyzed systematically by means RT-PCR, immunohistochemistry, immuntransmission electron microscopy (iTEM) for their ability to...
Abstract CD8+ T cells are critical for the elimination and long-lasting protection of many viral infections, but their role in current SARS-CoV-2 pandemic is unclear. Emerging data indicates that SARS-CoV-2-specific detectable majority individuals recovering from infection. However, optimal virus-specific epitopes, pre-existing heterologous immunity as well kinetics differentiation program during disease control have not been defined detail. Here, we show both newly induced T-cell responses...
Abstract SARS-CoV-2 spike mRNA vaccines mediate protection from severe disease as early 10 days post prime vaccination, when specific antibodies are hardly detectable and still lack neutralizing activity. Vaccine-induced T cells, especially CD8+ may thus be the main mediators of at this stage. The details antigen-specific cell induction after prime/boost their comparison to naturally induced responses association with other arms vaccine-induced adaptive immunity remain, however, incompletely...
Circulating Th1-biased follicular T helper (cTfh1) cells have been associated with antibody responses to viral infection and after vaccination but their B cell functionality is less understood. After elimination, Tfh1 are the dominant subset within circulating Hepatitis C Virus (HCV)-specific CD4 cells, functional capacity currently unknown. To address this important point, we established a clone-based system evaluate in vitro overcome experimental limitations low frequencies. Specifically,...
ABSTRACT The ruminant-microorganism symbiosis is unique by providing high-quality food from fibrous materials but also contributes to the production of one most potent greenhouse gases—methane. Mitigating methanogenesis in ruminants has been a focus interest past decades. One promising strategies combat methane use feed supplements, such as seaweeds, that might mitigate via microbiome modulation and direct chemical inhibition. We conducted vitro investigations effect three seaweeds (...
In vitro studies of gas production (GP) using rumen fluid obtained from rumen-cannulated animals are common in feed evaluation for ruminants. The objective was to compare sheep faeces with dairy cows as inocula the Hohenheim test (HGT) a large number different-quality feeds. It then evaluated whether GP by inoculum (RI-GP) can be estimated faecal (FI-GP). Ninety feeds ruminants including roughages (n = 27), total mixed rations 6), commercial compound 18), cereal grains 10), energy-rich...
The photoinactivation properties of 405 (violet) and 470 nm (blue) light have been studied by many research groups within the last few years. Both wavelengths are capable disinfecting bacteria fungi, with radiation being more efficient. basic mechanism is understood for nm. Violet absorbed endogenous porphyrins that act as photosensitizers generate reactive oxygen species, subsequently destroying microorganisms from within. underlying photobiological 470nm still unclear though flavins widely...