A5011680921- Drug Transport and Resistance Mechanisms
- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Pharmacological Effects and Toxicity Studies
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Peptidase Inhibition and Analysis
- Drug-Induced Hepatotoxicity and Protection
- Trace Elements in Health
- Amino Acid Enzymes and Metabolism
- Gastroesophageal reflux and treatments
- MicroRNA in disease regulation
- Ocular Surface and Contact Lens
- RNA Interference and Gene Delivery
- Antibiotics Pharmacokinetics and Efficacy
- Pediatric Hepatobiliary Diseases and Treatments
- Pancreatic function and diabetes
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Stress Responses and Cortisol
- Fibroblast Growth Factor Research
- Advanced Drug Delivery Systems
- Nutrition and Health in Aging
- Protein Kinase Regulation and GTPase Signaling
Japan Bio Products (Japan)
2009-2022
Shibuya (Japan)
1997-2015
Choshu Industry (Japan)
2008-2014
National University of Sciences and Technology
2010
Dalian Medical University
2010
The University of Tokyo
1998
The purpose of this study was to investigate the pharmacokinetic mechanism interaction between JBP485 (cyclo-trans-4-L-hydroxyprolyl-L-serine, a dipeptide) and cephalexin when they were coadministered in rats. plasma concentrations both decreased significantly after oral combination, but little difference observed simultaneous intravenous administration two agents, suggesting that target localized intestine during absorption process. uptake everted intestinal sacs jejunal perfusions...
The effect of human placental extract (HPE) on liver regeneration in rats was investigated. After intravenous administration HPE to a-naphthylisothiocyanate (ANIT)-intoxicated rats, the labeling index hepatocytes significantly increased a level 16.5 times higher than that control. A 1/500 dilution directly stimulated DNA synthesis primary culture. heated at 121 degrees C did not stimulate vivo or hepatocyte culture, suggesting contains heat-unstable but potent mitogens for hepatocytes....
It has been a desire to develop orally effective therapeutic agents that restore the liver function in chronic injury. Here we demonstrated trans-4-L-hydroxyprolyl-L-serine (JBP923) and cyclo-trans-4-L-hydroxyprolyl-L-serine (JBP485), which was previously isolated from hydrolysate of human placenta, exhibit potent antihepatitis activity after their oral administration. The increase bilirubin concentration activities cytosolic enzymes serum caused by alpha-naphthylisothiocyanate intoxication...
Non-alcoholic steatohepatitis (NASH) is a severe form of fatty liver disease that defined by the presence inflammation and fibrosis, ultimately leading to cirrhosis hepatocellular carcinoma. Treatment with human placental extract (HPE) reportedly ameliorates hepatic injury. We evaluated effect HPE treatment in mouse model NASH. In methione- choline-deficient (MCD) diet-induced injury model, fibrosis started from regions adjacent sinusoids. administered MCD diet high-salt loading (8% NaCl...
Abstract Proper wound healing is vital for maintenance of corneal integrity and transparency. Corneal epithelial damage one the most frequently observed ocular disorders. Because clinical options are limited, further novel treatments needed to improve outcomes this type disease. In present study, it was found that placental extract-derived dipeptide (JBP485) significantly increased proliferation migration cells (CECs). Moreover, JBP485 accelerated in vivo without inflammation...
Cyclo-trans-4-l-hydroxyprolyl-l-serine (JBP485) was first isolated from Laennec (hydrolysate of human placenta). We thought it valuable to clarify the anti-hepatitis molecular mechanism JBP485 develop a new oral drug.We investigated hepatoprotective effect on immune-mediated, concanavalin A (Con A)-induced liver injury in mice. Mice were administered before and after injection Con (10 mg/kg). Eight hours A, cytosolic enzyme activity (alanine aminotransferase, lactate dehydrogenase) serum, or...
Abstract Dry eye syndrome (DES), a multifactorial disease of the tears and ocular surface, is one most common disorders. Tear film contains mucins essential for maintaining homeostasis wet surface. Since there are limited number clinical options treatment DES, additional novel treatments needed to improve results. In this study, we found that placental extract-derived dipeptide (JBP485) clearly promoted expression secretion gel-forming mucin 5ac (Muc5ac) in rabbit conjunctival epithelium....
The effect of Laennec, a hydrolyte human placenta, on immune-mediated liver injury was investigated in vivo and vitro murine. Vena caudalis administration concanavalin A (Con A) employed to establish an liver-injury model, hepatotoxicity induced by 8 h interaction between Con pre-treated hepatocytes A-stimulated autologous splenic lymphocytes. Laennec used for pre-treatment the two models. decreased biochemical marker activity (alanine aminotransferase, ALT; lactate dehydrogenase, LDH) serum...
Nonlinearity in the overall elimination of hepatocyte growth factor (HGF) was examined rats. After intravenous administration, plasma clearance (CL ) HGF exhibited a dose-dependent biphasic reduction with high- and low-affinity components. If we consider our previous finding that both receptor-mediated endocytosis (RME) uptake mechanism, probably mediated by heparan sulfate proteoglycan (HSPG), liver are major mechanisms, it may be saturation CL at lower higher doses represents RME...