A5007234213- Congenital Heart Disease Studies
- Cardiomyopathy and Myosin Studies
- Cardiac Valve Diseases and Treatments
- Advanced MRI Techniques and Applications
- Cardiovascular Effects of Exercise
- Cardiovascular Function and Risk Factors
- Muscle Physiology and Disorders
- Cardiac Arrhythmias and Treatments
- Pulmonary Hypertension Research and Treatments
- Cardiac Imaging and Diagnostics
- Coronary Artery Anomalies
- Streptococcal Infections and Treatments
- Infective Endocarditis Diagnosis and Management
- Congenital Diaphragmatic Hernia Studies
- Lysosomal Storage Disorders Research
- Trypanosoma species research and implications
- Cardiac Structural Anomalies and Repair
- Cardiovascular Disease and Adiposity
- Mechanical Circulatory Support Devices
- Celiac Disease Research and Management
- Muscle activation and electromyography studies
- Infectious Diseases and Tuberculosis
- Prenatal Screening and Diagnostics
- Transcranial Magnetic Stimulation Studies
- Otolaryngology and Infectious Diseases
University of California, Los Angeles
2012-2025
Children's Hospital of Orange County
2011-2025
Ronald Reagan UCLA Medical Center
2008-2023
University of California, Irvine
2011-2022
Los Angeles Medical Center
2022
Boston Children's Hospital
2012-2014
Harvard University
2014
Mattel Children's Hospital
2007-2010
UCLA Medical Center
2008
Background: Duchenne Muscular Dystrophy (DMD) is a prevalent fatal genetic disorder, and heart failure the leading cause of mortality. Peak left ventricular (LV) circumferential strain (Ecc), twist, circumferential-longitudinal shear angle (θCL) are promising biomarkers for improved early diagnosis incipient failure. Our goals were as follows: 1) to characterize spectrum functional rotational LV in boys with DMD compared healthy age-matched controls; 2) identify cardiomyopathy absence...
Purpose To develop and validate a technique for myocardial T1 mapping in patients with implantable cardioverter defibrillators (ICDs). Methods A MOLLI-based pulse sequence, named Wideband-FLASH-MOLLI, was developed by incorporating fast low angle shot (FLASH) readout wideband inversion pulse. The performance of Wideband-FLASH-MOLLI evaluated using phantom studies validated eight healthy volunteers ten ICDs at 1.5 Tesla. Comparisons were made between FLASH-MOLLI, bSSFP-MOLLI sequences....
The prevalence of aortic root dilatation (ARD) in mucopolysaccharidosis (MPS) is not well documented. We investigated measurements 34 MPS patients at the Children's Hospital Orange County (CHOC). diagnosis, treatment status, age, gender, height, weight and parameters (aortic valve annulus (AVA), sinuses Valsalva (SoV), sinotubular junction (STJ)) were extracted by retrospective chart review echocardiographic measurements. Descriptive statistics, ANOVA, paired post-hoc t-tests used to...
We report a case of 15-year-old female presenting with serious multisystemic inflammatory illness during surge SARS-CoV-2 (COVID-19) cases in our county. The initial clinical findings sore throat and neck stiffness, followed by signs sepsis, raised suspicion Lemierre syndrome early her hospital course. However, the presence severe respiratory distress, multifocal pneumonia pleural effusion on chest radiograph, acute kidney injury, discovery coronary artery ectasia, pointed to new entity...
Abstract: We report a case of 16‐yr‐old male with Danon disease caused by novel mutation in the LAMP‐2 gene. Mutations gene result absence on immunohistochemical staining muscle tissue, thus defining disease, rare X‐linked myopathy. It is characterized clinically HCM or left ventricular hypertrophy, WPW pattern ECG, variable degrees muscular weakness (skeletal myopathy), mental retardation, and retinal changes. The patient presented severe skeletal respiratory failure. He also had history...
Diagnosing prosthetic valve infective endocarditis in children is challenging. Transthoracic and transesophageal echocardiography can yield false-negative results. Data are lacking paediatric multimodality imaging endocarditis. We present two with repaired CHD where initial echocardiogram was non-diagnostic, while CT angiogram 18F-fluorodeoxyglucose positron emission tomography combination angiography, respectively, confirmed the diagnosis of affecting clinical management.
