A5064950342- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Liver Disease Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Cardiac Imaging and Diagnostics
- Advanced Neuroimaging Techniques and Applications
- Photoacoustic and Ultrasonic Imaging
- Ultrasound and Hyperthermia Applications
- Atomic and Subatomic Physics Research
- Prostate Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Cardiovascular Function and Risk Factors
- Radiomics and Machine Learning in Medical Imaging
- Ultrasound Imaging and Elastography
- Hepatocellular Carcinoma Treatment and Prognosis
- Cardiovascular Disease and Adiposity
- Cardiomyopathy and Myosin Studies
- Medical Image Segmentation Techniques
- Cardiovascular Effects of Exercise
- Pregnancy and preeclampsia studies
- NMR spectroscopy and applications
- Soft Robotics and Applications
- Body Composition Measurement Techniques
- Advanced NMR Techniques and Applications
- Nanoparticle-Based Drug Delivery
University of California, Los Angeles
2016-2025
Samueli Institute
2024
California NanoSystems Institute
2021
Los Angeles City College
2019-2020
Ronald Reagan UCLA Medical Center
2016-2018
University of California System
2018
Cathay General Hospital
2016
Fu Jen Catholic University
2016
Peking University
2014
Peking University Cancer Hospital
2014
To evaluate convex optimized diffusion encoding (CODE) gradient waveforms for minimum echo time and bulk motion-compensated diffusion-weighted imaging (DWI).Diffusion-encoding were designed a range of b-values spatial resolutions with without motion compensation using the CODE framework. CODE, first moment (M1 ) nulled CODE-M1 , second (M2 M2 used to acquire neuro, liver, cardiac ADC maps in healthy subjects (n=10) that compared respectively monopolar (MONO), BIPOLAR = 0), (MOCO, M1 + 0)...
Magnetic resonance imaging (MRI) is an essential modality for clinical diagnosis, and MRI-guided high-intensity focused ultrasound (MRgHIFU) a powerful technology targeted therapy. Clinical applications of MRgHIFU primarily utilize hyperthermia ablation to treat cancerous tissue, but drug delivery thermal damage undesirable. A biofriendly MRgHIFU-responsive mesoporous silica nanoparticle (MSN) platform that stimulated within physiological safe temperature range has been developed, reducing...
Abstract Fast imaging trajectories are used in MRI to speed up the acquisition process, but imperfections gradient system create artifacts reconstructed images. Artifacts result from deviation between k ‐space achieved on scanner and their original prescription. Measuring or approximating actual with predetermined timing delays reduces artifacts, generally based a specific trajectory scan orientation. A single linear time‐invariant characterization of provides method predict scanned...
Purpose To determine the diagnostic yield of in-bore 3-T magnetic resonance (MR) imaging-guided prostate biopsy and stratify performance according to Prostate Imaging Reporting Data System (PI-RADS) versions 1 2. Materials Methods This study was HIPAA compliant institution review board approved. In-bore MR-guided performed in 134 targets 106 men who (a) had not previously undergone biopsy, (b) prior negative findings with increased prostate-specific antigen (PSA) level, or (c) a history...
Background Microstructural MRI has the potential to improve diagnosis and characterization of prostate cancer (PCa), but validation with histopathology is lacking. Purpose To validate ex vivo diffusion-relaxation correlation spectrum imaging (DR-CSI) in microstructural tissue compartments specimens from men PCa by using registered whole-mount digital (WMHP) as reference standard. Materials Methods Men who underwent 3-T robotic-assisted radical prostatectomy between June 2018 January 2019...
Noninvasive visualization of the coronary arteries in vivo is one most important goals cardiovascular imaging. Compared to other paradigms for MR angiography, a free-breathing three-dimensional whole-heart iso-resolution approach simplifies prescription effort, requires less patient cooperation, reduces overall exam time, and supports retrospective reformats at arbitrary planes. However, this long continuous acquisition must account respiratory cardiac motion throughout scan. In work, new...
Purpose To implement a nonrigid autofocus motion correction technique to improve respiratory of free‐breathing whole‐heart coronary magnetic resonance angiography acquisitions using an image‐navigated 3D cones sequence. Methods 2D image navigators acquired every heartbeat are used measure superior‐inferior, anterior‐posterior, and right‐left translation the heart during scan readout trajectory. Various tidal patterns modeled by independently scaling three measured displacement trajectories....
The diagnostic gold standard for nonalcoholic fatty liver disease is an invasive biopsy. Noninvasive Cartesian MRI fat quantification remains limited to a breath-hold (BH). In this work, novel free-breathing 3D stack-of-radial (FB radial) technique developed and evaluated in preliminary study.Phantoms healthy subjects (n = 11) were imaged at 3 Tesla. proton-density fraction (PDFF) determined using FB radial (with without scan acceleration) was compared BH single-voxel MR spectroscopy (SVS)...
