A5086145341- Pregnancy and preeclampsia studies
- Prenatal Screening and Diagnostics
- Maternal and Perinatal Health Interventions
- Neonatal Respiratory Health Research
- Fetal and Pediatric Neurological Disorders
- Assisted Reproductive Technology and Twin Pregnancy
- COVID-19 Impact on Reproduction
- Maternal and fetal healthcare
- Neonatal and fetal brain pathology
- Non-Invasive Vital Sign Monitoring
- Nerve Injury and Rehabilitation
- Trauma and Emergency Care Studies
- Preterm Birth and Chorioamnionitis
- Urological Disorders and Treatments
- Global Maternal and Child Health
- Cardiovascular Issues in Pregnancy
- Maternal Mental Health During Pregnancy and Postpartum
- Blood groups and transfusion
- Hemoglobinopathies and Related Disorders
- Pediatric Urology and Nephrology Studies
- Trauma Management and Diagnosis
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Urinary Tract Infections Management
- Healthcare Policy and Management
University of California, Davis
2016-2025
UC Davis Health System
2023-2024
Community Link
2023
Shriners Hospitals for Children - Northern California
2023
National Center for Advancing Translational Sciences
2023
University of California Davis Medical Center
1997-2023
Society for Maternal-Fetal Medicine
2013-2020
John Wiley & Sons (United Kingdom)
2020
Hudson Institute
2020
Natera (United States)
2018-2019
We analyzed maternal plasma cell-free DNA samples from twin pregnancies in a prospective blinded study to validate single-nucleotide polymorphism (SNP)-based non-invasive prenatal test (NIPT) for zygosity, fetal sex, and aneuploidy. Zygosity was evaluated by looking either one or two genome complements, sex evaluating Y-chromosome loci, aneuploidy assessed through SNP ratios. correctly predicted 100% of cases (93/93; 95% confidence interval (CI) 96.1%–100%). Individual both twins also called...
Abstract Objectives The performance of noninvasive prenatal screening (NIPS) for fetal aneuploidy in twin pregnancies is dependent on the amount placentally derived cell‐free DNA, “fetal fraction (FF),” present maternal plasma. We report FF values monozygotic (MZ) and dizygotic (DZ) pregnancies. Methods reviewed at 10 to 20 completed weeks gestational age based single‐nucleotide polymorphism (SNP)‐based NIPS where zygosity was routinely established cohort included 121 446 (96.3%) singleton,...
Abstract Objective To investigate the association of maternal race/ethnicity with risk factors for brachial plexus birth injury (BPBI) and quantify proportion excess BPBI due to these factors. Study design This retrospective cohort study all livebirths occurring in California-licensed hospitals from 1996–2012 included 6,278,562 maternal-livebirth infant pairs 7762 diagnoses. Multiple logistic regression causal mediation analyses were used evaluate relationship Results Black Hispanic...
Abstract Cardiotocography (CTG) has a high false positive rate for the detection of babies at risk birth asphyxia. Transabdominal Fetal Pulse Oximetry (TFO) potential to supplement CTG by enabling non-invasive measurement fetal arterial blood oxygen saturation (fSpO 2 ). Previous attempts TFO were limited intermittent measurements using highly specialized and precise instruments. We present system, utilizing multiple commodity silicon photo-detectors acquire mixed maternal-fetal PPG signals,...
(Abstracted from Am J Obstet Gynecol 2016;214:527.e1–527.e6) There has been an incessant increase in maternal mortality during the past 20 years United States. Maternal morbidity is also on upward trend.
Current intrapartum fetal monitoring technology is unable to provide physicians with an objective metric of well-being, leading degraded patient outcomes and increased litigation costs. Fetal oxygen saturation (SpO2) a more suitable measure distress, but the inaccessibility fetus prior birth makes this impossible capture through current means. In paper, we present fully non-invasive, transabdominal oximetry (TFO) system that provides in utero measures SpO2.TFO performed by placing...
Twins account for approximately 1 in 30 live births the United States. However, there are limited clinical experience studies published noninvasive prenatal testing (NIPT) detecting aneuploidies twins. This study reports performance of an SNP-based NIPT largest cohort with known outcomes high-risk aneuploidy results.This is a retrospective analysis 18,984 results from commercial single-nucleotide polymorphism (SNP)-based tests performed twins between October 2, 2017 and December 31, 2019....
OBJECTIVES/GOALS: To evaluate the incidence of brachial plexus birth injury (BPBI) and its associations with maternal demographic factors. Additionally, we sought to determine whether longitudinal changes in BPBI differed by demographics. METHODS/STUDY POPULATION: We conducted a retrospective cohort study over 8 million maternal-infant pairs using California’s Office Statewide Health Planning Development Linked Birth Files from 1991-2012. Descriptive statistics were used prevalence factors...