A5100679833- Synthesis and biological activity
- Plant Stress Responses and Tolerance
- Chemical Synthesis and Reactions
- Drug-Induced Hepatotoxicity and Protection
- Cancer therapeutics and mechanisms
- Synthesis and Biological Evaluation
- Chemical Synthesis and Analysis
- Liver Disease Diagnosis and Treatment
- Pharmacological Effects of Natural Compounds
- Natural product bioactivities and synthesis
- Hepatitis B Virus Studies
- Phytochemicals and Antioxidant Activities
- Synthesis and bioactivity of alkaloids
- Plant-derived Lignans Synthesis and Bioactivity
- Metal-Organic Frameworks: Synthesis and Applications
- Liver physiology and pathology
- Nitric Oxide and Endothelin Effects
- Plant responses to elevated CO2
- Covalent Organic Framework Applications
- Trace Elements in Health
- Oxidative Organic Chemistry Reactions
- Histone Deacetylase Inhibitors Research
- Bioactive Compounds and Antitumor Agents
- Synthesis and Characterization of Heterocyclic Compounds
- Heme Oxygenase-1 and Carbon Monoxide
Xinjiang Medical University
2010-2024
Guangzhou Medical University
2019-2024
Shenyang Agricultural University
2020-2024
Zhejiang University
2003-2023
Emory University
2017-2023
Brown University
2020-2023
Ministry of Education of the People's Republic of China
2021
Jiangxi Normal University
2008-2021
Dalian University
2021
Dalian University of Technology
2021
Peptide therapeutics have experienced a rapid resurgence over the past three decades. While few peptide drugs are biologically produced, most manufactured via chemical synthesis. The cycle of prior protection amino group an α-amino acid, activation its carboxyl group, aminolysis with free growing chain, and deprotection N-terminus constitutes principle conventional C → N mandatory use Nα-protecting invokes two additional operations for incorporating each resulting in poor step- atom-economy....
Optimization of isoquinolinone PI3K inhibitors led to the discovery a potent inhibitor PI3K-γ (26 or IPI-549) with >100-fold selectivity over other lipid and protein kinases. IPI-549 demonstrates favorable pharmacokinetic properties robust inhibition mediated neutrophil migration in vivo is currently Phase 1 clinical evaluation subjects advanced solid tumors.
New functionally diverse urea-derived MOF hydrogen-bond-donating heterogeneous catalysts were achieved via postsynthetic modification, which exhibit excellent catalytic activity and very broad substrate scopes for the Friedel–Crafts alkylation reactions.
Abstract Selective bromination of γ‐methylene C(sp 3 )−H bonds aliphatic amides and δ‐methylene nosyl‐protected alkyl amines are developed using NBS as the brominating reagent catalytic amount Cu II /phenanthroline complexes catalyst. Aryl benzylic C−H at other locations remain intact during this directed radical abstraction reaction.
The synthesis of new functionally diverse alkenyl-derived Cr-MIL-101s (MIL=material Institute Lavoisier) was realized by a novel and convenient postsynthetic modification (PSM) protocol means the carbon-carbon bond-forming Mizoroki-Heck reaction. PSM demonstrates broad scope substrates with excellent tolerance functionality under mild reaction conditions. Moreover, metal-organic framework (MOF) that bears both alkenyl thiol side chains prepared tandem method has shown adsorbent ability in...
Misregulation of protein translation plays a critical role in human cancer pathogenesis at many levels. Silvestrol, cyclopenta[b]benzofuran natural product, blocks the initiation step by interfering with assembly eIF4F complex. Silvestrol has complex chemical structure whose functional group requirements have not been systematically investigated. Moreover, silvestrol limited development potential due to poor druglike properties. Herein, we sought develop practical synthesis key intermediates...
Nymphaea candida was used to treat hepatitis in Ugyhur medicine, and nicotiflorin (kaempferol 3-O-β-rutinoside) is the main characteristic component this plant [...].
Hepatitis B is the most common serious liver infection in world. To date, there still no complete cure for chronic hepatitis B. Natural caffeic acid analogues possess prominent antiviral activity, especially anti-hepatitis virus (HBV) and anti-human immunodeficiency effects. Cichoric a derivative from Cichorium intybus. In study, property of cichoric was evaluated by D-galactosamine (D-GalN)-induced normal human HL-7702 hepatocyte injury model, duck (DHBV)-infected fetal hepatocytes...
Multifunctional single‐molecule magnets (SMMs) that combined with chirality and fluorescence properties have attracted considerable attention. In this work, we utilized the chiral Salen‐type Schiff base ligands H2L (H2L = (S,S/R,R)‐N,N′‐bis(3‐methoxysalicylidene)cyclohexane‐1,2‐diamine) to construct three pairs of enantiomeric lanthanide complexes, namely {[Zn(NO3)(L)Ln(DMF)(NO3)2]·[EtOH]}2 (1DyS, Ln Dy, L LS; 1DyR, LR; 2YbS, Yb, 2YbR, LR) [Zn(DMF)(L)Eu(NO3)3]2 (3EuS, 3EuR, LR). Single...
Background Chronic hyperglycemia is known to increase renal injury, particularly during ischemia-reperfusion episodes. The goal of this study was examine whether transient or after increased dysfunction. Methods Male Lewis rats underwent sham operations unilateral nephrectomies followed by contralateral ischemia-reperfusion. Hyperglycemic were given 25% dextrose induce lasting throughout the duration ischemia (PI rats) beginning 2 h initiation reperfusion (PR rats). Additional vehicle...
Cistanche tubulosa is a traditional Chinese herbal medicine widely used for regulating immunity and phenylethanol glycosides (CPhGs) are among the primary components responsible this activity. Previous studies have indicated preventive therapeutic effects of CPhGs on bovine serum albumin (BSA)-induced hepatic fibrosis in rats. The aim study was to evaluate anti-hepatic effect monomers echinacoside acteoside by inhibiting stellate cell (HSC) activation, blocking conduction signaling pathways...
The leaves of Juniperus sabina (Cupressaceae) are used in traditional Uygur medicine for the treatment rheumatism and arthritic pain. This study aimed to investigate analgesic anti‐inflammatory effects total flavonoids from (JSTF) on rodents. activity was investigated using carrageenan, egg albumin, or histamine‐induced rat paw edema as well xylene‐induced ear edema, capillary permeability, cotton pellet granuloma while antinociceptive evaluated mouse writhing, formalin, hot‐plate tests....
A water-removable ynamide coupling reagent for racemization-free construction of amide and ester bonds was reported. No column chromatography purification involved because acidic aqueous work-up removed the byproduct completely.
Exogenous 5-aminolevulinic acid (ALA) positively regulates plants chlorophyll synthesis and protects them against environmental stresses, although the protection mechanism is not fully clear. Here, we explored effects of ALA on in tomato plants, which are sensitive to low temperature. We also examined roles glutathione S-transferase (GSTU43) gene, involved ALA-induced tolerance oxidation stress regulation under temperature.Exogenous alleviated temperature caused obstacle uroporphyrinogen III...