Cardiovascular disease is the leading cause of death in patients with Duchenne muscular dystrophy (DMD)—a fatal X-linked genetic disorder. Late gadolinium enhancement (LGE) imaging current gold standard for detecting myocardial tissue remodeling, but it often a late finding. Current research aims to investigate cardiovascular magnetic resonance (CMR) biomarkers, including native (pre-contrast) T1 and extracellular volume (ECV) evaluate early on-set microstructural remodeling grade severity....
Comprehensive assessment of pediatric congenital heart disease (CHD) at any field strength mandates evaluation both vascular and dynamic cardiac anatomy for which diagnostic quality contrast-enhanced magnetic resonance angiography (CEMRA) cine are crucial. To determine whether high-resolution (HR) CEMRA steady-state free precession (SSFP) can be performed reliably 3.0 T in children with CHD to compare the image similar techniques 1.5 T. Twenty-eight patients a median age 5 months average...
Abstract Objective To determine the attitudes of pediatric residents and nurses towards fetal/neonatal management hypoplastic left heart syndrome (HLHS), their basis. Methods Pediatric from three cardiac centers completed a survey with hypothetical scenarios in which own fetuses or newborns had HLHS. While Institution A performs many HLHS surgeries, C very few. Results total 43% 50% would terminate an affected pregnancy. More experience (4 to 7 years, p = 0.04; >7 0.05) employment at...
Background Clinical management of boys with Duchenne muscular dystrophy (DMD) relies on in‐depth understanding cardiac involvement, but right ventricular (RV) structural and functional remodeling remains understudied. Purpose To evaluate several analysis methods identify the most reliable one to measure RV pre‐ postcontrast T1 (RV‐T1) characterize myocardial in DMD. Study Type Prospective. Population Boys DMD ( N = 27) age‐/sex‐matched healthy controls 17) from two sites. Field...
Motivation: Duchenne muscular dystrophy (DMD) leads to pediatric cardiomyopathy. Pre-contrast T1 in DMD identifies myocardial remodeling, but it remains unclear if T1-Mapping biomarkers can detect longitudinal changes DMD. Goal(s): The objective was characterize progressive pre-contrast at 3T. Approach: Boys with and healthy controls underwent a 3T CMR exam that included standard functional mapping sequences. were examined two points (18 months apart). Results: capable of detecting boys 18...
Background: In boys with Duchenne muscular dystrophy (DMD), cardiomyopathy has become the primary cause of death. Although both positive late gadolinium enhancement (LGE) and reduced left ventricular ejection fraction (LVEF) are findings in a DMD cohort, LV end-systolic circumferential strain at middle wall (Ecc) serves as biomarker for detecting early impairment cardiac function associated DMD. However, Ecc derived from cine Displacement Encoding Stimulated Echoes (DENSE) not been...
Imaging of complex congenital heart diseases (CHDs) in children is challenging. This article reviews the complementary role high temporal and spatial resolution magnetic resonance (MR) angiographic imaging techniques evaluation a patient with cardiovascular disease related postsurgical complications. A 4-year-old female CHD multiple previous palliative surgical procedures underwent MR angiography to evaluate cause refractory hypoxia. High-resolution demonstrated anatomy also assisted...
Left ventricular (LV) peak mid-wall circumferential strain (E cc ) and twist are early biomarkers for evaluating the subtle highly variable onset progression of cardiomyopathy in pediatric subjects with Duchenne muscular dystrophy (DMD). Cine Displacement Encoding Stimulated Echoes (DENSE) has proven sensitive to changes E twist, but not been reported a DMD cohort. We show that free-breathing DENSE CMR at 3T provides reproducible middle-ventricular , radial rr ), measurements healthy boys...
Author(s): Nguyen, Kim-Lien; Khan, Sarah; Moriarty, John; Mohajer, Kiyarash; Renella, Pierangelo; Satou, Gary; Ayad, Ihab; Patel, Swati; Boechat, Ines; Finn, J