Background: Duchenne Muscular Dystrophy (DMD) is a prevalent fatal genetic disorder, and heart failure the leading cause of mortality. Peak left ventricular (LV) circumferential strain (Ecc), twist, circumferential-longitudinal shear angle (θCL) are promising biomarkers for improved early diagnosis incipient failure. Our goals were as follows: 1) to characterize spectrum functional rotational LV in boys with DMD compared healthy age-matched controls; 2) identify cardiomyopathy absence...
Increased subcutaneous and visceral adipose tissue (SAT/VAT) volume is associated with risk for cardiometabolic diseases. This work aimed to develop evaluate automated abdominal SAT/VAT segmentation on longitudinal MRI in adults overweight/obesity using attention-based competitive dense (ACD) 3D U-Net nnU-Net full field-of-view volumetric multi-contrast inputs.
Purpose To improve the spatial/temporal resolution of whole‐heart coronary MR angiography by developing a variable‐density (VD) 3D cones acquisition suitable for image reconstruction with parallel imaging and compressed sensing techniques. Methods A VD trajectory design incorporates both radial spiral undersampling techniques to achieve higher resolution. This is used generate 0.8 mm/66 ms isotropic resolution, using similar number readouts as our previous fully sampled (1.2 mm/100 ms)....
Background Patient‐specific 3D‐printed molds and ex vivo MRI of the resected prostate have been two important strategies to align with whole‐mount histopathology (WMHP) for cancer (PCa) research, but combination these has not systematically evaluated. Purpose To develop evaluate a system that combines patient‐specific (ExV) spatially in (InV), ExV, WMHP PCa patients. Study Type Prospective cohort study. Population Seventeen patients who underwent 3T robotic‐assisted laparoscopic radical...
Background Multiecho gradient‐echo Cartesian MRI characterizes placental oxygenation by quantifying . Previous research was performed at 1.5T using breath‐held 2D imaging during later gestational age (GA). Purpose To evaluate the accuracy and repeatability of a free‐breathing (FB) 3D multiecho stack‐of‐radial technique (radial) for mapping 3T report early GA. Study Type Prospective. Population Thirty subjects with normal pregnancies three ischemic disease (IPD) were scanned twice: between...
More than 100 attendees from Australia, Austria, Belgium, Canada, China, Germany, Hong Kong, Indonesia, Japan, Malaysia, the Netherlands, Philippines, Republic of Korea, Singapore, Sweden, Switzerland, United Kingdom, and States convened in Singapore for 2019 ISMRM‐sponsored workshop on MRI Obesity Metabolic Disorders. The scientific program brought together a multidisciplinary group researchers, trainees, clinicians included sessions diabetes insulin resistance; an update recent advances...
Purpose To develop an accurate free‐breathing 3D liver mapping approach and to evaluate it in vivo. Methods A multi‐echo stack‐of‐radial sequence was applied 5 normal subjects 6 patients at 3 Tesla. Respiratory motion compensation implemented using the inherent self‐gating signal. breath‐hold Cartesian acquisition reference standard. Proton density fat fraction were measured compared between radial methods Bland‐Altman plots. The subject results fitted a linear mixed model ( P < .05...
Purpose Increased utilization of magnetic resonance imaging (MRI) in radiotherapy has caused a growing need for phantoms that provide tissue‐like contrast both computed tomography (CT) and MRI images. Such can be used to compare MRI‐based processes with CT‐based clinical standards. Here, we develop demonstrate the utility three‐dimensional (3D)‐printed anthropomorphic pelvis phantom containing materials capable T 1 , 2 electron density matching clinically relevant set soft tissues bone....
Background Stack‐of‐radial multiecho gradient‐echo MRI is promising for free‐breathing liver quantification and may benefit children. Purpose To validate stack‐of‐radial with self‐gating motion compensation in phantoms, to evaluate it Study Type Prospective. Phantoms Four vials different driven by a stage. Subjects Sixteen pediatric patients suspected nonalcoholic fatty disease or steatohepatitis (five females, 13 ± 4 years, body mass index 29.2 8.6 kg/m 2 ). Field Strength/Sequences...
To develop and evaluate a rapid three-dimensional (3D) quantitative T2 mapping method for prostate cancer imaging using dual echo steady state (DESS) MRI at 3T.In simulations, DESS-T2 in the presence of T1 B1+ variations was evaluated. In phantom healthy volunteers (n = 4), 3D compared with two-dimensional turbo spin (TSE) approach. pilot patient study 29), normal anatomical zones suspected cancerous lesions evaluated.The simulated bias < 2% (5%) typically observed ( B1+) variations....
To improve image quality, mitigate quantification biases and variations for free-breathing liver proton density fat fraction (PDFF)